公开(公告)号：US20240018153A1

公开(公告)日：2024-01-18

申请号：US18253730

申请日：2021-11-18

申请人： 2692372 ONTARIO, INC. ,  DUNAD THERAPEUTICS LTD.

发明人： Patrick T. GUNNING ,  Jeff OMEARA ,  Siawash AHMAR ,  Graham L. SIMPSON ,  Peter HUNT ,  David Alexander ROSA ,  Ji Sung PARK

IPC分类号： C07D487/04 ,  C07D403/04 ,  C07D239/48 ,  C07D401/12 ,  C07D213/76 ,  C07D213/74 ,  C07C317/32 ,  C07D405/12 ,  C07K1/10

CPC分类号： C07D487/04 ,  C07D403/04 ,  C07D239/48 ,  C07D401/12 ,  C07D213/76 ,  C07D213/74 ,  C07C317/32 ,  C07D405/12 ,  C07K1/10

摘要： Provided herein are benzenesulfonamide compounds, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

公开(公告)号：US20230055961A1

公开(公告)日：2023-02-23

申请号：US17748431

申请日：2022-05-19

申请人： Dunad Therapeutics Ltd. ,  2692372 ONTARIO INC.

发明人： Dziyana KRASKOUSKAYA ,  Siawash AHMAR ,  Patrick T. GUNNING ,  Jeff OMEARA ,  David Alexander ROSA ,  Ji Sung PARK ,  Graham L. SIMPSON ,  Ayah ABDELDAYEM

IPC分类号： C07D487/04

摘要： Provided herein are pentafluorobenzenesulfonamide compounds, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

公开(公告)号：US20240092756A1

公开(公告)日：2024-03-21

申请号：US18253712

申请日：2021-11-18

申请人： 2692372 ONTARIO, INC. ,  DUNAD THERAPEUTICS LTD.

发明人： Patrick T. GUNNING ,  Jeff OMEARA ,  Siawash AHMAR ,  Graham L. SIMPSON ,  Peter HUNT ,  David Alexander ROSA ,  Ji Sung PARK

IPC分类号： C07D401/12 ,  C07D215/12 ,  C07D215/42 ,  C07D401/04 ,  C07D471/14

CPC分类号： C07D401/12 ,  C07D215/12 ,  C07D215/42 ,  C07D401/04 ,  C07D471/14 ,  C07B2200/09

摘要： Provided herein are compounds binding to KRAS protein or a mutant thereof, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

公开(公告)号：US20220281812A1

公开(公告)日：2022-09-08

申请号：US17627307

申请日：2020-07-17

申请人： 2692372 Ontario, Inc. ,  Dunad Therapeutics LTD.

发明人： Patrick T. GUNNING ,  Ji Sung PARK ,  Siawash AHMAR ,  Aaron D. CABRAL ,  Gary K.C. TIN ,  Sana RASHEED ,  Ayah ABDELDAYEM ,  David ARMSTRONG ,  Geordon A. FRERE ,  Erica J. QUILATES ,  David Alexander ROSA ,  Olga GOZHINA ,  Jeffrey Alan OMEARA ,  Graham SIMPSON ,  Vittoria ZOPPI

IPC分类号： C07C311/29 ,  C07D487/04 ,  C07D205/04 ,  C07D239/48 ,  C07D305/06 ,  C07D213/30 ,  C07D295/096 ,  C07C311/39 ,  C07D213/74 ,  A61K9/48 ,  A61K9/00 ,  A61K9/08 ,  C07K1/107

摘要： Provided herein are benzenesulfonamide derivatives having Formula (III), pharmaceutical compositions comprising said compounds, and method for using said compounds for disrupting proteins/polypeptides, protein/polypeptide function, and for the treatment of diseases through the disruption of proteins or polypeptides involved in the etiology of the disease. Said compounds comprise fluorinated benzene sulfonamide structures.