公开(公告)号：US20210025898A1

公开(公告)日：2021-01-28

申请号：US16062734

申请日：2016-12-15

Applicant: Dyax Corp.

Inventor： Jiang Wu ,  Guodong Zhang ,  Daniel J. Sexton ,  Ryan Faucette ,  Gul M. Mustafa ,  Mark Szewc

IPC: G01N33/68 ,  G01N30/88 ,  G01N30/72

Abstract: Methods for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK in a sample are provided herein. Such methods may comprise treating a biological sample with a protease to generate a plurality of digested peptides, and measuring one or more signature peptides, which are indicative of cleaved HMWK and/or full-length HMWK.