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公开(公告)号：US20210322972A1
公开(公告)日：2021-10-21
申请号：US17102509
申请日：2020-11-24
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Ryan Faucette
IPC: B01L3/00 , A61B5/15 , A61B5/154 , C07K16/40 , G01N33/564 , G01N33/573 , G01N33/96
Abstract: Disclosed herein are evacuated blood collection tubes comprising protease inhibitor cocktails in liquid form and uses thereof for assessing features associated with the contact system in a subject, including the endogenous level of contact system activation, the endogenous level of a drug that targets a component of contact system during treatment, and/or the immunogenicity of such a drug.
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公开(公告)号：US20210087293A1
公开(公告)日：2021-03-25
申请号：US17010354
申请日：2020-09-02
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Burt Adelman , Yung Chyung , Christopher TenHoor , Jon A. Kenniston , Ryan Faucette , Ryan Iarrobino , Joseph Biedenkapp
IPC: C07K16/40
Abstract: Provided herein are plasma kallikrein binding proteins such as antibodies binding to active plasma kallikrein and methods of using such proteins in treating hereditary angioedema.
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公开(公告)号：US20190241961A1
公开(公告)日：2019-08-08
申请号：US16333177
申请日：2017-09-15
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Malini Viswanathan , Ryan Faucette , Tripti Gaur
IPC: C12Q1/6883 , C12Q1/686 , C12Q1/6813 , C12Q1/6851
CPC classification number: C12Q1/6883 , C12Q1/6813 , C12Q1/6851 , C12Q1/686 , C12Q1/6876 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/502 , G01N2800/224
Abstract: Provided herein are methods and kits for analyzing a biological sample obtained from a subject having, suspected of having, or being at risk for a disease associated with the contact activation system.
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4.发明申请公开(公告)号：US20160252527A1
公开(公告)日：2016-09-01
申请号：US15030811
申请日：2014-10-17
Applicant: DYAX CORP.
Inventor： Daniel J. Sexton , Ryan Faucette , Jon A. Kenniston , Gregory P. Conley , Andrew Nixon , Christopher TenHoor , Burt Adelman
CPC classification number: G01N33/6893 , A61K2039/505 , C07K16/36 , C07K16/40 , C07K2317/76 , C12Q1/37 , C12Q1/56 , C12Y304/21034 , C12Y304/21038 , G01N2333/4713 , G01N2333/96455 , G01N2333/96458 , G01N2500/02 , G01N2500/20 , G01N2800/224 , G01N2800/50 , G01N2800/52
Abstract: Methods and assays for determining the activation level of the plasma kallikrein (pKal) system and the uses thereof for assessing the activity of pKal modulators on the pKal system.
Abstract translation: 用于确定血浆激肽释放酶（pKal）系统的激活水平的方法和测定及其用于评估pKal系统上pKal调节剂活性的用途。
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公开(公告)号：US20210270842A1
公开(公告)日：2021-09-02
申请号：US17141690
申请日：2021-01-05
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Ryan Faucette , Janja Cosic
IPC: G01N33/68 , G01N33/86 , C07K16/36 , G01N33/543
Abstract: The present disclosure provides immunoassay methods of detecting a cleaved high molecular weight kininogen (HMWK) with high sensitivity and specificity and isolated antibodies that specifically bind cleaved HMWK.
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Patent Agency Ranking
公开(公告)号：US20210025898A1
公开(公告)日：2021-01-28
申请号：US16062734
申请日：2016-12-15
Applicant: Dyax Corp.
Inventor： Jiang Wu , Guodong Zhang , Daniel J. Sexton , Ryan Faucette , Gul M. Mustafa , Mark Szewc
Abstract: Methods for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK in a sample are provided herein. Such methods may comprise treating a biological sample with a protease to generate a plurality of digested peptides, and measuring one or more signature peptides, which are indicative of cleaved HMWK and/or full-length HMWK.
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公开(公告)号：US20180306807A1
公开(公告)日：2018-10-25
申请号：US15769237
申请日：2016-10-19
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Ryan Faucette , Janja Cosic
IPC: G01N33/68 , G01N33/86 , G01N33/543 , C07K16/36
CPC classification number: G01N33/6893 , C07K16/36 , G01N33/54306 , G01N33/86 , G01N2333/745 , G01N2800/50
Abstract: The present disclosure provides immunoassay methods of detecting a cleaved high molecular weight kininogen (HMWK) with high sensitivity and specificity and isolated antibodies that specifically bind cleaved HMWK
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8.发明申请PLASMA KALLIKREIN BINDING PROTEINS AND USES THEREOF IN TREATING HEREDITARY ANGIOEDEMA 审中-公开PLASMA KALLIKREIN结合蛋白及其在治疗放疗中的应用公开(公告)号：US20170002094A1
公开(公告)日：2017-01-05
申请号：US15113297
申请日：2015-01-21
Applicant: DYAX CORP.
Inventor： Daniel J. Sexton , Burt Adelman , Yung Chyung , Christopher TenHoor , Jon A. Kenniston , Ryan Faucette , Rayan larrobino , Joe Biedenkapp
IPC: C07K16/40
CPC classification number: C07K16/40 , A61K2039/505 , A61K2039/545 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: Provided herein are plasma kallikrein binding proteins such as antibodies binding to active plasma kallikrein and methods of using such proteins in treating hereditary angioedema.
Abstract translation: 本文提供血浆激肽释放酶结合蛋白，例如结合活性血浆激肽释放酶的抗体以及使用这些蛋白质治疗遗传性血管性水肿的方法。
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公开(公告)号：US20210285962A1
公开(公告)日：2021-09-16
申请号：US16333155
申请日：2017-09-15
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Malini Viswanathan , Ryan Faucette , Tripti Gaur
Abstract: Provided herein are methods and kits for analyzing a biological sample obtained from a subject having, suspected of having, or being at risk for a disease associated with the contact activation system.
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公开(公告)号：US10914747B2
公开(公告)日：2021-02-09
申请号：US15769237
申请日：2016-10-19
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Ryan Faucette , Janja Cosic
IPC: G01N33/86 , C07K16/36 , G01N33/68 , G01N33/543
Abstract: The present disclosure provides immunoassay methods of detecting a cleaved high molecular weight kininogen (HMWK) with high sensitivity and specificity and isolated antibodies that specifically bind cleaved HMWK.
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