公开(公告)号：US20180118851A1

公开(公告)日：2018-05-03

申请号：US15541066

申请日：2015-12-31

Applicant: Dyax Corp.

Inventor： Stephen R. Comeau ,  Andrew Nixon ,  Niksa Kastrapeli ,  Jon A. Kenniston ,  Gregory P. Conley ,  Shauna Mason ,  Allison P. Lindberg ,  Kristopher Kopacz ,  Burt Adelman

IPC: C07K16/40 ,  C07K16/36 ,  C12N9/64 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K39/395 ,  A61P7/02 ,  C07K16/36 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/94 ,  C12N9/64

Abstract: Described herein are bispecific antibodies that bind to plasma kallikrein (pKal) and Factor XII and methods of producing and using such bi-specific antibodies for treating diseases or disorders associated with the contact system, e.g., hereditary angioedema or thrombosis. One aspect of the present disclosure is a bispecific antibody, comprising: a first polypeptide that comprises a light chain of a first antibody, the light chain comprising a light chain variable region (VL) and a light chain constant region (CL) (e.g., a kappa light chain or a lambda light chain); and a second polypeptide that comprises a heavy chain of the first antibody, the heavy chain comprising a heavy chain variable region (VH) and a heavy chain constant region (CH).