公开(公告)号：US20190240323A1

公开(公告)日：2019-08-08

申请号：US15958295

申请日：2018-04-20

Applicant: Dynavax Technologies Corporation

Inventor： Gary S. OTT ,  Robert J. MILLEY ,  Robert L. COFFMAN ,  Radwan KIWAN ,  Holger KANZLER

IPC: A61K39/39 ,  A61K47/61 ,  C07H21/00 ,  A61K47/60 ,  A61K39/12 ,  C07H21/04 ,  A61K31/7125 ,  A61K39/07

CPC classification number: A61K39/39 ,  A61K31/7125 ,  A61K39/07 ,  A61K39/12 ,  A61K47/60 ,  A61K47/61 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55561 ,  A61K2039/572 ,  A61K2039/575 ,  C07H21/00 ,  C07H21/04 ,  C12N2730/10134

Abstract: The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.

公开(公告)号：US20190151462A1

公开(公告)日：2019-05-23

申请号：US16190010

申请日：2018-11-13

Applicant: Dynavax Technologies Corporation

Inventor： Robert L. COFFMAN ,  Stewart D. CHIPMAN ,  Radwan KIWAN ,  Samuel ZALIPSKY ,  Gary S. OTT

IPC: A61K47/65 ,  A61K47/68 ,  A61P35/00 ,  A61K47/60 ,  A61K31/4745

Abstract: The present disclosure relates to cleavable conjugates (for example, particle-based or antibody-based conjugates) of TLR7/8 agonists (for example, 1H-imidazo[4,5-c]quinoline derivatives) containing a conjugation linker, a cleavable linker, and a self-eliminating linker. The present disclosure also related to methods for preparation of the cleavable conjugates, uses thereof for stimulating an effective immune response, and uses thereof for the treatment of cancer.

公开(公告)号：US20180360954A1

公开(公告)日：2018-12-20

申请号：US15958292

申请日：2018-04-20

Applicant: Dynavax Technologies Corporation

Inventor： Gary S. OTT ,  Robert J. MILLEY ,  Robert L. COFFMAN ,  Radwan KIWAN ,  Holger KANZLER

IPC: A61K39/39 ,  A61K31/7125

CPC classification number: A61K39/39 ,  A61K31/7125 ,  A61K39/07 ,  A61K39/12 ,  A61K47/60 ,  A61K47/61 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55561 ,  A61K2039/572 ,  A61K2039/575 ,  C07H21/00 ,  C07H21/04 ,  C12N2730/10134

Abstract: The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.