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公开(公告)号：US20160324131A1
公开(公告)日：2016-11-10
申请号：US15218202
申请日：2016-07-25
发明人： Kazuma Tomizuka , Isao Ishida , Nils Lonberg , Edward L. Halk
IPC分类号： A01K67/027 , C12N15/85 , C07K16/18 , C07K16/00 , C07K16/28 , C07K16/24 , C12Q1/68 , C12P21/00
CPC分类号： A01K67/0278 , A01K67/02 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K39/00 , A61K2039/505 , C07K14/70535 , C07K16/00 , C07K16/18 , C07K16/243 , C07K16/2812 , C07K16/2818 , C07K16/2863 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/92 , C12N5/0635 , C12N5/163 , C12N15/8509 , C12N2015/8518 , C12P21/005 , C12Q1/6881 , C12Q2600/158
摘要： The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
摘要翻译： 本发明提供能够产生人序列抗体的新型转基因非人哺乳动物，以及生产和使用这些抗体的方法。
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公开(公告)号：US20160222114A1
公开(公告)日：2016-08-04
申请号：US15098627
申请日：2016-04-14
发明人： Jennifer Marie MATARAZA , Andrea Van Elsas , Alan J. Korman , Edward L. Halk , Kent B. Thudium , Mark J. Selby , Timothy W. Sproul , Heidi N. Leblanc
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2818 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to binding compounds specific for BTLA and uses thereof. More specifically, the invention relates to fully human antibodies that recognize human BTLA and modulate its activity in cancer, inflammatory, and autoimmune disorders.
摘要翻译： 本发明涉及对BTLA特异性的结合化合物及其用途。 更具体地，本发明涉及识别人BTLA并调节其在癌症，炎性和自身免疫性疾病中的活性的完全人抗体。
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公开(公告)号：US20190119384A1
公开(公告)日：2019-04-25
申请号：US16232463
申请日：2018-12-26
IPC分类号： C07K16/28 , A01K67/027 , C12N15/85 , A61K39/395
摘要： The presently subject matter provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
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公开(公告)号：US10155813B2
公开(公告)日：2018-12-18
申请号：US15098627
申请日：2016-04-14
发明人： Jennifer Marie Mataraza , Andrea Van Elsas , Alan J. Korman , Edward L. Halk , Kent B. Thudium , Mark J. Selby , Timothy W. Sproul , Heidi N. Leblanc
摘要： The present invention relates to binding compounds specific for BTLA and uses thereof. More specifically, the invention relates to fully human antibodies that recognize human BTLA and modulate its activity in cancer, inflammatory, and autoimmune disorders.
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公开(公告)号：US20160257753A1
公开(公告)日：2016-09-08
申请号：US15163332
申请日：2016-05-24
IPC分类号： C07K16/28
CPC分类号： C07K16/2818 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/025 , A01K2267/03 , A01K2267/0325 , A01K2267/0381 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C12N15/8509 , Y02A50/386 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466 , Y02A50/487 , Y02A50/489
摘要： The presently subject matter provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
摘要翻译： 目前的主题提供了针对人CTLA-4的新型人序列抗体以及使用这些抗体治疗人类疾病，感染和其他病症的方法。
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