公开(公告)号：US20180141964A1

公开(公告)日：2018-05-24

申请号：US15876464

申请日：2018-01-22

申请人： EAST CHINA NORMAL UNIVERSITY

发明人： Jian ZHOU ,  Xingping ZENG

IPC分类号： C07F7/08

CPC分类号： C07F7/0803 ,  C07C45/516 ,  C07C45/64 ,  C07C67/11 ,  C07C2601/14 ,  C07F7/081 ,  C07F7/1804 ,  G01N30/02 ,  G01N2030/884 ,  C07C49/245 ,  C07C49/248 ,  C07C49/173 ,  C07C49/24 ,  C07C69/16

摘要： The present teachings relate to a functionalized silyl cyanide and synthetic methods thereof. As an example, the method may include adding a raw material silane and a cyanide source MCN in an organic solvent to produce the functionalized silyl cyanide in the absence of catalyst or in the presence of a metal salt catalyst. The functionalized silyl cyanide may be used in the reactions that classic TMSCN participates in, to synthesize important intermediates (e.g., cyanohydrin, amino alcohols and α-amino nitrile compounds), with improved reactivity and selectivity. The cyanosilyl ether resulted from the nucleophilic addition of functionalized silyl cyanide to aldehyde or ketone may undergo intramolecular reaction under appropriate conditions to transfer the functional groups on silicon onto the other parts of the product linked to silicon. Such a functional group transfer process may increase the synthesis efficiency and atom economy, as well as afford products unobtainable using traditional TMSCN.