公开(公告)号：US20200248069A1

公开(公告)日：2020-08-06

申请号：US16652208

申请日：2018-09-29

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Linyong Zhu ,  Yi Yang ,  Bingkun Bao ,  Chenxia Zhang ,  Dasheng Zhang ,  Chunyan Bao ,  Qiuning Lin ,  Ningfeng Li ,  Xin Hua ,  Yongliang Zhao ,  Renmei Liu ,  Zhengda Chen ,  Yuying Sun

IPC分类号： C09K11/07 ,  G01N33/68 ,  G01N33/58 ,  C07C255/23 ,  C07D263/54 ,  C07D277/64 ,  C07D233/96 ,  C07D307/68 ,  C07D495/04 ,  C07D333/60 ,  C07D413/06 ,  C07D409/06 ,  C07D417/06 ,  C07D215/38 ,  C07D401/06 ,  C07D495/14

摘要： Provided are a fluorescent probe, a preparation method therefor and a use thereof. The fluorescent probe responds to viscosity sensitively and specifically, can be used for the specific fluorescence labeling of proteins and can also be used in the quantification, detection or kinetic study of proteins and the imaging of cells, tissues and living bodies.

公开(公告)号：US20190187144A1

公开(公告)日：2019-06-20

申请号：US16318868

申请日：2017-07-18

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Linyong Zhu ,  Yi Yang ,  Dasheng Zhang ,  Zengmin Du ,  Bingkun Bao ,  Qiuning Lin ,  Xianjun Chen ,  Lipeng Yang ,  Chunyan Bao ,  Yihui Ge ,  Renmei Liu ,  Zhengda Chen ,  Sitong Zhang ,  Ningfeng Li ,  Xin Hua

IPC分类号： G01N33/58 ,  G01N33/533 ,  C09K11/06 ,  A61K49/00 ,  G01N21/64 ,  C07D487/04 ,  C07D263/56 ,  C07D277/64 ,  C07D495/04 ,  C07F7/08 ,  C07D409/14

CPC分类号： G01N33/582 ,  A61K49/00 ,  A61K49/0017 ,  C07D263/56 ,  C07D277/64 ,  C07D409/14 ,  C07D473/18 ,  C07D487/04 ,  C07D495/04 ,  C07F7/0816 ,  C09K11/06 ,  G01N21/6428 ,  G01N33/533

摘要： Provided are a fluorescent probe and a preparation process and the use thereof. The fluorescent probe is sensitive and specific to viscosity, and can be used for specific fluorescent labeling of proteins, and can also be used for quantification, detection or kinetic studies of proteins, and the imaging of cells, tissues and living bodies.

公开(公告)号：US20190241584A1

公开(公告)日：2019-08-08

申请号：US16318762

申请日：2017-07-18

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Linyong Zhu ,  Yi Yang ,  Dasheng Zhang ,  Zengmin Du ,  Bingkun Bao ,  Qiuning Lin ,  Yan Li ,  Xianjun Chen ,  Lipeng Yang ,  Chunyan Bao

IPC分类号： C07D495/04 ,  C07D333/78 ,  C07D495/14 ,  C09B57/00 ,  G01N33/68 ,  C12Q1/68 ,  G01N33/533 ,  C09B23/04 ,  C09B23/01

CPC分类号： C07D495/04 ,  A61K49/00 ,  C07D333/60 ,  C07D333/78 ,  C07D495/14 ,  C09B23/0058 ,  C09B23/0091 ,  C09B23/04 ,  C09B57/00 ,  C09K11/06 ,  C12Q1/68 ,  G01N33/533 ,  G01N33/68

摘要： Provided are a fluorescent dye and a preparation process and use thereof. The fluorescent dye is able to emit a long wavelength, is sensitive and specific to viscosity, and is used for a wide range of purposes, such as viscosity testing, fluorescent labeling, quantification or detection of proteins, enzymes or nucleic acids. In addition, it can be used as a fluorescent-activated probe.