公开(公告)号：US20200248069A1

公开(公告)日：2020-08-06

申请号：US16652208

申请日：2018-09-29

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Linyong Zhu ,  Yi Yang ,  Bingkun Bao ,  Chenxia Zhang ,  Dasheng Zhang ,  Chunyan Bao ,  Qiuning Lin ,  Ningfeng Li ,  Xin Hua ,  Yongliang Zhao ,  Renmei Liu ,  Zhengda Chen ,  Yuying Sun

IPC: C09K11/07 ,  G01N33/68 ,  G01N33/58 ,  C07C255/23 ,  C07D263/54 ,  C07D277/64 ,  C07D233/96 ,  C07D307/68 ,  C07D495/04 ,  C07D333/60 ,  C07D413/06 ,  C07D409/06 ,  C07D417/06 ,  C07D215/38 ,  C07D401/06 ,  C07D495/14

Abstract: Provided are a fluorescent probe, a preparation method therefor and a use thereof. The fluorescent probe responds to viscosity sensitively and specifically, can be used for the specific fluorescence labeling of proteins and can also be used in the quantification, detection or kinetic study of proteins and the imaging of cells, tissues and living bodies.

公开(公告)号：US20230296617A1

公开(公告)日：2023-09-21

申请号：US17904503

申请日：2021-02-09

Applicant: East China University of Science and Technology

Inventor： Yi Yang ,  Yuzheng Zhao ,  Chenxia Zhang ,  Li Huang ,  Yejun Zou ,  Xie Li ,  Shuning Liu

IPC: G01N33/68 ,  G01N33/58 ,  C12N15/63

CPC classification number: G01N33/6812 ,  G01N33/582 ,  C12N15/63

Abstract: Disclosed is a tryptophan optical probe, a preparation method therefor and the use thereof. Disclosed is an optical probe, comprising a tryptophan-sensitive polypeptide or a functional variant thereof and an optically active polypeptide or a functional variant thereof, wherein the optically active polypeptide or the functional variant thereof is located in the sequence of the tryptophan-sensitive polypeptide or the functional variant thereof. Furthermore, disclosed are a method for preparing the above-mentioned probe and the use thereof in the detection of tryptophan.