公开(公告)号：US20240017079A1

公开(公告)日：2024-01-18

申请号：US18331781

申请日：2023-06-08

申请人： EBR Systems, Inc.

发明人： David F. Moore ,  Paul Mohr ,  Nathaniel Parker Willis ,  Axel F. Brisken

IPC分类号： A61N1/378 ,  A61N1/375 ,  A61N1/362 ,  A61N1/372 ,  H02N2/18 ,  H10N30/03 ,  H10N30/30 ,  A61N1/02 ,  A61N1/05

CPC分类号： A61N1/3787 ,  A61N1/3758 ,  A61N1/3756 ,  A61N1/362 ,  A61N1/37205 ,  H02N2/181 ,  H02N2/186 ,  H02N2/188 ,  H10N30/03 ,  H10N30/30 ,  A61N1/02 ,  A61N1/05 ,  Y10T29/42 ,  A61B2560/0214

摘要： A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue.

公开(公告)号：US11752352B2

公开(公告)日：2023-09-12

申请号：US16879530

申请日：2020-05-20

申请人： EBR Systems, Inc.

发明人： David F. Moore ,  Mark W. Cowan ,  Nathaniel Parker Willis

IPC分类号： A61N1/378 ,  A61N1/372 ,  A61N1/375 ,  A61N1/362 ,  A61B5/283 ,  A61N1/37 ,  A61B17/34

CPC分类号： A61N1/3787 ,  A61B5/283 ,  A61N1/362 ,  A61N1/3702 ,  A61N1/3756 ,  A61N1/37205 ,  A61B17/3468 ,  A61N1/37223

摘要： Delivery of an implantable wireless receiver-stimulator (R-S) into the heart using delivery catheter is described. R-S comprises a cathode and an anode and wirelessly receives and converts energy, such as acoustic ultrasound energy, to electrical energy to stimulate the heart. Conductive wires routed through the delivery system temporarily connect R-S electrodes to external monitor and pacing controller. R-S comprises a first temporary electrical connection from the catheter to the cathode, and a second temporary electrical connection from the catheter to the anode. Temporary electrical connections allow external monitoring of heart's electrical activity as sensed by R-S electrodes to determine tissue viability for excitation as well as to assess energy conversion efficiency.

公开(公告)号：US20190151667A1

公开(公告)日：2019-05-23

申请号：US16250943

申请日：2019-01-17

申请人： EBR Systems, Inc.

发明人： David F. Moore ,  Paul Mohr ,  N. Parker Willis ,  Axel F. Brisken

IPC分类号： A61N1/378 ,  A61N1/375 ,  A61N1/05 ,  A61N1/372 ,  A61N1/362 ,  H01L41/25 ,  H02N2/18 ,  A61N1/02 ,  H01L41/113

CPC分类号： A61B2560/0214 ,  A61N1/02 ,  A61N1/05 ,  A61N1/362 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3787 ,  H01L41/113 ,  H01L41/25 ,  H02N2/181 ,  H02N2/186 ,  H02N2/188 ,  Y10T29/42

摘要： A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue.Furthermore, the controller-transmitter estimates the output voltage that is delivered to the tissue by the implanted receiver-stimulator. The controller-transmitter measures a query spike voltage resulting from the electrical energy delivered to the tissue by the receiver-stimulator, and computes a ratio of the predetermined maximum output voltage and a maximum query spike voltage. The maximum query spike voltage is computed by detecting a query spike voltage plateau. Based on this ratio, the controller-transmitter uses a measured query spike voltage to estimate the output voltage delivered by the receiver-stimulator to tissue.

公开(公告)号：US11712572B2

公开(公告)日：2023-08-01

申请号：US17030846

申请日：2020-09-24

申请人： EBR Systems, Inc.

发明人： David F. Moore ,  Paul Mohr ,  N. Parker Willis ,  Axel F. Brisken

IPC分类号： A61N1/362 ,  A61N1/378 ,  A61N1/375 ,  A61N1/372 ,  H02N2/18 ,  H10N30/03 ,  H10N30/30 ,  A61N1/02 ,  A61N1/05

CPC分类号： A61N1/3787 ,  A61N1/02 ,  A61N1/05 ,  A61N1/362 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/37205 ,  H02N2/181 ,  H02N2/186 ,  H02N2/188 ,  H10N30/03 ,  H10N30/30 ,  A61B2560/0214 ,  Y10T29/42

摘要： A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue.

公开(公告)号：US10688307B2

公开(公告)日：2020-06-23

申请号：US15878237

申请日：2018-01-23

申请人： EBR Systems, Inc.

发明人： David F. Moore ,  Mark W. Cowan ,  N. Parker Willis

IPC分类号： A61N1/378 ,  A61B5/042 ,  A61N1/372 ,  A61N1/375 ,  A61N1/362 ,  A61N1/37 ,  A61B17/34

摘要： Delivery of an implantable wireless receiver-stimulator (R-S) into the heart using delivery catheter is described. R-S comprises a cathode and an anode and wirelessly receives and converts energy, such as acoustic ultrasound energy, to electrical energy to stimulate the heart. Conductive wires routed through the delivery system temporarily connect R-S electrodes to external monitor and pacing controller. R-S comprises a first temporary electrical connection from the catheter to the cathode, and a second temporary electrical connection from the catheter to the anode. Temporary electrical connections allow external monitoring of heart's electrical activity as sensed by R-S electrodes to determine tissue viability for excitation as well as to assess energy conversion efficiency.

公开(公告)号：US09180285B2

公开(公告)日：2015-11-10

申请号：US14059228

申请日：2013-10-21

申请人： EBR Systems, Inc.

发明人： David F. Moore ,  Paul Mohr ,  N. Parker Willis ,  Axel F. Brisken

IPC分类号： A61N1/365 ,  A61N1/02 ,  A61N1/378 ,  A61N1/375 ,  H01L41/113 ,  H02N2/18 ,  H01L41/25 ,  A61N1/362 ,  A61N1/372

CPC分类号： A61N1/3787 ,  A61B2560/0214 ,  A61N1/02 ,  A61N1/05 ,  A61N1/362 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  H01L41/113 ,  H01L41/25 ,  H02N2/181 ,  H02N2/186 ,  H02N2/188 ,  Y10T29/42

摘要： Receiver-stimulator with folded or rolled up assembly of piezoelectric components, causing the receiver-stimulator to operate with a high degree of isotropy are disclosed. The receiver-stimulator comprises piezoelectric components, rectifier circuitry, and at least two stimulation electrodes. Isotropy allows the receiver-stimulator to be implanted with less concern regarding the orientation relative the transmitted acoustic field from an acoustic energy source.

摘要翻译： 具有压电元件的折叠或卷起组件的接收器 - 刺激器被公开，使得接收器 - 刺激器以高度的各向同性运行。 接收器 - 刺激器包括压电元件，整流电路和至少两个刺激电极。 各向同性允许接收器 - 刺激器被植入，而不考虑相对于来自声能源的传输声场的取向。

公开(公告)号：US20140046420A1

公开(公告)日：2014-02-13

申请号：US14059228

申请日：2013-10-21

申请人： EBR Systems, Inc.

发明人： David F. Moore ,  Paul Mohr ,  N. Parker Willis ,  Axel F. Brisken

IPC分类号： A61N1/02 ,  H01L41/25

CPC分类号： A61N1/3787 ,  A61B2560/0214 ,  A61N1/02 ,  A61N1/05 ,  A61N1/362 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  H01L41/113 ,  H01L41/25 ,  H02N2/181 ,  H02N2/186 ,  H02N2/188 ,  Y10T29/42

摘要： Receiver-stimulator with folded or rolled up assembly of piezoelectric components, causing the receiver-stimulator to operate with a high degree of isotropy are disclosed. The receiver-stimulator comprises piezoelectric components, rectifier circuitry, and at least two stimulation electrodes. Isotropy allows the receiver-stimulator to be implanted with less concern regarding the orientation relative the transmitted acoustic field from an acoustic energy source.

摘要翻译： 具有压电元件的折叠或卷起组件的接收器 - 刺激器被公开，使得接收器 - 刺激器以高度的各向同性运行。 接收器 - 刺激器包括压电元件，整流电路和至少两个刺激电极。 各向同性允许接收器 - 刺激器被植入，而不考虑相对于来自声能源的传输声场的取向。

公开(公告)号：US20210146143A1

公开(公告)日：2021-05-20

申请号：US17030846

申请日：2020-09-24

申请人： EBR Systems, Inc.

发明人： David F. Moore ,  Paul Mohr ,  N. Parker Willis ,  Axel F. Brisken

IPC分类号： A61N1/378 ,  A61N1/375 ,  A61N1/372 ,  H01L41/113 ,  H02N2/18 ,  A61N1/02 ,  H01L41/25 ,  A61N1/05

摘要： Receiver-stimulator with folded or rolled up assembly of piezoelectric components, causing the receiver-stimulator to operate with a high degree of isotropy are disclosed. The receiver-stimulator comprises piezoelectric components, rectifier circuitry, and at least two stimulation electrodes. Isotropy allows the receiver-stimulator to be implanted with less concern regarding the orientation relative the transmitted acoustic field from an acoustic energy source.

公开(公告)号：US10806938B2

公开(公告)日：2020-10-20

申请号：US16051338

申请日：2018-07-31

申请人： EBR Systems, Inc.

发明人： David F. Moore ,  Paul Mohr ,  N. Parker Willis ,  Axel F. Brisken

IPC分类号： A61N1/378 ,  A61N1/375 ,  A61N1/372 ,  H01L41/113 ,  H02N2/18 ,  A61N1/02 ,  H01L41/25 ,  A61N1/05 ,  A61N1/362

摘要： Receiver-stimulator with folded or rolled up assembly of piezoelectric components, causing the receiver-stimulator to operate with a high degree of isotropy are disclosed. The receiver-stimulator comprises piezoelectric components, rectifier circuitry, and at least two stimulation electrodes. Isotropy allows the receiver-stimulator to be implanted with less concern regarding the orientation relative the transmitted acoustic field from an acoustic energy source.

公开(公告)号：US09907968B2

公开(公告)日：2018-03-06

申请号：US15043210

申请日：2016-02-12

申请人： EBR Systems, Inc.

发明人： David F. Moore ,  Mark W. Cowan ,  N. Parker Willis

IPC分类号： A61N1/378 ,  A61B5/042 ,  A61N1/362 ,  A61N1/372 ,  A61N1/375 ,  A61N1/37 ,  A61B17/34

CPC分类号： A61N1/3787 ,  A61B5/042 ,  A61B17/3468 ,  A61N1/362 ,  A61N1/3702 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3756

摘要： Delivery of an implantable wireless receiver-stimulator (R-S) into the heart using delivery catheter is described. R-S comprises a cathode and an anode and wirelessly receives and converts energy, such as acoustic ultrasound energy, to electrical energy to stimulate the heart. Conductive wires routed through the delivery system temporarily connect R-S electrodes to external monitor and pacing controller. R-S comprises a first temporary electrical connection from the catheter to the cathode, and a second temporary electrical connection from the catheter to the anode. Temporary electrical connections allow external monitoring of heart's electrical activity as sensed by R-S electrodes to determine tissue viability for excitation as well as to assess energy conversion efficiency.