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公开(公告)号：US20190269917A1
公开(公告)日：2019-09-05
申请号：US16292227
申请日：2019-03-04
发明人： Gregoire Courtine , Nikolaus Wenger , Eduardo Martin Moraud , Silvestro Micera , Marco Bonizzato
IPC分类号： A61N1/36 , A61B5/11 , A61N1/05 , A61B5/04 , A61B5/0476 , A61B5/0488 , A61B5/00
摘要： The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.
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公开(公告)号：US10265525B2
公开(公告)日：2019-04-23
申请号：US15033063
申请日：2014-10-29
发明人： Gregoire Courtine , Nikolaus Wenger , Eduardo Martin Moraud , Silvestro Micera , Marco Bonizzato
IPC分类号： A61B5/04 , A61B5/11 , A61N1/05 , A61B5/0476 , A61B5/0488 , A61N1/36 , A61B5/00
摘要： The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.
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公开(公告)号：US11202911B2
公开(公告)日：2021-12-21
申请号：US16292227
申请日：2019-03-04
发明人： Gregoire Courtine , Nikolaus Wenger , Eduardo Martin Moraud , Silvestro Micera , Marco Bonizzato
IPC分类号： A61N1/36 , A61B5/11 , A61N1/05 , A61B5/04 , A61B5/0476 , A61B5/0488 , A61B5/00 , A61B5/24 , A61B5/369 , A61B5/389
摘要： The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.
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公开(公告)号：US10279167B2
公开(公告)日：2019-05-07
申请号：US15717738
申请日：2017-09-27
发明人： Grégoire Courtine , Nikolaus Wenger , Eduardo Martin Moraud , Silvestro Micera , Marco Bonizzato
IPC分类号： A61N1/05 , A61B5/11 , A61N1/36 , A61B5/04 , A61B5/0488 , A61B5/0476 , A61B5/00
摘要： The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising electrodes for applying to a subject neuromodulation with adjustable stimulation parameters, the electrodes being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with the electrodes said and providing the electrodes with new stimulation parameters, with minimum delay. The system of the disclosure improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), a multiple input-single output (MISO) model, or a multiple input-multiple output (MIMO) model.
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公开(公告)号：US20180117318A1
公开(公告)日：2018-05-03
申请号：US15340728
申请日：2016-11-01
发明人： Tomislav Milekovic , Marco Capogrosso , Gregoire Courtine , Eduardo Martin Moraud , Fabien Wagner , Jerome Gandar
IPC分类号： A61N1/36 , A61B5/04 , A61B5/0476 , A61B5/00
摘要： Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a first mode where one or more nerve fibers are not stimulated, and during a second mode where the one or more nerve fibers are stimulated. Delivery timing of electrical stimulation may be closed-loop controlled based on current motor cortex activity and the motor cortex activity recorded previously during both the first and second modes.
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公开(公告)号：US10668280B2
公开(公告)日：2020-06-02
申请号：US15340728
申请日：2016-11-01
发明人： Tomislav Milekovic , Marco Capogrosso , Gregoire Courtine , Eduardo Martin Moraud , Fabien Wagner , Jerome Gandar
IPC分类号： A61N1/36 , A61B5/0482 , A61B5/00 , A61B5/04 , A61B5/0476 , A61N1/04 , A61B5/0484 , A61N1/05 , A61F2/54 , A61B5/0488 , A61B5/055 , A61F2/60
摘要： Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a first mode where one or more nerve fibers are not stimulated, and during a second mode where the one or more nerve fibers are stimulated. Delivery timing of electrical stimulation may be closed-loop controlled based on current motor cortex activity and the motor cortex activity recorded previously during both the first and second modes.
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7.发明申请SYSTEM TO DELIVER ADAPTIVE EPIDURAL AND/OR SUBDURAL ELECTRICAL SPINAL CORD STIMULATION TO FACILITATE AND RESTORE LOCOMOTION AFTER A NEUROMOTOR IMPAIRMENT 审中-公开系统提供自适应膈肌和/或子系统电动脊髓刺激，以便在神经元损伤后进行修复和恢复机械公开(公告)号：US20160279418A1
公开(公告)日：2016-09-29
申请号：US15033063
申请日：2014-10-29
发明人： Gregoire Courtine , Nikolaus Wenger , Eduardo Martin Moraud , Silvestro Micera , Marco Bonizzato
IPC分类号： A61N1/36 , A61B5/11 , A61N1/05 , A61B5/04 , A61B5/0476 , A61B5/00 , A61B5/0488
CPC分类号： A61N1/36067 , A61B5/04001 , A61B5/0476 , A61B5/0488 , A61B5/112 , A61B5/1121 , A61B5/1127 , A61B5/4836 , A61B5/7282 , A61B2562/0219 , A61B2562/0247 , A61N1/0551 , A61N1/36003 , A61N1/36103 , A61N1/36135 , A61N1/36139
摘要： The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.
摘要翻译： 本发明提供了一种用于硬膜外和/或硬膜下电刺激的实时控制的闭环系统，包括：用可调刺激参数对受试者进行神经调节的装置，所述装置与包括传感器的实时监测部件 所述信号是提供所述对象运动特征的神经信号和/或信号，所述系统与接收所述反馈信号的信号处理设备和操作实时自动控制算法可操作地连接，所述信号 处理装置与所述装置可操作地连接，并以最小的延迟向所述装置提供新的刺激参数。 本发明的系统提高了在具有神经运动障碍的受试者中行走的一致性。 使用实时自动控制算法，其包括采用单输入单输出模型（SISO）或多输入单输出（MISO）模型的前馈分量。
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