公开(公告)号：US20200147135A1

公开(公告)日：2020-05-14

申请号：US16616087

申请日：2018-05-24

Applicant: EFFECTOR THERAPEUTICS, INC.

Inventor： Peggy A. THOMPSON ,  Kevin R. WEBSTER

IPC: A61K35/17 ,  A61K31/4355 ,  A61K45/06 ,  A61K31/343 ,  A61P35/00

Abstract: The present disclosure provides compositions and methods for improving an antitumor response against non-inflamed solid tumors. Methods of this disclosure include use of an eIF4A inhibitor to promote infiltration of antitumor lymphocytes into a non inflamed solid tumor. Methods of treating cancer associated with a non-inflamed solid tumor are also provided.

公开(公告)号：US20190038657A1

公开(公告)日：2019-02-07

申请号：US15973281

申请日：2018-05-07

Applicant: eFFECTOR Therapeutics, Inc.

Inventor： James APPLEMAN ,  Peggy A. THOMPSON

IPC: A61K31/713 ,  A61K31/4418 ,  A61K31/16 ,  A61K31/357 ,  A61K31/4245 ,  A61K31/436 ,  A61K31/155 ,  A61K31/496 ,  A61K31/519 ,  A61K31/706 ,  A61K45/06

CPC classification number: A61K31/713 ,  A61K31/155 ,  A61K31/16 ,  A61K31/165 ,  A61K31/357 ,  A61K31/4245 ,  A61K31/436 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/519 ,  A61K31/706 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure relates to compositions and methods for treating or preventing a fibrotic disorder or disease.