公开(公告)号：US20240082190A1

公开(公告)日：2024-03-14

申请号：US18273684

申请日：2022-01-24

申请人： EGIS GYÓGYSZERGYÁR ZRT.

发明人： Anita GULYÁS ,  Krisztina MÓRICZ, ,  Dániel ULEJ ,  Gábor GIGLER ,  Edit PAPP ,  Adrienn PÁLVÖLGYI ,  István GACSÁLYI ,  Zoltán VARGA ,  András Ferenc WACHA ,  Attila BÓTA,

IPC分类号： A61K31/197 ,  A61K9/00 ,  A61K9/06 ,  A61K47/24 ,  A61P25/04

CPC分类号： A61K31/197 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/24 ,  A61P25/04

摘要： The present invention relates to a topical pharmaceutical composition comprising pregabalin and a reduced micellar phospholipid as an active ingredient, which results in a prolonged analgesic effect of pregabalin. The product can reduce neuropathic pain by at least 5 hours.

公开(公告)号：US20240091138A1

公开(公告)日：2024-03-21

申请号：US18273575

申请日：2022-01-24

申请人： EGIS GYÓGYSZERGYÁR ZRT.

发明人： Anita GULYÁS ,  Krisztina MÓRICZ ,  Dániel ULEJ ,  Gábor GIGLER ,  Edit PAPP ,  Adrienn PÁLVÖLGYI ,  István GACSÁLYI

IPC分类号： A61K9/00 ,  A61K31/197 ,  A61K47/24 ,  A61P29/00

CPC分类号： A61K9/0014 ,  A61K31/197 ,  A61K47/24 ,  A61P29/00

摘要： Topical formulation containing pregabalin for long-term analgesic activity. The composition is prepared using high pressure homogenization, which changes the structure of the composition. The analgesic effect of the compounds of the present invention is significantly increased compared to reference formulations homogenized with equipment of the same quantitative composition but less shearing forces.

公开(公告)号：US20240082192A1

公开(公告)日：2024-03-14

申请号：US18273700

申请日：2022-01-24

申请人： EGIS GYÓGYSZERGYÁR ZRT.

发明人： Anita GULYÁS ,  Krisztina MÓRICZ ,  Dániel ULEJ ,  Gábor GIGLER ,  Edit PAPP ,  Adrienn PÁLVÖLGYI ,  István GACSÁLYI ,  Zoltán VARGA ,  András Ferenc WACHA ,  Attila BÓTA

IPC分类号： A61K31/197 ,  A61K9/06 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/24 ,  A61K47/32 ,  A61K47/44 ,  A61P25/02 ,  A61P29/00

CPC分类号： A61K31/197 ,  A61K9/06 ,  A61K47/10 ,  A61K47/183 ,  A61K47/22 ,  A61K47/24 ,  A61K47/32 ,  A61K47/44 ,  A61P25/02 ,  A61P29/00

摘要： Topical formulation containing pregabalin for long-term analgesic activity. The composition is prepared using high shear mixers or homogenizers such as HPH or ultrasonic devices, which changes the structure of the composition. The analgesic effect of the compounds of the present invention is significantly increased compared to reference formulations homogenized with equipment of the same quantitative composition but less shearing forces.

公开(公告)号：US20240082191A1

公开(公告)日：2024-03-14

申请号：US18273694

申请日：2022-01-24

申请人： EGIS GYÓGYSZERGYÁR ZRT.

发明人： Anita GULYÁS ,  Krisztina MÓRICZ ,  Dániel ULEJ ,  Gábor GIGLER ,  Edit PAP ,  Adrienn PÁLVÖLGYI ,  István GACSÁLYI ,  Zoltán VARGA ,  András Ferenc WACHA ,  Attila BÓTA

IPC分类号： A61K31/197 ,  A61K9/00 ,  A61K9/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/30 ,  A61K47/32 ,  A61P25/04

CPC分类号： A61K31/197 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/183 ,  A61K47/22 ,  A61K47/30 ,  A61K47/32 ,  A61P25/04

摘要： The present invention relates to a topical pharmaceutical composition comprising pregabalin and a reduced micellar phospholipid as an active ingredient, which results in a prolonged analgesic effect of pregabalin. The product can reduce neuropathic pain by at least 5 hours.