公开(公告)号：US09695188B2

公开(公告)日：2017-07-04

申请号：US15059965

申请日：2016-03-03

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yongbo Hu ,  Huiming Zhang ,  Hiroyuki Chiba ,  Yuki Komatsu ,  Bryan M. Lewis

IPC: C07D321/00 ,  C07D493/22

CPC classification number: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

公开(公告)号：US10450324B2

公开(公告)日：2019-10-22

申请号：US16031629

申请日：2018-07-10

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Yongbo Hu ,  Huiming Zhang ,  Hiroyuki Chiba ,  Yuki Komatsu ,  Bryan M. Lewis

IPC: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

公开(公告)号：US10030032B2

公开(公告)日：2018-07-24

申请号：US15638493

申请日：2017-06-30

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Yongbo Hu ,  Huiming Zhang ,  Hiroyuki Chiba ,  Yuki Komatsu ,  Bryan M. Lewis

IPC: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).