公开(公告)号：US10030032B2

公开(公告)日：2018-07-24

申请号：US15638493

申请日：2017-06-30

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Yongbo Hu ,  Huiming Zhang ,  Hiroyuki Chiba ,  Yuki Komatsu ,  Bryan M. Lewis

IPC: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

公开(公告)号：US09303039B2

公开(公告)日：2016-04-05

申请号：US14562086

申请日：2014-12-05

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Huiming Zhang ,  Bryan M. Lewis

IPC: C07D321/00 ,  C07D493/22

CPC classification number: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

Abstract translation: 通常，本发明的特征在于可用于合成软骨素B类似物的改进方法，例如胡椒素及其药学上可接受的盐（例如，甲磺酸eribulin）。

公开(公告)号：US10450324B2

公开(公告)日：2019-10-22

申请号：US16031629

申请日：2018-07-10

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Yongbo Hu ,  Huiming Zhang ,  Hiroyuki Chiba ,  Yuki Komatsu ,  Bryan M. Lewis

IPC: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

公开(公告)号：US08975422B2

公开(公告)日：2015-03-10

申请号：US14250086

申请日：2014-04-10

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Francis G. Fang ,  Bryan M. Lewis ,  Matthew Schnaderbeck

IPC: C07D493/20 ,  C07D307/28 ,  C07D307/33 ,  C07D407/06 ,  C07D407/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/18 ,  C07D493/22 ,  C07D493/10 ,  C07F7/18 ,  C07D317/72 ,  C07H15/26

CPC classification number: C07F7/1804 ,  A61K31/341 ,  C07C33/423 ,  C07D307/12 ,  C07D307/28 ,  C07D307/33 ,  C07D317/72 ,  C07D407/06 ,  C07D407/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/10 ,  C07D493/18 ,  C07D493/20 ,  C07D493/22 ,  C07F7/188 ,  C07H15/26 ,  Y02P20/55

Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.

Abstract translation: 提供了中间体及其在合成类软绵母B合成中的应用方法。

公开(公告)号：US09695188B2

公开(公告)日：2017-07-04

申请号：US15059965

申请日：2016-03-03

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yongbo Hu ,  Huiming Zhang ,  Hiroyuki Chiba ,  Yuki Komatsu ,  Bryan M. Lewis

IPC: C07D321/00 ,  C07D493/22

CPC classification number: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

公开(公告)号：USRE47797E1

公开(公告)日：2020-01-07

申请号：US15944480

申请日：2018-04-03

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Farid Benayoud ,  Trevor Lee Calkins ,  Charles E. Chase ,  William Christ ,  Bryan M. Lewis ,  Matthew Schnaderbeck ,  Marc Pesant ,  Brian Austad ,  Silvio Campagna ,  Yongbo Hu ,  Gordon Wilkie ,  Xiaojie Zhu ,  Francis G. Fang

IPC: C07D307/28 ,  C07F7/18 ,  C07C33/42 ,  C07D407/06 ,  C07D407/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/18 ,  C07D493/22 ,  C07D493/20 ,  C07D317/72 ,  C07H15/26 ,  A61K31/341 ,  C07D307/12 ,  C07D493/10 ,  C07D307/33

Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.

公开(公告)号：USRE46965E1

公开(公告)日：2018-07-24

申请号：US13924892

申请日：2013-06-24

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Brian Austad ,  Charles E. Chase ,  Francis G. Fang ,  Trevor Calkins ,  Bryan M. Lewis

IPC: C07D307/12 ,  C07F7/18 ,  C07D407/06 ,  C07D407/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/18 ,  C07D493/22 ,  C07D493/20 ,  C07D317/72 ,  C07H15/26 ,  C07C33/42 ,  A61K31/341 ,  C07D493/10 ,  C07D307/28 ,  C07D307/33

CPC classification number: C07F7/1804 ,  A61K31/341 ,  C07C33/423 ,  C07D307/12 ,  C07D307/28 ,  C07D307/33 ,  C07D317/72 ,  C07D407/06 ,  C07D407/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/10 ,  C07D493/18 ,  C07D493/20 ,  C07D493/22 ,  C07F7/188 ,  C07H15/26 ,  Y02P20/55

Abstract: The present invention provides macrocyclic compounds, synthesis of the same and intermediates thereto. Such compounds, and compositions thereof, are useful for treating or preventing proliferative disorders Formula (F-4).