公开(公告)号：US10030032B2

公开(公告)日：2018-07-24

申请号：US15638493

申请日：2017-06-30

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Yongbo Hu ,  Huiming Zhang ,  Hiroyuki Chiba ,  Yuki Komatsu ,  Bryan M. Lewis

IPC: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

公开(公告)号：US09029573B2

公开(公告)日：2015-05-12

申请号：US14058742

申请日：2013-10-21

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yongbo Hu

IPC: C07D321/00 ,  C07D493/22

Abstract: The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediate.

公开(公告)号：US10450324B2

公开(公告)日：2019-10-22

申请号：US16031629

申请日：2018-07-10

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Yongbo Hu ,  Huiming Zhang ,  Hiroyuki Chiba ,  Yuki Komatsu ,  Bryan M. Lewis

IPC: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

公开(公告)号：US09695188B2

公开(公告)日：2017-07-04

申请号：US15059965

申请日：2016-03-03

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yongbo Hu ,  Huiming Zhang ,  Hiroyuki Chiba ,  Yuki Komatsu ,  Bryan M. Lewis

IPC: C07D321/00 ,  C07D493/22

CPC classification number: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

公开(公告)号：USRE47797E1

公开(公告)日：2020-01-07

申请号：US15944480

申请日：2018-04-03

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Farid Benayoud ,  Trevor Lee Calkins ,  Charles E. Chase ,  William Christ ,  Bryan M. Lewis ,  Matthew Schnaderbeck ,  Marc Pesant ,  Brian Austad ,  Silvio Campagna ,  Yongbo Hu ,  Gordon Wilkie ,  Xiaojie Zhu ,  Francis G. Fang

IPC: C07D307/28 ,  C07F7/18 ,  C07C33/42 ,  C07D407/06 ,  C07D407/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/18 ,  C07D493/22 ,  C07D493/20 ,  C07D317/72 ,  C07H15/26 ,  A61K31/341 ,  C07D307/12 ,  C07D493/10 ,  C07D307/33

Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.

公开(公告)号：US09469651B2

公开(公告)日：2016-10-18

申请号：US14707763

申请日：2015-05-08

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yongbo Hu

IPC: C07D323/00 ,  C07D493/22

CPC classification number: C07D493/22 ,  C07B2200/13

Abstract: The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediates.

公开(公告)号：US09206194B2

公开(公告)日：2015-12-08

申请号：US14058742

申请日：2013-10-21

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yongbo Hu

IPC: C07D321/00 ,  C07D493/22

CPC classification number: C07D493/22 ,  C07B2200/13

Abstract: The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediate.

Abstract translation: 本发明包括具有药物活性的软骨素B类似物; 在一些情况下，其结晶形式，并且在一些情况下，具有作为合成中间体的进一步的效用的软氢键B类似物。