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公开(公告)号：US20230113505A1
公开(公告)日：2023-04-13
申请号：US18079853
申请日：2022-12-12
申请人： ELECTROCORE, INC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Methods and devices are disclosed for the non-invasive treatment of autoimmune diseases or disorders through the delivery of energy to target nervous tissue, particularly the vagus nerve.. A device for treating an autoimmune disease or disorder comprises one or more electrodes having a contact surface configured for contacting an anterior portion of an outer skin surface of a neck of a patient and an energy source coupled to the electrodes. The energy source is configured to generate one or more electrical impulses and to transmit the electrical impulses to the electrodes and transcutaneously through the anterior portion of the outer skin surface of the neck of the patient at or near a vagus nerve. The electrical impulses are sufficient to modulate the vagus nerve and to inhibit inflammation and treat the disorder.
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公开(公告)号：US11458297B2
公开(公告)日：2022-10-04
申请号：US16404443
申请日：2019-05-06
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
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公开(公告)号：US20220273939A1
公开(公告)日：2022-09-01
申请号：US17739100
申请日：2022-05-07
申请人： ELECTROCORE, INC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Systems and methods for treating diseases and disorders in a patient are provided. A device comprises a stimulator comprising an electrode and an energy source. The energy source is configured to generate an electrical impulse and transmit the electrical impulse to the electrode through an outer skin surface to a vagus nerve of the patient. The device further comprises a sensor for detecting a physiological parameter of a patient's heart and a controller coupled to the stimulator and the sensor and configured to activate the stimulator based on the physiological parameter to cause the stimulator to generate the electrical impulse. In some aspects, the electrical impulse is sufficient to modulate the vagus nerve to treat a cardiac arrhythmia of the patient.
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公开(公告)号：US20220217479A1
公开(公告)日：2022-07-07
申请号：US17702051
申请日：2022-03-23
申请人： ELECTROCORE, INC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
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公开(公告)号：US20210353943A1
公开(公告)日：2021-11-18
申请号：US17390747
申请日：2021-07-30
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Methods and devices are disclosed for the non-invasive treatment of Parkinson's disease through the delivery of energy to target nervous tissue, particularly the vagus nerve. The methods and devices transmit an electrical impulse transcutaneously through an outer skin surface of the patient to modulate activity of the vagus nerve to treat one or more symptoms of Parkinson's disease. This modulation may inhibit neuroinflammation and/or increase levels of at least one neurotrophic factor to promote the survival of dopamine producing cells in patients suffering from the conditions of Parkinson's disease.
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公开(公告)号：US11123545B2
公开(公告)日：2021-09-21
申请号：US16837818
申请日：2020-04-01
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a target nerve within the patient. The electrical signal comprises bursts of about 2 to about 20 pulses and the pulses oscillate between a positive voltage and a negative voltage within each burst.
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公开(公告)号：US20200078589A1
公开(公告)日：2020-03-12
申请号：US16662295
申请日：2019-10-24
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
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8.发明申请公开(公告)号：US20200038655A1
公开(公告)日：2020-02-06
申请号：US16597188
申请日：2019-10-09
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： A method for modulating a nerve within a body of a patient includes generating a single signal comprising an electrical impulse, contacting an interface with an outer skin surface of a patient and delivering the electrical impulse from an electrode through the interface and the outer skin surface of the patient to a vagus nerve, thereby modulating the vagus nerve. The electrical impulse may comprise bursts of pulses with a silent intra-burst interval between each of the bursts based on the single signal, wherein each of the bursts has a frequency of about 5 Hz to about 100 Hz and each of the pulses has a duration from about 50 microseconds to about 1000 microseconds. The electrode may be spaced from the interface by a distance of about 0.25 to about 4 times an outer dimension of the interface.
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公开(公告)号：US20190275327A1
公开(公告)日：2019-09-12
申请号：US16356639
申请日：2019-03-18
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.
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公开(公告)号：US11623080B2
公开(公告)日：2023-04-11
申请号：US17702051
申请日：2022-03-23
申请人： ELECTROCORE, INC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
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