公开(公告)号：US11975293B2

公开(公告)日：2024-05-07

申请号：US17655093

申请日：2022-03-16

Applicant: EMD Millipore Corporation

Inventor： Alison Dupont

IPC: B01D63/10 ,  B01D61/18 ,  C12M1/00 ,  B01D65/02 ,  B01D65/08

CPC classification number: B01D63/103 ,  C12M29/10 ,  B01D61/18 ,  B01D65/02 ,  B01D65/08 ,  B01D2311/04 ,  B01D2311/06 ,  B01D2313/143 ,  B01D2315/10 ,  C12M29/04

Abstract: Filter elements for perfusion systems and methods are provided. A filter element sheet includes a microporous membrane having a mean pore size of at least about 0.65 μm and a feed spacer comprising woven fibers and having an open area of at least about 35%. The filter element sheet can be arranged within a filter element, for example, in a spiral-wound format or in a cassette format. A perfusion system includes at least one filter element and a pump configured to control flow of a liquid feed through the at least one filter element.

公开(公告)号：US20220203303A1

公开(公告)日：2022-06-30

申请号：US17655093

申请日：2022-03-16

Applicant: EMD Millipore Corporation

Inventor： Alison Dupont

IPC: B01D63/10 ,  C12M1/00

Abstract: Filter elements for perfusion systems and methods are provided. A filter element sheet includes a microporous membrane having a mean pore size of at least about 0.65 μm and a feed spacer comprising woven fibers and having an open area of at least about 35%. The filter element sheet can be arranged within a filter element, for example, in a spiral-wound format or in a cassette format. A perfusion system includes at least one filter element and a pump configured to control flow of a liquid feed through the at least one filter element.

公开(公告)号：US20230001356A1

公开(公告)日：2023-01-05

申请号：US17772724

申请日：2020-11-17

Applicant: EMD Millipore Corporation

Inventor： Stefano Berti Perez ,  Alison Dupont

IPC: B01D61/18 ,  C12M1/00

Abstract: The disclosure herein relates to a TFF assembly including a baffle comprising a microporous filter within a bioreactor. The baffle may include a collection receptacle to capture a target product or waste materials within the baffle after passing through the microporous filter.

公开(公告)号：US20220119759A1

公开(公告)日：2022-04-21

申请号：US17073465

申请日：2020-10-19

Applicant: EMD Millipore Corporation

Inventor： Ying Li ,  Alison Dupont ,  Amy Wood ,  Allyson Fournier ,  Akshat Gupta ,  Hiral Gami

IPC: C12M1/00

Abstract: A multi-stage TFF apparatus, comprising a bioreactor capable of holding cell culture media; a first stage TFF device in fluid communication with the bioreactor; a storage tank in fluid communication with the first stage TFF device; a first recirculating loop in fluid communication with the first stage TFF device and the bioreactor; a second stage TFF device, in fluid communication with and downstream from the storage tank; and a second recirculating loop in fluid communication with the second stage TFF device and the storage tank.

公开(公告)号：US20240246034A1

公开(公告)日：2024-07-25

申请号：US18624011

申请日：2024-04-01

Applicant: EMD Millipore Corporation

Inventor： Alison Dupont

IPC: B01D63/10 ,  B01D61/18 ,  B01D63/08 ,  B01D65/02 ,  B01D65/08 ,  C12M1/00

CPC classification number: B01D63/103 ,  B01D63/0822 ,  B01D63/10 ,  C12M29/10 ,  B01D61/18 ,  B01D65/02 ,  B01D65/08 ,  B01D2311/04 ,  B01D2311/06 ,  B01D2311/25 ,  B01D2313/143 ,  B01D2315/10 ,  C12M29/04

Abstract: Filter elements for perfusion systems and methods are provided. A filter element sheet includes a microporous membrane having a mean pore size of at least about 0.65 μm and a feed spacer comprising woven fibers and having an open area of at least about 35%. The filter element sheet can be arranged within a filter element, for example, in a spiral-wound format or in a cassette format. A perfusion system includes at least one filter element and a pump configured to control flow of a liquid feed through the at least one filter element.