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公开(公告)号：US12076666B2
公开(公告)日：2024-09-03
申请号：US17312109
申请日：2020-03-26
Applicant: EMD Millipore Corporation
Inventor： Akshat Gupta , John Paul Amara , Kara M. Pizzelli , Shannon Ryan
CPC classification number: B01D24/10 , B01D39/1623 , B01D39/18 , B01D39/2068 , G01N1/34 , G01N1/4077 , B01D2201/182 , G01N2001/4088
Abstract: Depth filters with optimized head space are provided, as well as methods of optimizing the head space in depth filters, and methods of filtration with depth filters having optimized head space, including clarification of flocculated feed streams where pretreatment may include any of lowering cell culture pH, addition of polymers (uncharged or charged), or addition of salts to precipitate out solubilized impurities resulting in high insoluble biomass.
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公开(公告)号：US12053729B2
公开(公告)日：2024-08-06
申请号：US18334925
申请日：2023-06-14
Applicant: EMD Millipore Corporation
Inventor： Akshat Gupta , Dana Kinzlmaier , Kara Pizzelli , Elizabeth Goodrich
Abstract: Treatment methods for reduction of (1→3)-β-D-glucan leachables from cellulose-containing filter materials are described.
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公开(公告)号：US11691107B2
公开(公告)日：2023-07-04
申请号：US16762688
申请日：2018-11-01
Applicant: EMD Millipore Corporation
Inventor： Elizabeth M. Goodrich , Akshat Gupta , Herbert Lutz
CPC classification number: B01D61/146 , B01D61/18 , B01D61/22 , B01D65/02 , B01D2311/04 , B01D2311/08 , B01D2311/25 , B01D2313/18 , B01D2313/243 , B01D2313/50 , B01D2315/10 , B01D2315/14 , B01D2315/16 , B01D2317/022 , B01D2317/04 , B01D2321/16
Abstract: Processes and systems for filtering a liquid sample are provided. Batches of a liquid sample can be routed to two or more cycling tanks (e.g., first and second cycling tanks). Upon filling a first cycling tank, a first batch of the liquid sample can be routed to a filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the first cycling tank or to a collection vessel. Upon filling a second cycling tank, a second batch of the liquid sample is routed to the filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the second cycling tank or to the collection vessel. The filling and continuous diafiltration of batches of the liquid sample continues to alternate between the two or more cycling tanks until a total product volume is processed.
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公开(公告)号：US20230211291A1
公开(公告)日：2023-07-06
申请号：US18183609
申请日：2023-03-14
Applicant: EMD Millipore Corporation
Inventor： Elizabeth M. Goodrich , Akshat Gupta , Herbert Lutz
CPC classification number: B01D61/146 , B01D61/18 , B01D61/22 , B01D65/02 , B01D2311/04 , B01D2311/08 , B01D2311/25 , B01D2313/18 , B01D2313/243 , B01D2313/50 , B01D2315/10 , B01D2315/14 , B01D2315/16 , B01D2317/022 , B01D2317/04 , B01D2321/16
Abstract: Processes and systems for filtering a liquid sample are provided. Batches of a liquid sample can be routed to two or more cycling tanks (e.g., first and second cycling tanks). Upon filling a first cycling tank, a first batch of the liquid sample can be routed to a filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the first cycling tank or to a collection vessel. Upon filling a second cycling tank, a second batch of the liquid sample is routed to the filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the second cycling tank or to the collection vessel. The filling and continuous diafiltration of batches of the liquid sample continues to alternate between the two or more cycling tanks until a total product volume is processed.
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公开(公告)号：US20220119759A1
公开(公告)日：2022-04-21
申请号：US17073465
申请日：2020-10-19
Applicant: EMD Millipore Corporation
Inventor： Ying Li , Alison Dupont , Amy Wood , Allyson Fournier , Akshat Gupta , Hiral Gami
IPC: C12M1/00
Abstract: A multi-stage TFF apparatus, comprising a bioreactor capable of holding cell culture media; a first stage TFF device in fluid communication with the bioreactor; a storage tank in fluid communication with the first stage TFF device; a first recirculating loop in fluid communication with the first stage TFF device and the bioreactor; a second stage TFF device, in fluid communication with and downstream from the storage tank; and a second recirculating loop in fluid communication with the second stage TFF device and the storage tank.
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Patent Agency Ranking
公开(公告)号：US20210354055A1
公开(公告)日：2021-11-18
申请号：US17312109
申请日：2020-03-26
Applicant: EMD Millipore Corporation
Inventor： Akshat Gupta , John Paul Amara , Kara M. Pizzelli , Shannon Ryan
Abstract: Depth filters with optimized head space are provided, as well as methods of optimizing the head space in depth filters, and methods of filtration with depth filters having optimized head space, including clarification of flocculated feed streams where pretreatment may include any of lowering cell culture pH, addition of polymers (uncharged or charged), or addition of salts to precipitate out solubilized impurities resulting in high insoluble biomass.
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公开(公告)号：US20210236973A1
公开(公告)日：2021-08-05
申请号：US17235071
申请日：2021-04-20
Applicant: EMD Millipore Corporation
Inventor： Akshat Gupta , Dana Kinzlmaier , Kara Pizzelli , Elizabeth Goodrich
Abstract: Treatment methods for reduction of (1→3)-β-D-glucan leachables from cellulose-containing filter materials are described.
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公开(公告)号：US12128359B2
公开(公告)日：2024-10-29
申请号：US18183609
申请日：2023-03-14
Applicant: EMD Millipore Corporation
Inventor： Elizabeth M. Goodrich , Akshat Gupta , Herbert Lutz
CPC classification number: B01D61/149 , B01D61/18 , B01D61/22 , B01D65/02 , B01D2311/04 , B01D2311/08 , B01D2311/25 , B01D2313/18 , B01D2313/243 , B01D2313/50 , B01D2315/10 , B01D2315/14 , B01D2315/16 , B01D2317/022 , B01D2317/04
Abstract: Processes and systems for filtering a liquid sample are provided. Batches of a liquid sample can be routed to two or more cycling tanks (e.g., first and second cycling tanks). Upon filling a first cycling tank, a first batch of the liquid sample can be routed to a filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the first cycling tank or to a collection vessel. Upon filling a second cycling tank, a second batch of the liquid sample is routed to the filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the second cycling tank or to the collection vessel. The filling and continuous diafiltration of batches of the liquid sample continues to alternate between the two or more cycling tanks until a total product volume is processed.
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公开(公告)号：US20210170336A1
公开(公告)日：2021-06-10
申请号：US16762688
申请日：2018-11-01
Applicant: EMD Millipore Corporation
Inventor： Elizabeth M. Goodrich , Akshat Gupta , Herbert Lutz
Abstract: Processes and systems for filtering a liquid sample are provided. Batches of a liquid sample can be routed to two or more cycling tanks (e.g., first and second cycling tanks). Upon filling a first cycling tank, a first batch of the liquid sample can be routed to a filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the first cycling tank or to a collection vessel. Upon filling a second cycling tank, a second batch of the liquid sample is routed to the filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the second cycling tank or to the collection vessel. The filling and continuous diafiltration of batches of the liquid sample continues to alternate between the two or more cycling tanks until a total product volume is processed.
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公开(公告)号：US20230321574A1
公开(公告)日：2023-10-12
申请号：US18334925
申请日：2023-06-14
Applicant: EMD Millipore Corporation
Inventor： Akshat Gupta , Dana Kinzlmaier , Kara Pizzelli , Elizabeth Goodrich
Abstract: Treatment methods for reduction of (1→3)-β-D-glucan leachables from cellulose-containing filter materials are described.
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