公开(公告)号：US20220098233A1

公开(公告)日：2022-03-31

申请号：US17545419

申请日：2021-12-08

Applicant: EMD Millipore Corporation

Inventor： Matthew T. Stone ,  John P. Amara

IPC: C07K1/20 ,  C07K1/18 ,  C07K1/36 ,  B01D15/38 ,  B01D63/02

Abstract: The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.

公开(公告)号：US20170298091A1

公开(公告)日：2017-10-19

申请号：US15521428

申请日：2015-09-30

Applicant: EMD Millipore Corporation

Inventor： Matthew T. Stone ,  John P. Amara

IPC: C07K1/20 ,  B01D63/02 ,  B01D15/38 ,  C07K1/36 ,  C07K1/18

CPC classification number: C07K1/20 ,  B01D15/3804 ,  B01D63/02 ,  B01D2311/2626 ,  C07K1/18 ,  C07K1/36

Abstract: The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.

公开(公告)号：US20190389901A1

公开(公告)日：2019-12-26

申请号：US16561453

申请日：2019-09-05

Applicant: EMD Millipore Corporation

Inventor： Matthew T. Stone ,  John P. Amara

IPC: C07K1/20 ,  C07K1/18 ,  C07K1/36 ,  B01D15/38 ,  B01D63/02

Abstract: The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.

公开(公告)号：US11236125B2

公开(公告)日：2022-02-01

申请号：US16561453

申请日：2019-09-05

Applicant: EMD Millipore Corporation

Inventor： Matthew T. Stone ,  John P. Amara

IPC: C07K1/20 ,  C07K1/18 ,  C07K1/36 ,  B01D15/38 ,  B01D63/02

Abstract: The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.