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1.发明授权公开(公告)号：US10287314B2
公开(公告)日：2019-05-14
申请号：US14747029
申请日：2015-06-23
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak
IPC: B01D15/36 , B01D15/12 , B01D15/18 , B01D15/38 , B01J39/26 , B01J41/20 , C07K1/36 , C07K1/16 , B01J20/282 , C07K1/20 , B01J43/00 , B01J47/04 , C07K16/00 , B01J20/20
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
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公开(公告)号：US20170298091A1
公开(公告)日：2017-10-19
申请号：US15521428
申请日：2015-09-30
Applicant: EMD Millipore Corporation
Inventor： Matthew T. Stone , John P. Amara
CPC classification number: C07K1/20 , B01D15/3804 , B01D63/02 , B01D2311/2626 , C07K1/18 , C07K1/36
Abstract: The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.
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公开(公告)号：US20190389901A1
公开(公告)日：2019-12-26
申请号：US16561453
申请日：2019-09-05
Applicant: EMD Millipore Corporation
Inventor： Matthew T. Stone , John P. Amara
Abstract: The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.
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4.发明申请Methods of Reducing Level of One or More Impurities in a Sample During Protein Purification 审中-公开降低蛋白质纯化过程中样品中一种或多种杂质水平的方法公开(公告)号：US20160016992A1
公开(公告)日：2016-01-21
申请号：US14747029
申请日：2015-06-23
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak
CPC classification number: C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01J20/20 , B01J20/282 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/04 , C07K1/16 , C07K1/20 , C07K16/00 , C07K2317/10
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
Abstract translation: 本发明提供新颖和改进的蛋白质纯化方法，其包含某些类型的碳质材料，并且导致有效和选择性地除去某些不需要的杂质，而不会不利地影响所需蛋白质产物的产率。
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5.发明授权公开(公告)号：US11634457B2
公开(公告)日：2023-04-25
申请号：US16358845
申请日：2019-03-20
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak
IPC: B01D15/36 , C07K1/36 , C07K1/16 , B01D15/18 , C07K1/18 , C07K1/22 , C07K16/00 , B01J20/282 , C07K1/20 , B01D15/12 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/04 , B01J20/20 , B01D15/38
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely affecting the yield of the desired protein product.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20190218250A1
公开(公告)日：2019-07-18
申请号：US16358845
申请日：2019-03-20
Applicant: EMD Millipore Corporation
Inventor： Nanying Bian , Christopher Gillespie , Matthew T. Stone , Mikhail Kozlov , Jie Chen , Martin Siwak
IPC: C07K1/36 , B01J20/20 , B01D15/12 , B01D15/36 , C07K16/00 , B01J47/04 , B01J43/00 , B01J41/20 , B01J39/26 , C07K1/20 , C07K1/16 , B01J20/282
CPC classification number: C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01J20/20 , B01J20/282 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/04 , C07K1/16 , C07K1/20 , C07K16/00 , C07K2317/10
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely affecting the yield of the desired protein product.
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7.发明授权公开(公告)号：US09910041B2
公开(公告)日：2018-03-06
申请号：US14891727
申请日：2014-04-04
Applicant: EMD Millipore Corporation
Inventor： Matthew T. Stone , Ushma Mehta , Damon Asher , Patricia Greenhalgh
IPC: C07K16/00 , C07K1/36 , C07D471/02 , C07K1/16 , C07K1/18 , G01N33/569 , C07K1/20 , C07K1/22 , C12Q1/04 , C12Q1/06
CPC classification number: G01N33/56983 , C07K1/20 , C07K1/22 , C07K16/00 , C12Q1/04 , C12Q1/06 , G01N2333/015 , G01N2333/15
Abstract: The present invention provides methods for determining whether activated carbon can be used for removing viruses or a certain virus from a sample containing a target protein.
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公开(公告)号：US20170320909A1
公开(公告)日：2017-11-09
申请号：US15654876
申请日：2017-07-20
Applicant: EMD Millipore Corporation
Inventor： Alex Xenopoulos , Michael Phillips , Wilson Moya , Jad Jaber , Mikhail Kozlov , Ajish Potty , Matthew T. Stone , William Cataldo , Christopher Gillespie
CPC classification number: C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01D15/3847 , C07K16/00 , C07K2317/14 , C12M29/04 , C12M43/00 , C12M47/12 , C12N7/00
Abstract: The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner.
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公开(公告)号：US20150133636A1
公开(公告)日：2015-05-14
申请号：US14400389
申请日：2013-06-21
Applicant: EMD Millipore Corporation
Inventor： Alex Xenopoulos , Michael Phillips , Wilson Moya , Jad Jaber , Mikhail Kozlov , Ajish Potty , Matthew T. Stone , William Cataldo , Christopher Gillespie
CPC classification number: C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01D15/3847 , C07K16/00 , C07K2317/14 , C12M29/04 , C12M43/00 , C12M47/12 , C12N7/00
Abstract: The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner.
Abstract translation: 本发明涉及用于纯化生物分子的改进方法和系统，其中所述方法可以以连续的方式进行。
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公开(公告)号：US11472836B2
公开(公告)日：2022-10-18
申请号：US14768267
申请日：2014-02-11
Applicant: EMD Millipore Corporation
Inventor： Matthew T. Stone , Mikhail Kozlov
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
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