公开(公告)号：US20150060342A1

公开(公告)日：2015-03-05

申请号：US14535461

申请日：2014-11-07

Applicant: EMD Millipore Corporation

Inventor： Anthony J. DiLeo ,  Justin McCue ,  Wilson Moya ,  Igor Quinones-Garcia ,  Neil P. Soice ,  Volkmar Thom ,  Sarah Yuan

IPC: B01D15/20 ,  B01D15/26 ,  B01D15/36

CPC classification number: B01D15/20 ,  B01D15/265 ,  B01D15/361 ,  B01J20/26 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/28042 ,  B01J20/28078 ,  B01J20/28097 ,  B01J20/286 ,  B01J20/3064 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/328 ,  B01J20/3282 ,  B01J20/3289 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/58 ,  B01J2220/62

Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.

Abstract translation: 能够吸附过滤具有多孔自支撑基底和一种或多种多孔吸附聚合物涂层的多孔基底，其包含基底孔隙体积的约1至约80％。 所得到的底物具有良好的对流和扩散流量和容量。 底物可以是交联的，具有一个或多个捕获化学物质连接到其上，并且可用作用于选择性过滤所需物质（包括生物分子例如蛋白质和DNA片段）的色谱介质。