公开(公告)号：US20150056270A1

公开(公告)日：2015-02-26

申请号：US14386855

申请日：2013-03-22

申请人： Hiroki HAMADA ,  Ichiro FUJIWARA ,  ENSUIKO SUGAR REFINING CO., LTD. ,  NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

发明人： Hiroki Hamada ,  Ichiro Fujiwara ,  Masaharu Seno ,  Tomonari Kasai ,  Tsukasa Shigehiro ,  Masaharu Murakami ,  Katsuhiko Mikuni

IPC分类号： A61K47/48 ,  A61K31/337

摘要： In order to reduce the side effects of paclitaxel derivatives having excellent anti-cancer effects, an attempt was made to produce a liposome encapsulating paclitaxel derivatives such as paclitaxel monoglycosides and docetaxel monoglycosides. However, the introduction efficiency of paclitaxel derivatives, etc., into a liposome was poor, and this technique was not developed to a practical level. The present invention provides a method for producing a liposome encapsulating a paclitaxel monoglycoside and/or a docetaxel monoglycoside, and having an antibody specifically recognizing a cancer cell, the method comprising a step of bringing a liposome encapsulating a polyoxyethylene ester derivative, a lower alcohol, and a buffer or water into contact with a solution in which a paclitaxel monoglycoside and/or a docetaxel monoglycoside is dissolved in an alkylene glycol-containing buffer or water.

摘要翻译： 为了减少具有优异的抗癌作用的紫杉醇衍生物的副作用，尝试制备包封紫杉醇衍生物如紫杉醇单糖苷和多西紫杉醇单糖苷的脂质体。 然而，紫杉醇衍生物等在脂质体中的引入效率差，这种技术尚未发展到实用水平。 本发明提供一种包装紫杉醇单糖苷和/或多西紫杉醇单糖苷的脂质体的制造方法，其具有特异性识别癌细胞的抗体，所述方法包括使脂质体包封聚氧乙烯酯衍生物，低级醇， 以及缓冲液或水与其中将紫杉醇单糖苷和/或多西紫杉醇单糖苷溶解在含亚烷基二醇的缓冲液或水中的溶液接触。

公开(公告)号：US10682330B2

公开(公告)日：2020-06-16

申请号：US14386855

申请日：2013-03-22

申请人： ENSUIKO SUGAR REFINING CO., LTD. ,  Hiroki Hamada ,  Ichiro Fujiwara ,  NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

发明人： Hiroki Hamada ,  Ichiro Fujiwara ,  Masaharu Seno ,  Tomonari Kasai ,  Tsukasa Shigehiro ,  Masaharu Murakami ,  Katsuhiko Mikuni

IPC分类号： A61K31/337 ,  A61K47/26 ,  A61K9/127 ,  A61K31/7048 ,  C07K16/32 ,  A61K47/69 ,  A61K39/00

摘要： In order to reduce the side effects of paclitaxel derivatives having excellent anti-cancer effects, an attempt was made to produce a liposome encapsulating paclitaxel derivatives such as paclitaxel monoglycosides and docetaxel monoglycosides. However, the introduction efficiency of paclitaxel derivatives, etc., into a liposome was poor, and this technique was not developed to a practical level. The present invention provides a method for producing a liposome encapsulating a paclitaxel monoglycoside and/or a docetaxel monoglycoside, and having an antibody specifically recognizing a cancer cell, the method comprising a step of bringing a liposome encapsulating a polyoxyethylene ester derivative, a lower alcohol, and a buffer or water into contact with a solution in which a paclitaxel monoglycoside and/or a docetaxel monoglycoside is dissolved in an alkylene glycol-containing buffer or water.