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公开(公告)号：US20170280720A1
公开(公告)日：2017-10-05
申请号：US15511514
申请日：2015-09-17
Applicant: EPIZYME, INC.
Inventor： Richard CHESWORTH , Lorna Helen MITCHELL , Gideon SHAPIRO , Oscar Miguel MORADEI , Kevin Wayne KUNTZ , Kenneth W. DUNCAN , Lei JIN
IPC: A01N47/10 , C07D277/20 , C07D233/54 , C07D209/10 , C07D241/02
CPC classification number: A01N47/10 , A61K38/45 , C07D209/10 , C07D233/54 , C07D241/02 , C07D277/20 , C07D471/04 , C07D487/04
Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.
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公开(公告)号：US20240245698A1
公开(公告)日：2024-07-25
申请号：US18606946
申请日：2024-03-15
Applicant: Epizyme, Inc.
Inventor： Kevin W. KUNTZ , Richard CHESWORTH , Kenneth W. DUNCAN , Heike KEILHACK , Natalie WARHOLIC , Christine KLAUS , Sarah K. KNUTSON , Timothy J.N. WIGLE , Masashi SEKI , Syuji SHIROTORI , Satoshi KAWANO
IPC: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20200317643A1
公开(公告)日：2020-10-08
申请号：US16817791
申请日：2020-03-13
Applicant: Epizyme, Inc.
Inventor： Kevin W. KUNTZ , Edward J. OLHAVA , Richard CHESWORTH , Kenneth W. DUNCAN
IPC: C07D401/12 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , A61P35/00 , C07D471/04
Abstract: The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US20180318309A1
公开(公告)日：2018-11-08
申请号：US15816907
申请日：2017-11-17
Applicant: Epizyme, Inc.
Inventor： Kevin W. KUNTZ , Richard CHESWORTH , Kenneth W. DUNCAN , Heike KEILHACK , Natalie WARHOLIC , Christine KLAUS , Sarah K. KNUTSON , Timothy J.N. WIGLE , Masashi SEKI , Syuji SHIROTORI , Satoshi KAWANO
IPC: A61K31/5377 , C07D498/08 , C07D213/64 , A61K31/444 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/553 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , C07D491/107 , C07D491/08 , C07D417/12 , C07D413/12 , C07D409/12 , C07D405/12 , C07D401/12 , C07D405/14
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20160214985A1
公开(公告)日：2016-07-28
申请号：US14654303
申请日：2013-12-20
Applicant: EPIZYME, INC.
Inventor： Kenneth W. DUNCAN , Richard CHESWORTH , Michael John MUNCHHOF , Lei JIN
IPC: C07D487/04 , C07D401/10 , C07D405/12 , C07D471/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D409/12 , C07D217/04 , C07D413/12
CPC classification number: C07D487/04 , C07D217/02 , C07D217/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.
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Patent Agency Ranking
公开(公告)号：US20240277723A1
公开(公告)日：2024-08-22
申请号：US18606903
申请日：2024-03-15
Applicant: Epizyme, Inc.
Inventor： Kevin W. KUNTZ , Richard CHESWORTH , Kenneth W. DUNCAN , Heike KEILHACK , Natalie WARHOLIC , Christine KLAUS , Sarah K. KNUTSON , Timothy J.N. WIGLE , Masashi SEKI , Suji SHIROTORI , Satoshi KAWANO
IPC: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20190300502A1
公开(公告)日：2019-10-03
申请号：US16299722
申请日：2019-03-12
Applicant: Epizyme, Inc.
Inventor： Kevin W. KUNTZ , Edward J. OLHAVA , Richard CHESWORTH , Kenneth W. DUNCAN
IPC: C07D401/12 , A61P35/00 , C07D471/04 , C07D401/04 , C07D405/14 , C07D401/14 , C07D413/14
Abstract: The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US20170252349A1
公开(公告)日：2017-09-07
申请号：US15598078
申请日：2017-05-17
Applicant: Epizyme, Inc.
Inventor： Kevin W. KUNTZ , Richard CHESWORTH , Kenneth W. DUNCAN , Heike KEILHACK , Natalie WARHOLIC , Christine KLAUS , Sarah K. KNUTSON , Timothy J. N. WIGLE , Masashi SEKI , Syuji SHIROTORI , Satoshi KAWANO
IPC: A61K31/5377 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D405/14 , C07D498/08 , A61K31/551 , A61K31/506 , A61K31/496 , A61K31/4709 , A61K31/4545 , A61K31/553 , A61K31/4439 , A61K31/4436 , A61K31/4433 , A61K31/443 , A61K31/4412 , C07D213/64 , A61K31/444
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20240245697A1
公开(公告)日：2024-07-25
申请号：US18606925
申请日：2024-03-15
Applicant: Epizyme, Inc.
Inventor： Kevin W. KUNTZ , Richard CHESWORTH , Kenneth W. DUNCAN , Heike KEILHACK , Natalie WARHOLIC , Christine KLAUS , Sarah K. KNUTSON , Timothy J.N. WIGLE , Masashi SEKI , Syuji SHIROTORI , Satoshi KAWANO
IPC: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20210379076A1
公开(公告)日：2021-12-09
申请号：US17308610
申请日：2021-05-05
Applicant: Epizyme, Inc.
Inventor： Kevin W. KUNTZ , Richard CHESWORTH , Kenneth W. DUNCAN , Heike KEILHACK , Natalie WARHOLIC , Christine KLAUS , Sarah K. KNUTSON , Timothy J. N. WIGLE , Masashi SEKI , Syuji SHIROTORI , Satoshi KAWANO
IPC: A61K31/5377 , C07D498/08 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D213/64 , C07D405/14 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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