公开(公告)号：US20210403597A1

公开(公告)日：2021-12-30

申请号：US17292749

申请日：2019-11-14

申请人： Memorial Sloan Kettering Cancer Center ,  Eureka Therapeutics, Inc.

发明人： David SPRIGGS ,  Javier MORALES ,  Yoko NAKANO ,  Hong LIU

IPC分类号： C07K16/30 ,  A61P35/00

摘要： Provided herein are compositions, methods, and uses involving anti-Mucin-16 (MUC16) agents that immunospecifically bind an epitope of Mucin-16 (MUC16). Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer and diseases associated with positive MUC16 expression.

公开(公告)号：US20210101954A1

公开(公告)日：2021-04-08

申请号：US16608336

申请日：2018-04-24

申请人： EUREKA THERAPEUTICS, INC.

发明人： Lucas HORAN ,  Yiyang XU ,  Zhiyuan YANG ,  Hong LIU ,  Javier MORALES ,  Lianxing LIU

IPC分类号： C07K14/725 ,  C07K16/28 ,  A61P35/00

摘要： The present application provides chimeric antibody-TCR constructs comprising an antigen-binding module that specifically binds to a target antigen and a T cell receptor module capable of recruiting at least one TCR-associated signaling molecule. Also provided are methods of making and using these constructs.

公开(公告)号：US20210107992A1

公开(公告)日：2021-04-15

申请号：US16608377

申请日：2018-04-24

申请人： EUREKA THERAPEUTICS, INC.

发明人： Pengbo ZHANG ,  Yiyang XU ,  Javier MORALES ,  Yoko NAKANO ,  Hong LIU ,  Jingyi XIANG ,  Timothy ACKER

IPC分类号： C07K16/30 ,  C07K14/705 ,  C07K14/725 ,  G01N33/574 ,  C07K16/28 ,  A61P35/00

摘要： The present application provides constructs comprising an antibody moiety specifically recognizing Glypican 3 (GPC3), such as a cell surface-bound GPC3. Also provided are methods of making and using these constructs.