公开(公告)号：US20220185910A1

公开(公告)日：2022-06-16

申请号：US17253589

申请日：2019-06-17

申请人： EUREKA THERAPEUTICS, INC.

发明人： Hong LIU ,  Hongruo YUN ,  Xiaomei GE ,  Zhiyuan YANG ,  Lianxing LIU ,  Pengbo ZHANG ,  Yixiang XU ,  Shan LI ,  Lucas HORAN

IPC分类号： C07K16/30 ,  C07K14/725 ,  C07K14/705 ,  G01N33/574 ,  C07K16/28 ,  A61P35/00

摘要： The present application provides constructs comprising an antibody moiety that specifically binds to PSMA (e.g., PSMA expressed on the surface of a cell). Also provided are methods of making and using these constructs.

公开(公告)号：US20240317855A1

公开(公告)日：2024-09-26

申请号：US18593621

申请日：2024-03-01

申请人： EUREKA THERAPEUTICS, INC.

发明人： Hong LIU ,  Pengbo ZHANG ,  Lucas HORAN ,  Yiyang XU ,  Binnaz K. STALEY ,  Lianxing LIU ,  Hongruo YUN

IPC分类号： C07K16/28 ,  A61K35/17 ,  A61K38/00 ,  A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/30

CPC分类号： C07K16/2803 ,  A61K35/17 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70578 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/283 ,  C07K16/2833 ,  C07K16/2887 ,  C07K16/303 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/522 ,  C07K2317/53 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33

摘要： The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.

公开(公告)号：US20210107992A1

公开(公告)日：2021-04-15

申请号：US16608377

申请日：2018-04-24

申请人： EUREKA THERAPEUTICS, INC.

发明人： Pengbo ZHANG ,  Yiyang XU ,  Javier MORALES ,  Yoko NAKANO ,  Hong LIU ,  Jingyi XIANG ,  Timothy ACKER

IPC分类号： C07K16/30 ,  C07K14/705 ,  C07K14/725 ,  G01N33/574 ,  C07K16/28 ,  A61P35/00

摘要： The present application provides constructs comprising an antibody moiety specifically recognizing Glypican 3 (GPC3), such as a cell surface-bound GPC3. Also provided are methods of making and using these constructs.

公开(公告)号：US20210107976A1

公开(公告)日：2021-04-15

申请号：US16608366

申请日：2018-04-24

申请人： EUREKA THERAPEUTICS, INC.

发明人： Hong LIU ,  Pengbo ZHANG ,  Lucas HORAN ,  Yiyang XU ,  Binnaz K. STALEY ,  Lianxing LIU ,  Hongruo YUN

IPC分类号： C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  C07K16/30 ,  A61K35/17 ,  A61P35/00

摘要： The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.

公开(公告)号：US20230048360A1

公开(公告)日：2023-02-16

申请号：US17817308

申请日：2022-08-03

申请人： Eureka Therapeutics, Inc.

发明人： Pengbo ZHANG ,  Yiyang Xu ,  Javier Morales ,  Yoko Nakano ,  Hong Liu ,  Jingyi Xiang ,  Timothy Acker

IPC分类号： C07K16/30 ,  A61P35/00 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  G01N33/574

摘要： The present application provides constructs comprising an antibody moiety specifically recognizing Glypican 3 (GPC3), such as a cell surface-bound GPC3. Also provided are methods of making and using these constructs.

公开(公告)号：US20200115448A1

公开(公告)日：2020-04-16

申请号：US16660515

申请日：2019-10-22

申请人： EUREKA THERAPEUTICS, INC.

发明人： Hong LIU ,  Pengbo ZHANG ,  Lucas HORAN ,  Yiyang XU ,  Binnaz K. STALEY ,  Lianxing LIU ,  Hongruo YUN

IPC分类号： C07K16/28 ,  C07K14/725 ,  C07K16/30 ,  A61K35/17 ,  A61P35/00 ,  C07K14/705

摘要： The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.