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公开(公告)号：US20190315859A1
公开(公告)日：2019-10-17
申请号：US16388508
申请日：2019-04-18
发明人： HONG LIU , Jingwei Lu , Zhiyuan Yang , Li Long , Neal Cheng
IPC分类号： C07K16/28 , C12N5/0783 , C07K16/30 , C07K14/725 , A61K35/17 , C07K14/705 , A61P35/00
摘要： Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by CD 19 expression, in particular, B cell lymphomas and leukemias.
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公开(公告)号：US10301388B2
公开(公告)日：2019-05-28
申请号：US15840870
申请日：2017-12-13
发明人： Hong Liu , Jingwei Lu , Zhiyuan Yang , Li Long , Neal Cheng
IPC分类号： C07K16/28 , A61K35/17 , C12N5/0783 , A61P35/00 , C07K14/725 , C07K14/705 , C07K16/30 , A61K39/00 , A61K38/00
摘要： Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by CD 19 expression, in particular, B cell lymphomas and leukemias.
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公开(公告)号：US10011658B2
公开(公告)日：2018-07-03
申请号：US15829783
申请日：2017-12-01
发明人： Cheng Liu , Hong Liu , Yiyang Xu , Jingyi Xiang , Li Long
IPC分类号： A61K48/00 , C07K16/18 , C07K16/28 , C12N5/0783 , C12N5/10 , C07K16/30 , C07K14/705 , C07K14/725 , A61K39/00 , A61K38/00
CPC分类号： C07K16/2809 , A61K38/00 , A61K39/00 , A61K39/395 , A61K2039/54 , C07K14/7051 , C07K14/70596 , C07K16/18 , C07K16/2833 , C07K16/303 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/734 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/03
摘要： The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising an AFP peptide and an MHC class I protein. Also provided are methods of making and using these constructs.
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公开(公告)号：US11981742B2
公开(公告)日：2024-05-14
申请号：US16388508
申请日：2019-04-18
发明人： Hong Liu , Jingwei Lu , Zhiyuan Yang , Li Long , Neal Cheng
IPC分类号： C07K16/28 , A61K35/17 , A61K39/00 , A61P35/00 , C07K14/725 , C07K16/30 , C12N5/0783 , A61K38/00 , C07K14/705
CPC分类号： C07K16/2896 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K16/2803 , C07K16/3061 , C12N5/0638 , A61K38/00 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , C07K14/70521 , C07K16/2809 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/02 , C07K2319/03 , C12N2501/599 , C12N2510/00
摘要： Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by CD 19 expression, in particular, B cell lymphomas and leukemias.
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公开(公告)号：US20180134787A1
公开(公告)日：2018-05-17
申请号：US15840870
申请日：2017-12-13
发明人： HONG LIU , Jingwei Lu , Zhiyuan Yang , Li Long , Neal Cheng
IPC分类号： C07K16/28 , A61K35/17 , C07K14/725 , C07K14/705 , A61P35/00 , C07K16/30
CPC分类号： C07K16/2803 , A61K35/17 , A61K38/00 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , A61P35/00 , C07K14/7051 , C07K14/70521 , C07K16/2809 , C07K16/3061 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/02 , C07K2319/03 , C12N5/0638 , C12N2501/599 , C12N2510/00
摘要： Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by CD 19 expression, in particular, B cell lymphomas and leukemias.
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