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公开(公告)号：US11613573B2
公开(公告)日：2023-03-28
申请号：US16608336
申请日：2018-04-24
发明人： Lucas Horan , Yiyang Xu , Zhiyuan Yang , Hong Liu , Javier Morales , Lianxing Liu
IPC分类号： A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C07K16/28 , C07K16/30 , A61K38/00 , A61K39/00
摘要： The present application provides chimeric antibody-TCR constructs comprising an antigen-binding module that specifically binds to a target antigen and a T cell receptor module capable of recruiting at least one TCR-associated signaling molecule. Also provided are methods of making and using these constructs.
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公开(公告)号：US11993661B2
公开(公告)日：2024-05-28
申请号：US17253589
申请日：2019-06-17
发明人： Hong Liu , Hongruo Yun , Xiaomei Ge , Zhiyuan Yang , Lianxing Liu , Pengbo Zhang , Yixiang Xu , Shan Li , Lucas Horan
IPC分类号： C07K16/00 , A61P35/00 , C07H21/04 , C07K14/705 , C07K14/725 , C07K16/28 , C07K16/30 , C07K16/46 , C12N5/02 , C12N15/00 , G01N33/574
CPC分类号： C07K16/3069 , A61P35/00 , C07K14/7051 , C07K14/70521 , C07K16/2809 , G01N33/57434 , C07K2317/21 , C07K2317/31 , C07K2317/622 , C07K2319/02 , C07K2319/03
摘要： The present application provides constructs comprising an antibody moiety that specifically binds to PSMA (e.g., PSMA expressed on the surface of a cell). Also provided are methods of making and using these constructs.
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公开(公告)号：US20190315859A1
公开(公告)日：2019-10-17
申请号：US16388508
申请日：2019-04-18
发明人： HONG LIU , Jingwei Lu , Zhiyuan Yang , Li Long , Neal Cheng
IPC分类号： C07K16/28 , C12N5/0783 , C07K16/30 , C07K14/725 , A61K35/17 , C07K14/705 , A61P35/00
摘要： Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by CD 19 expression, in particular, B cell lymphomas and leukemias.
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公开(公告)号：US10301388B2
公开(公告)日：2019-05-28
申请号：US15840870
申请日：2017-12-13
发明人： Hong Liu , Jingwei Lu , Zhiyuan Yang , Li Long , Neal Cheng
IPC分类号： C07K16/28 , A61K35/17 , C12N5/0783 , A61P35/00 , C07K14/725 , C07K14/705 , C07K16/30 , A61K39/00 , A61K38/00
摘要： Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by CD 19 expression, in particular, B cell lymphomas and leukemias.
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公开(公告)号：US10098951B2
公开(公告)日：2018-10-16
申请号：US15829793
申请日：2017-12-01
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： C07K16/00 , A61K39/395 , A61K35/17 , C12N15/62 , C07K14/725 , C07K16/28 , A61K38/00 , A61K39/00
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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公开(公告)号：US11976105B2
公开(公告)日：2024-05-07
申请号：US17181913
申请日：2021-02-22
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： C07K14/725 , A61K35/17 , A61K38/00 , A61K39/00 , A61K39/395 , A61P35/00 , C07K16/28 , C12N15/62
CPC分类号： C07K14/7051 , A61K35/17 , A61K38/00 , A61K39/39558 , A61P35/00 , C07K16/2809 , C07K16/2833 , C12N15/62 , A61K2039/505 , C07K16/2803 , C07K2317/51 , C07K2317/515 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/33 , C07K2319/74
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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公开(公告)号：US20230293687A1
公开(公告)日：2023-09-21
申请号：US18017628
申请日：2021-07-29
发明人： Cheng Liu , Hongbing Zhang , Zhiyuan Yang , Pengbo Zhang , Yixiang Xu , Guangyuan Xiong , Ziyou Cui
IPC分类号： A61K39/00 , C12N15/86 , C07K14/725 , C07K14/705 , C07K16/28 , C07K14/47 , C07K14/005 , C07K16/30 , C07K16/08 , C07K16/18 , C07K14/435 , C07K16/32 , C07K16/40 , C07K14/78 , C07K14/82 , C07K16/44 , C07K14/71 , C07K14/73 , C07K14/735 , A61P35/00
CPC分类号： A61K39/4622 , C12N15/86 , C07K14/7051 , C07K14/70578 , A61K39/4632 , A61K39/464417 , C07K14/70521 , C07K14/70553 , C07K14/70507 , C07K14/70503 , C07K14/7056 , C07K14/705 , A61K39/464411 , A61K39/464402 , A61K39/4644 , A61K39/4633 , C07K16/28 , C07K14/4748 , C07K14/005 , A61K39/464489 , A61K39/464481 , A61K39/464453 , A61K39/464414 , A61K39/464406 , C07K16/3038 , C07K16/303 , C07K16/30 , C07K16/2833 , C07K16/084 , A61K39/464838 , C07K16/18 , A61K39/4643 , C07K14/435 , C07K16/3069 , A61K39/464494 , C07K16/32 , C07K16/40 , C07K14/78 , A61K39/464454 , A61K39/464462 , C07K16/3053 , C07K14/70596 , C07K16/2896 , A61K39/46432 , A61K39/464488 , A61K39/464486 , A61K39/464449 , A61K39/464451 , C07K14/4746 , C07K16/3015 , C07K14/82 , C07K16/44 , A61K39/4645 , C07K14/4727 , C07K16/3092 , C07K14/71 , C07K16/2863 , A61K39/464431 , A61K39/464495 , A61K39/46441 , C07K14/70589 , A61K39/464413 , C07K14/70514 , C07K14/70535 , C07K14/70532 , A61K39/4611 , A61K39/4613 , A61P35/00 , C12N2740/15043 , C07K2319/03 , C07K2319/033 , C07K2319/035 , C07K2317/569 , C07K2317/31 , C07K2317/622 , C07K2317/565
摘要： Described herein are immune cells comprising: a T-cell receptor (TCR) and a chimeric stimulating receptor (CSR) that comprises (i) a ligand-binding module that is capable of binding or interacting with a target ligand; (ii) a transmembrane domain; and (iii) a CD30 costimulatory domain, in which the CSR in the immune cells lacks a functional primary signaling domain. Also provided herein are methods of using the same or components thereof (e.g., the CSR) for therapeutic treatment of cancers (e.g., solid tumor cancers).
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公开(公告)号：US10464988B2
公开(公告)日：2019-11-05
申请号：US16121475
申请日：2018-09-04
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： A61K35/17 , C07K14/725 , C12N15/62 , A61K38/00 , A61K39/395 , C07K16/28 , A61K39/00
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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公开(公告)号：US11981742B2
公开(公告)日：2024-05-14
申请号：US16388508
申请日：2019-04-18
发明人： Hong Liu , Jingwei Lu , Zhiyuan Yang , Li Long , Neal Cheng
IPC分类号： C07K16/28 , A61K35/17 , A61K39/00 , A61P35/00 , C07K14/725 , C07K16/30 , C12N5/0783 , A61K38/00 , C07K14/705
CPC分类号： C07K16/2896 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K16/2803 , C07K16/3061 , C12N5/0638 , A61K38/00 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , C07K14/70521 , C07K16/2809 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/02 , C07K2319/03 , C12N2501/599 , C12N2510/00
摘要： Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by CD 19 expression, in particular, B cell lymphomas and leukemias.
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公开(公告)号：US11421013B2
公开(公告)日：2022-08-23
申请号：US15769724
申请日：2016-10-21
发明人： Jingwei Lu , Zhiyuan Yang , Cheng Liu , Hong Liu , Yiyang Xu , Su Yan , Vivien Wai-Fan Chan , Lucas Horan
IPC分类号： C07K14/725 , A61K35/17 , C12N15/62 , A61K38/00 , A61P35/00 , A61K39/395 , C07K16/28 , A61K39/00
摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
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