公开(公告)号：US10463645B2

公开(公告)日：2019-11-05

申请号：US15593910

申请日：2017-05-12

申请人： EVERFRONT BIOTECH INC.

发明人： Hong-Lin Su ,  Shinn-Zong Lin ,  Horng-Jyh Harn ,  Tzyy-Wen Chiou ,  Hong-Meng Chuang

IPC分类号： A61K31/34 ,  A61K31/19 ,  A61K31/365 ,  A61K31/192

摘要： The present invention relates to a method of delaying the onset of pulmonary fibrosis or treating pulmonary fibrosis, comprising administering to a subject in need an effective amount of an active ingredient selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound of formula (I), and combinations thereof: wherein, A is a C5 alkyl or alkenyl optionally substituted with —OH or ═O; X is H or OH; Y is O; and R1 is H or absent, with the proviso that, when R1 is absent, Y and A bind together to form a five-membered ring.

公开(公告)号：US10688128B2

公开(公告)日：2020-06-23

申请号：US15596858

申请日：2017-05-16

申请人： EVERFRONT BIOTECH INC.

发明人： Hong-Lin Su ,  Shinn-Zong Lin ,  Horng-Jyh Harn ,  Tzyy-Wen Chiou ,  Sheng-Feng Tsai

IPC分类号： A61K9/08 ,  A61K31/365 ,  A61K35/15 ,  A61P35/00 ,  A61K9/70 ,  A61K9/00

摘要： A method for at least one of activating autoimmune system and treating cancer is provided. The method comprises administering to a subject in need an effective amount of Z-butylidenephthalide and an effective amount of mononuclear cells.

公开(公告)号：US10682335B2

公开(公告)日：2020-06-16

申请号：US15329051

申请日：2014-07-28

申请人： EVERFRONT BIOTECH INC.

发明人： Hong-Lin Su ,  Chia-Yu Chang ,  Shiaw-Min Hwang ,  Huai-En Lu ,  Horng-Jyh Harn ,  Shinn-Zong Lin ,  Ping-Shan Lai

IPC分类号： A61K31/365 ,  A61K8/49 ,  A61K9/00 ,  A61K36/23 ,  A61K36/28 ,  A61Q7/00

摘要： The present invention discloses use of butylidenephthalide (Bdph), a method of using the same, and a method for preparing a pharmaceutical composition containing the same. Because Bdph has the capability of promoting the hair growth and reducing the β-amyloid protein (Aβ) level in nerve cells, the efficacy of improving the health and appearance of a subject can be achieved by administrating an effective amount of Bdph to the subject. Specifically, the Bdph has the efficacy of preventing or treating neurodegenerative diseases such as Alzheimer's disease caused by excessive build up of Aβ in the cells, and as an active ingredient in a topical composition, the Bdph is effective in promoting the hair growth at the site where the Bdph is administered. Furthermore, the method for preparing a pharmaceutical composition containing Bdph comprises preparing the pharmaceutical composition through an organic synthesis reaction, wherein the Bdph is coated with a polymeric material such as F127 by covalent bonding of the polymeric material with the Bdph, thereby achieving the effect of reducing the cytotoxicity of the pharmaceutical composition for an organism.