公开(公告)号：US20180311208A1

公开(公告)日：2018-11-01

申请号：US16025764

申请日：2018-07-02

申请人： EVERFRONT BIOTECH INC.

发明人： Horng-Jyh HARN ,  Tzyy-Wen Chiou ,  Shinn-Zong Lin ,  Ssu-Yin Yen

IPC分类号： A61K31/365 ,  A61P35/02

摘要： A method for decreasing the incidence rate and/or recurrent rate of cancer is provided. The method comprises administering to a subject in need an effective amount of butylidenephthalide (BP).

公开(公告)号：US09504751B2

公开(公告)日：2016-11-29

申请号：US14695088

申请日：2015-04-24

申请人： EVERFRONT BIOTECH INC.

发明人： Tzyy-Wen Chiou ,  Horng-Jyh Harn ,  Shinn-Zong Lin ,  Yu-Han Chiu

IPC分类号： A61K31/365 ,  A61K47/44 ,  A61K31/343 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K9/00 ,  A61K9/107

CPC分类号： A61K47/44 ,  A61K9/0043 ,  A61K9/107 ,  A61K9/1075 ,  A61K31/343 ,  A61K31/365 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20

摘要： A pharmaceutical composition comprising: (a) a medium system, comprising a first component, a second component and a third component, wherein the first component is a phosphate buffered saline, the second component is selected from the group consisting of vegetable oils, animal oils, fatty acids and combinations thereof, and the third component is selected from the group consisting of polyethylene glycol, dimethyl sulfoxide (DMSO), ethanol, polypropylene glycol, polysorbate, polyoxyethylated vegetable oil, ethyl acetate, 2-hydroxyethyl 12-hydroxyoctadecanoate, tocopheryl polyethylene glycol succinate and combinations thereof; and (b) n-butylidenephthalide (BP).

公开(公告)号：US10463645B2

公开(公告)日：2019-11-05

申请号：US15593910

申请日：2017-05-12

申请人： EVERFRONT BIOTECH INC.

发明人： Hong-Lin Su ,  Shinn-Zong Lin ,  Horng-Jyh Harn ,  Tzyy-Wen Chiou ,  Hong-Meng Chuang

IPC分类号： A61K31/34 ,  A61K31/19 ,  A61K31/365 ,  A61K31/192

摘要： The present invention relates to a method of delaying the onset of pulmonary fibrosis or treating pulmonary fibrosis, comprising administering to a subject in need an effective amount of an active ingredient selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound of formula (I), and combinations thereof: wherein, A is a C5 alkyl or alkenyl optionally substituted with —OH or ═O; X is H or OH; Y is O; and R1 is H or absent, with the proviso that, when R1 is absent, Y and A bind together to form a five-membered ring.

公开(公告)号：US10688128B2

公开(公告)日：2020-06-23

申请号：US15596858

申请日：2017-05-16

申请人： EVERFRONT BIOTECH INC.

发明人： Hong-Lin Su ,  Shinn-Zong Lin ,  Horng-Jyh Harn ,  Tzyy-Wen Chiou ,  Sheng-Feng Tsai

IPC分类号： A61K9/08 ,  A61K31/365 ,  A61K35/15 ,  A61P35/00 ,  A61K9/70 ,  A61K9/00

摘要： A method for at least one of activating autoimmune system and treating cancer is provided. The method comprises administering to a subject in need an effective amount of Z-butylidenephthalide and an effective amount of mononuclear cells.

公开(公告)号：US10987339B2

公开(公告)日：2021-04-27

申请号：US16025764

申请日：2018-07-02

申请人： EVERFRONT BIOTECH INC.

发明人： Horng-Jyh Harn ,  Tzyy-Wen Chiou ,  Shinn-Zong Lin ,  Ssu-Yin Yen

IPC分类号： A61K31/365 ,  A23L33/10 ,  A61P35/02

摘要： A method for decreasing the incidence rate and/or recurrent rate of cancer is provided. The method comprises administering to a subject in need an effective amount of butylidenephthalide (BP).

公开(公告)号：US09889117B2

公开(公告)日：2018-02-13

申请号：US14504180

申请日：2014-10-01

申请人： EVERFRONT BIOTECH INC.

发明人： Shinn-Zong Lin ,  Horng-Jyh Harn ,  Tzyy-Wen Chiou ,  Cheng-Han Wu ,  Ssu-Yin Yen

IPC分类号： A61K31/365

CPC分类号： A61K31/365

摘要： A method for treating and/or delaying the degeneration of Purkinje cells in a subject is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a medicament, wherein the medicament comprises a phthalide selected from the group consisting of n-butylidenephthalide (BP), a metabolic precursor of BP, a pharmaceutically acceptable salt of a metabolic precursor of BP, a pharmaceutically acceptable ester of a metabolic precursor of BP, and combinations thereof.