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1.发明申请COMPOSITION OF THE TREATMENT OF VASCULAR DISEASES OR KCa3.1 CHANNEL-MEDIATED DISEASES COMPRISING MODAFINIL OR DERIVATIVES THEREOF 有权治疗血管疾病或KCa3.1通道介导性疾病的组合物，其包含其中的衍生物或衍生物公开(公告)号：US20140296333A1
公开(公告)日：2014-10-02
申请号：US14354332
申请日：2012-10-24
Inventor： Suk Hyo Suh , Jae Chul Jung , Sei Kwan Oh
IPC: A61K31/341 , A23L1/30 , A61K31/165
CPC classification number: A61K31/341 , A23L33/10 , A23V2002/00 , A61K31/165 , A61K31/34 , C07D307/14 , A23V2200/326
Abstract: The present invention relates to modafinil or derivatives thereof as a medicine for the treatment of vascular diseases or KCa3.1 channel (Ca activated K channel) mediated diseases and a novel use of the same. More specifically, the present invention relates to a pharmaceutical composition for the prevention or treatment of vascular diseases or KCa3.1 channel-mediated diseases comprising modafinil or a derivative of modafinil, or pharmaceutically acceptable salts thereof which relax blood vessels and inhibit KCa3.1 channel currents by increasing intracellular cAMP, a method for treating vascular diseases or KCa3.1 channel-mediated diseases using the composition and a health functional food composition for the prevention or improvement of vascular diseases or the KCa3.1 channel-mediated diseases comprising modafinil or a modafinil derivative compound, or sitologically acceptable salts thereof.
Abstract translation: 本发明涉及莫达非尼或其衍生物作为治疗血管疾病或KCa3.1通道（Ca激活的K通道）介导的疾病的药物及其新用途。 更具体地，本发明涉及用于预防或治疗血管疾病或KCa3.1通道介导的疾病的药物组合物，其包含莫达非尼或莫达非尼的衍生物或其药学上可接受的盐，其放松血管并抑制KCa3.1通道 通过增加细胞内cAMP，使用该组合物治疗血管疾病或KCa3.1通道介导的疾病的方法，以及用于预防或改善血管疾病或KCa3.1通道介导的疾病的健康功能食品组合物，其包含莫达非尼或 莫达非尼衍生物化合物或其可以使用的盐。
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2.发明授权Composition of the treatment of vascular diseases or KCa3.1 channel-mediated diseases comprising modafinil or derivatives thereof 有权治疗血管疾病或KCa3.1通道介导的疾病的组合物，其包含莫达非尼或其衍生物公开(公告)号：US09259412B2
公开(公告)日：2016-02-16
申请号：US14354332
申请日：2012-10-24
Inventor： Suk Hyo Suh , Jae Chul Jung , Sei Kwan Oh
IPC: A61K31/34 , C07D307/14 , C07D307/52 , A61K31/341 , A61K31/165 , A23L1/30
CPC classification number: A61K31/341 , A23L33/10 , A23V2002/00 , A61K31/165 , A61K31/34 , C07D307/14 , A23V2200/326
Abstract: The present invention relates to modafinil or derivatives thereof as a medicine for the treatment of vascular diseases or KCa3.1 channel (Ca activated K channel) mediated diseases and a novel use of the same. More specifically, the present invention relates to a pharmaceutical composition for the prevention or treatment of vascular diseases or KCa3.1 channel-mediated diseases comprising modafinil or a derivative of modafinil, or pharmaceutically acceptable salts thereof which relax blood vessels and inhibit KCa3.1 channel currents by increasing intracellular cAMP, a method for treating vascular diseases or KCa3.1 channel-mediated diseases using the composition and a health functional food composition for the prevention or improvement of vascular diseases or the KCa3.1 channel-mediated diseases comprising modafinil or a modafinil derivative compound, or sitologically acceptable salts thereof.
Abstract translation: 本发明涉及莫达非尼或其衍生物作为治疗血管疾病或KCa3.1通道（Ca激活的K通道）介导的疾病的药物及其新用途。 更具体地，本发明涉及用于预防或治疗血管疾病或KCa3.1通道介导的疾病的药物组合物，其包含莫达非尼或莫达非尼的衍生物或其药学上可接受的盐，其放松血管并抑制KCa3.1通道 通过增加细胞内cAMP，使用该组合物治疗血管疾病或KCa3.1通道介导的疾病的方法，以及用于预防或改善血管疾病或KCa3.1通道介导的疾病的健康功能食品组合物，其包含莫达非尼或 莫达非尼衍生物化合物或其可以使用的盐。
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