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1.发明申请ANTISENSE OLIGONUCLEOTIDES DIRECTED AGAINST CONNECTIVE TISSUE GROWTH FACTOR AND USES THEREOF 有权针对连接组织生长因子的抗原寡核苷酸及其用途公开(公告)号：US20150376623A1
公开(公告)日：2015-12-31
申请号：US14753860
申请日：2015-06-29
IPC分类号： C12N15/113
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
摘要翻译： 本发明提供了包含能够抑制表达结缔组织因子的修饰寡核苷酸和含有其的组合物的化合物，以及治疗过度放射性疾病和纤维化疾病的方法，以及使用这些化合物减少伤口愈合引起的瘢痕形成。
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2.发明申请公开(公告)号：US20190323013A1
公开(公告)日：2019-10-24
申请号：US16204866
申请日：2018-11-29
IPC分类号： C12N15/113
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
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3.发明申请公开(公告)号：US20170335329A1
公开(公告)日：2017-11-23
申请号：US15602955
申请日：2017-05-23
IPC分类号： C12N15/113
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
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4.发明授权公开(公告)号：US09688987B2
公开(公告)日：2017-06-27
申请号：US14753860
申请日：2015-06-29
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , C12N5/00
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
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公开(公告)号：US20150291960A1
公开(公告)日：2015-10-15
申请号：US14542923
申请日：2014-11-17
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing CD40. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to CD40 include hyperproliferative disorders, graft versus host disease (GVHD), graft rejection, asthma, airway hyperresponsiveness, chronic obstructive pulmonary disease (COPD), multiple sclerosis (MS), systemic lupus erythematosus (SLE), and certain forms of arthritis.
摘要翻译： 本文公开了用于减少CD40的反义化合物和方法。 通过施用靶向CD40的反义化合物可以改善的疾病状况的实例包括过度增殖性疾病，移植物抗宿主病（GVHD），移植物排斥反应，哮喘，气道高反应性，慢性阻塞性肺疾病（COPD），多发性硬化（MS） ，系统性红斑狼疮（SLE）和某些形式的关节炎。
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公开(公告)号：US09273315B2
公开(公告)日：2016-03-01
申请号：US14528656
申请日：2014-10-30
发明人： Gene Hung , C. Frank Bennett , Susan M. Freier , Holly Kordasiewicz , Lisa Stanek , Don W. Cleveland , Seng H. Cheng , Lamya Shihabuddin
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods, compounds, and compositions for reducing expression of huntingtin mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate Huntington's disease, or a symptom thereof.
摘要翻译： 本文提供了用于降低动物中亨廷丁蛋白mRNA和蛋白质表达的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善亨廷顿病或其症状。
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公开(公告)号：US20160024496A1
公开(公告)日：2016-01-28
申请号：US14436039
申请日：2013-10-15
发明人： C. Frank Bennett , Susan M. Freier , Jeffrey D. Rothstein , Christopher Donnelly , Rita G. Sattler
IPC分类号： C12N15/113 , A61K31/7088
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/111 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12N2310/3521
摘要： Disclosed herein are methods for monitoring expression of C9ORF72 mRNA and protein in an animal with C9ORF72 specific inhibitors. Such C9ORF72 specific inhibitors include antisense compounds.
摘要翻译： 本文公开了用C9ORF72特异性抑制剂监测动物中C9ORF72 mRNA和蛋白质的表达的方法。 这种C9ORF72特异性抑制剂包括反义化合物。
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公开(公告)号：US20150167008A1
公开(公告)日：2015-06-18
申请号：US14630581
申请日：2015-02-24
发明人： C. Frank Bennett , Kenneth W. Dobie
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y115/01001 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节超氧化物歧化酶1的表达，可溶性。 组合物包含靶向编码超氧化物歧化酶1的核酸的可反应化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节超氧化物歧化酶1，可溶性表达和治疗与超氧化物歧化酶1表达相关的疾病的方法。
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公开(公告)号：US09057066B2
公开(公告)日：2015-06-16
申请号：US13708839
申请日：2012-12-07
发明人： Gene Hung , Janet M. Leeds , C. Frank Bennett , Susan M. Freier
IPC分类号： C07H21/02 , A01N43/04 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/31 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/33 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's disease progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntingtin's disease in an individual susceptible to Huntingtin's Disease. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译： 本文公开了用于调节细胞，组织或动物中亨廷丁氏蛋白的表达的化合物，组合物和方法。 还提供了使用靶向亨廷顿汀的反义化合物减慢或预防亨廷顿病进展的方法。 另外提供的方法是延缓或预防在亨廷顿病易感的个体中亨廷顿病发病的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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10.发明申请COMPOUNDS AND METHODS FOR IMPROVED CELLULAR UPTAKE OF ANTISENSE COMPOUNDS 审中-公开用于改进抗细胞化合物细胞摄取的化合物和方法公开(公告)号：US20150322428A1
公开(公告)日：2015-11-12
申请号：US14409332
申请日：2013-06-18
发明人： Erich Koller , C. Frank Bennett
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2320/31 , C12N2320/32 , C12N2320/50
摘要： The present invention provides method of increasing the efficacy and potency of antisense compounds. In certain embodiments, the invention provides methods for improved cellular uptake. In certain embodiments, the resulting antisense activity is greater at a particular concentration of antisense compound than the antisense activity at the same concentration of the antisense compound in the absence of the ESCRT modulator.
摘要翻译： 本发明提供了提高反义化合物的功效和效力的方法。 在某些实施方案中，本发明提供了改善细胞摄取的方法。 在某些实施方案中，在不存在ESCRT调节剂的反义化合物相同浓度的反义化合物的反应化合物的特定浓度下，所得到的反义活性更大。
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