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公开(公告)号：US20100120840A1
公开(公告)日：2010-05-13
申请号：US11989272
申请日：2006-07-28
申请人： Edward Boyd , Frederick Brookfield , Jonathan Gridley , Konrad Honold , Raymond Lau , Stefan Scheiblich
发明人： Edward Boyd , Frederick Brookfield , Jonathan Gridley , Konrad Honold , Raymond Lau , Stefan Scheiblich
IPC分类号： A61K31/437 , C07D471/04 , A61P35/00 , A61P37/02
CPC分类号： C07D471/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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2.发明授权公开(公告)号：US07776878B2
公开(公告)日：2010-08-17
申请号：US11989272
申请日：2006-07-28
申请人： Edward Boyd , Frederick Brookfield , Jonathan Gridley , Konrad Honold , Raymond Lau , Stefan Scheiblich
发明人： Edward Boyd , Frederick Brookfield , Jonathan Gridley , Konrad Honold , Raymond Lau , Stefan Scheiblich
CPC分类号： C07D471/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备方法以及上述用途 用于控制或预防癌症等疾病的化合物。
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公开(公告)号：US07226923B2
公开(公告)日：2007-06-05
申请号：US11233311
申请日：2005-09-23
申请人： Edward Boyd , Frederick Brookfield , Guy Georges , Bernhard Goller , Sabine Huensch , Petra Rueger , Matthias Rueth , Stefan Scheiblich , Christine Schuell , Wolfgang von der Saal , Justin Warne , Stefan Weigand
发明人： Edward Boyd , Frederick Brookfield , Guy Georges , Bernhard Goller , Sabine Huensch , Petra Rueger , Matthias Rueth , Stefan Scheiblich , Christine Schuell , Wolfgang von der Saal , Justin Warne , Stefan Weigand
IPC分类号： C07D403/12 , C07D403/14 , A61K31/502
CPC分类号： C07D403/12
摘要： Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.
摘要翻译： 公开了式I化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体。 还公开了制备上述化合物的方法，含有它们的药物组合物，以及上述化合物在治疗，控制或预防诸如癌症等疾病中的用途。
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公开(公告)号：US20060089359A1
公开(公告)日：2006-04-27
申请号：US11233311
申请日：2005-09-23
申请人： Edward Boyd , Frederick Brookfield , Guy Georges , Bernhard Goller , Sabine Huensch , Petra Rueger , Matthias Rueth , Stefan Scheiblich , Christine Schuell , Wolfgang von der Saal , Justin Warne , Stefan Weigand
发明人： Edward Boyd , Frederick Brookfield , Guy Georges , Bernhard Goller , Sabine Huensch , Petra Rueger , Matthias Rueth , Stefan Scheiblich , Christine Schuell , Wolfgang von der Saal , Justin Warne , Stefan Weigand
IPC分类号： A61K31/502 , C07D403/02
CPC分类号： C07D403/12
摘要： Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.
摘要翻译： 公开了式I化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体。 还公开了制备上述化合物的方法，含有它们的药物组合物，以及上述化合物在治疗，控制或预防诸如癌症等疾病中的用途。
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公开(公告)号：US20090318428A1
公开(公告)日：2009-12-24
申请号：US12374682
申请日：2007-09-04
IPC分类号： A61K31/437 , C07D471/04 , A61K31/5377 , A61K31/506 , A61K31/501 , A61K31/517 , A61K31/5415 , A61P35/00
CPC分类号： C07D471/04
摘要： Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式I化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物及其制备，以及上述化合物 控制或预防癌症等疾病。
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![Pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents](/abs-image/US/2007/01/16/US07163941B2/abs.jpg.150x150.jpg)
6.发明授权Pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents 失效吡啶并[2,3-d]嘧啶-7-甲酸衍生物，其制备和用作药剂公开(公告)号：US07163941B2
公开(公告)日：2007-01-16
申请号：US10809067
申请日：2004-03-25
IPC分类号： C07D471/04 , A61K31/495 , C07D239/00
CPC分类号： C07D471/04
摘要： The invention describes compounds of the general formula I a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The compounds show activity as protein kinase inhibitors, in particular src family tyrosine kinase inhibitors, and may therefore be useful for the treatment of diseases mediated by said tyrosine kinases.
摘要翻译： 本发明描述了通式I的化合物，其制备方法，含有它们的药物及其制备以及这些化合物作为药物活性剂的用途。 化合物显示出作为蛋白激酶抑制剂，特别是src家族酪氨酸激酶抑制剂的活性，因此可用于治疗所述酪氨酸激酶介导的疾病。
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公开(公告)号：US20060014765A1
公开(公告)日：2006-01-19
申请号：US11079623
申请日：2005-03-14
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04
摘要： The invention describes compounds of the general formula I a process for their manufacture, compositions containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. These compounds show activity as protein kinase inhibitors, in particular src family tyrosine kinase inhibitors, and may therefore be useful for the treatment of diseases mediated by said tyrosine kinases.
摘要翻译： 本发明描述了通式I的化合物，其制备方法，含有它们的组合物及其制备方法以及这些化合物作为药物活性剂的用途。 这些化合物显示出作为蛋白激酶抑制剂，特别是src家族酪氨酸激酶抑制剂的活性，因此可用于治疗由所述酪氨酸激酶介导的疾病。
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![Pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents](/abs-image/US/2005/06/16/US20050130984A1/abs.jpg.150x150.jpg)
8.发明申请Pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents 失效吡啶并[2,3-d]嘧啶-7-甲酸衍生物，其制备和用作药剂公开(公告)号：US20050130984A1
公开(公告)日：2005-06-16
申请号：US10809067
申请日：2004-03-25
IPC分类号： A61P35/00 , C07D471/04 , A61K31/519 , C07D487/02
CPC分类号： C07D471/04
摘要： The invention describes compounds of the general formula I a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The compounds show activity as protein kinase inhibitors, in particular src family tyrosine kinase inhibitors, and may therefore be useful for the treatment of diseases mediated by said tyrosine kinases.
摘要翻译： 本发明描述了通式I的化合物，其制备方法，含有它们的药物及其制备以及这些化合物作为药物活性剂的用途。 化合物显示出作为蛋白激酶抑制剂，特别是src家族酪氨酸激酶抑制剂的活性，因此可用于治疗由所述酪氨酸激酶介导的疾病。
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![Amide derivatives of 3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents](/abs-image/US/2010/02/02/US07655651B2/abs.jpg.150x150.jpg)
9.发明授权Amide derivatives of 3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents 失效3-苯基 - 二氢嘧啶并[4,5-d]嘧啶酮的酰胺衍生物，其制造和用作药剂公开(公告)号：US07655651B2
公开(公告)日：2010-02-02
申请号：US11660198
申请日：2005-08-30
申请人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolfgang Schaefer , Stefan Scheiblich , Manfred Schwaiger
发明人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolfgang Schaefer , Stefan Scheiblich , Manfred Schwaiger
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5355 , C07D239/38 , A61P29/00 , A61P35/00 , A61P19/08 , A61P25/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
摘要翻译： 本发明涉及3-苯基二氢嘧啶并[4,5-d]嘧啶酮的新型酰胺衍生物，其制备方法，含有它们的药物及其制备以及这些化合物作为药物活性剂的用途。 本发明的衍生物是通式（I）的新化合物。
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![7H-Pyrido[3,4-D]Pyrimidin-8-Ones, Their Manufacture and Use as Protein Kinase Inhibitors](/abs-image/US/2009/01/29/US20090030020A1/abs.jpg.150x150.jpg)
10.发明申请7H-Pyrido[3,4-D]Pyrimidin-8-Ones, Their Manufacture and Use as Protein Kinase Inhibitors 失效7H-吡啶并[3,4-D]嘧啶-8-酮，其制造和用作蛋白激酶抑制剂公开(公告)号：US20090030020A1
公开(公告)日：2009-01-29
申请号：US12087420
申请日：2007-01-29
申请人： Konrad Honold , Jane Paul , Carl Roeschlaub , Wolfgang Schaefer , Stefan Scheiblich , Thomas Von Hirschheydt , Alan Whittle
发明人： Konrad Honold , Jane Paul , Carl Roeschlaub , Wolfgang Schaefer , Stefan Scheiblich , Thomas Von Hirschheydt , Alan Whittle
IPC分类号： A61K31/519 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04
摘要： Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式I化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在对照或 预防癌症等疾病。
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