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    Polymeric contrast agents for use in medical imaging
    1.
    发明申请
    Polymeric contrast agents for use in medical imaging 审中-公开
    用于医学成像的聚合物造影剂

    公开(公告)号：US20060140869A1

    公开(公告)日：2006-06-29

    申请号：US11022984

    申请日：2004-12-23

    申请人： Egidijus Uzgiris ,  Mohan Amaratunga ,  Brian Grimmond ,  Daniel Meyer ,  Joanne Smith

    发明人： Egidijus Uzgiris ,  Mohan Amaratunga ,  Brian Grimmond ,  Daniel Meyer ,  Joanne Smith

    IPC分类号： A61K49/14

    CPC分类号： A61K49/085 ,  A61K49/146

    摘要： A contrast agent comprising a polypeptide is provided. The polypeptide contains lysine residues and optionally, one or more types of amino acid residues selected from the group consisting of glutamic acid residues and aspartic acid residues, wherein the lysine residues are substituted with a group derived from a steric hindrance molecule; and an image producing entity is present in a range between about 100 units and about 2000 units. Methods for administering the aforementioned contrast agent are also provided.

    摘要翻译： 提供了包含多肽的造影剂。 多肽含有赖氨酸残基和任选的一种或多种选自谷氨酸残基和天冬氨酸残基的氨基酸残基，其中赖氨酸残基被衍生自空间位阻分子的基团取代; 并且图像产生实体存在于大约100单位和大约2000单位之间的范围内。 还提供了施用前述造影剂的方法。

    Conjugated macromolecules
    3.
    发明申请
    Conjugated macromolecules 失效
    共轭大分子

    公开(公告)号：US20070122346A1

    公开(公告)日：2007-05-31

    申请号：US11290684

    申请日：2005-11-30

    申请人： Egidijus Uzgiris ,  Brian Grimmond

    发明人： Egidijus Uzgiris ,  Brian Grimmond

    IPC分类号： C07F5/00 ,  A61K49/10

    CPC分类号： A61K51/065 ,  A61K49/085 ,  A61K49/128 ,  A61K49/143 ,  A61K49/146

    摘要： A method of conjugating a carboxylate-containing molecule to an amine-containing macromolecule to form a substituted macromolecule is provided. The method includes (a) forming a first solution by dissolving a substance comprising at least one macromolecule having free amine groups in an aqueous basic solution; (b) forming a second solution by combining at least one carboxylate-containing molecule with at least one acid acceptor in an aprotic solvent; (c) adding at least one carboxylate activating agent to the second solution to form an activated carboxylate-containing molecule; (d) combining the first solution and second solutions to form a multiphasic solution; and (e) isolating the resultant substituted macromolecule from the mixture. A substituted macromolecule produced by the aforementioned method is also provided. Further provided is a method of enhancing a magnetic resonance image of a subject including administering the carboxylate-containing molecule-substituted macromolecule produced by the aforementioned method.

    摘要翻译： 提供了将含羧酸盐的分子与含胺高分子共轭以形成取代的大分子的方法。 该方法包括（a）通过将含有至少一个具有游离胺基的大分子的物质溶解在碱性水溶液中形成第一溶液; （b）通过将至少一种含羧酸盐的分子与非质子溶剂中的至少一种酸受体组合形成第二溶液; （c）向所述第二溶液中加入至少一种羧酸酯活化剂以形成活化的含羧酸盐的分子; （d）组合第一溶液和第二溶液以形成多相溶液; 和（e）从混合物中分离得到的取代的大分子。 还提供了通过上述方法制备的取代的大分子。 还提供了增强受试者的磁共振图像的方法，包括施用通过上述方法制备的含羧酸盐的分子取代的大分子。

    Polymerization method for the synthesis of polypeptide imaging agents
    4.
    发明申请
    Polymerization method for the synthesis of polypeptide imaging agents 失效
    用于合成多肽成像剂的聚合方法

    公开(公告)号：US20060104908A1

    公开(公告)日：2006-05-18

    申请号：US10987662

    申请日：2004-11-12

    申请人： Brian Grimmond ,  Bahram Moasser ,  Mohan Amaratunga

    发明人： Brian Grimmond ,  Bahram Moasser ,  Mohan Amaratunga

    IPC分类号： A61K49/14 ,  C07K1/02 ,  C07F5/00

    CPC分类号： C07D263/44 ,  A61K49/085 ,  A61K49/146

    摘要： A method for synthesizing extended poly(amino acids) conjugated to imaging agents, such as DTPA, is disclosed. The amino acid is initially conjugated to the imaging agent at the monomer stage, followed by formation of the corresponding N-carboxyanhydride. The method utilizes catalyzed ring opening polymerization of the N-carboxyanhydride of the amino acid-imaging agent monomer allowing the formation of a poly(amino acid) backbone having 100% imaging agent conjugation if desired. However, the present method also permits the degree of conjugation to be controlled by copolymerizing the N-carboxyanhydride of the amino acid-imaging agent monomer with one or more unconjugated monomers, i.e. N-carboxyanhydrides of the same or of other amino acids. Various imaging agents may be employed, and new hybrid random, block, and mixed copolymers may be prepared.

    摘要翻译： 公开了用于合成与显影剂缀合的延伸的聚（氨基酸）的方法，例如DTPA。 氨基酸最初在单体阶段与成像剂缀合，然后形成相应的N-羧酸酐。 该方法利用氨基酸显影剂单体的N-羧酸酐的催化开环聚合，如果需要，允许形成具有100％成像剂共轭的聚（氨基酸）主链。 然而，本方法还允许通过使氨基酸显影剂单体的N-羧酸酐与一种或多种非共轭单体，即相同或其它氨基酸的N-羧酸酐共聚来控制缀合度。 可以使用各种成像剂，并且可以制备新的杂化随机，嵌段和混合共聚物。

    Novel Mixed Ligand Core/Shell Iron Oxide Nanoparticles for Inflammation Imaging
    5.
    发明申请
    Novel Mixed Ligand Core/Shell Iron Oxide Nanoparticles for Inflammation Imaging 审中-公开
    新型混合配体核/壳氧化铁纳米粒子用于炎症成像

    公开(公告)号：US20090226376A1

    公开(公告)日：2009-09-10

    申请号：US12042701

    申请日：2008-03-05

    申请人： Brian Grimmond ,  Brian Christopher Bales ,  Chiaki Treynor

    发明人： Brian Grimmond ,  Brian Christopher Bales ,  Chiaki Treynor

    IPC分类号： A61K49/18

    CPC分类号： A61K49/1836 ,  A61K49/1833 ,  A61K49/186 ,  B82Y5/00

    摘要： A nanostructure includes (1) an inorganic nanoparticle core; (2) a first ligand, having a first chain length, bonded to the inorganic nanoparticle core; the first ligand having a charge; and (3) a second ligand, having a second chain length, bonded to the inorganic nanoparticle core; the second ligand is hydrophilic. The second chain length is longer than the first chain length such that varying a mole percent quantity of the first ligand does not substantially alter a hydrodynamic diameter of the nanostructure. Methods for making these nanostructures and their use in magnetic resonance imaging and management of inflammatory conditions are provided.

    摘要翻译： 纳米结构包括（1）无机纳米颗粒核; （2）具有第一链长度的第一配体键合到无机纳米颗粒核心上; 第一配体具有电荷; 和（3）具有第二链长度的第二配体键合到无机纳米颗粒核心上; 第二配体是亲水的。 第二链长比第一链长长，使得改变第一配体的摩尔百分比量基本上不改变纳米结构的流体动力学直径。 提供了制备这些纳米结构的方法及其在磁共振成像和炎症状态管理中的应用。

    Field emission apparatus
    6.
    发明申请
    Field emission apparatus 审中-公开
    场发射装置

    公开(公告)号：US20070247049A1

    公开(公告)日：2007-10-25

    申请号：US11408888

    申请日：2006-04-24

    申请人： Yun Li ,  Brian Grimmond ,  Hai Lu ,  Pierre Bui ,  Joseph Michael

    发明人： Yun Li ,  Brian Grimmond ,  Hai Lu ,  Pierre Bui ,  Joseph Michael

    IPC分类号： H01J1/00 ,  H01J19/06

    CPC分类号： H01J1/304 ,  B82Y10/00 ,  H01J2201/30469

    摘要： By patterning a catalyst layer in a micrometer scale and growing nanotubes on it, the emission area is formed by many small emitter islands. Each emitter island comprises finite nanotubes in a nominal density. Due to the vast amount of gaps between emitter islands, relatively more nanotubes are exposed to the edge region of the emitter, which effectively increases the average inter-spacing of nanotubes. The field shielding effect is significantly reduced this way.

    摘要翻译： 通过图案化微米尺度的催化剂层并在其上生长纳米管，发射区域由许多小的发射体岛形成。 每个发射岛包括标称密度的有限的纳米管。 由于发射极岛之间存在大量的间隙，相对较多的纳米管暴露于发射极的边缘区域，这有效地增加了纳米管的平均间隔。 通过这种方式显着减少场屏蔽效应。