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公开(公告)号：US20070122346A1
公开(公告)日：2007-05-31
申请号：US11290684
申请日：2005-11-30
申请人： Egidijus Uzgiris , Brian Grimmond
发明人： Egidijus Uzgiris , Brian Grimmond
CPC分类号： A61K51/065 , A61K49/085 , A61K49/128 , A61K49/143 , A61K49/146
摘要： A method of conjugating a carboxylate-containing molecule to an amine-containing macromolecule to form a substituted macromolecule is provided. The method includes (a) forming a first solution by dissolving a substance comprising at least one macromolecule having free amine groups in an aqueous basic solution; (b) forming a second solution by combining at least one carboxylate-containing molecule with at least one acid acceptor in an aprotic solvent; (c) adding at least one carboxylate activating agent to the second solution to form an activated carboxylate-containing molecule; (d) combining the first solution and second solutions to form a multiphasic solution; and (e) isolating the resultant substituted macromolecule from the mixture. A substituted macromolecule produced by the aforementioned method is also provided. Further provided is a method of enhancing a magnetic resonance image of a subject including administering the carboxylate-containing molecule-substituted macromolecule produced by the aforementioned method.
摘要翻译： 提供了将含羧酸盐的分子与含胺高分子共轭以形成取代的大分子的方法。 该方法包括（a）通过将含有至少一个具有游离胺基的大分子的物质溶解在碱性水溶液中形成第一溶液; （b）通过将至少一种含羧酸盐的分子与非质子溶剂中的至少一种酸受体组合形成第二溶液; （c）向所述第二溶液中加入至少一种羧酸酯活化剂以形成活化的含羧酸盐的分子; （d）组合第一溶液和第二溶液以形成多相溶液; 和（e）从混合物中分离得到的取代的大分子。 还提供了通过上述方法制备的取代的大分子。 还提供了增强受试者的磁共振图像的方法，包括施用通过上述方法制备的含羧酸盐的分子取代的大分子。
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公开(公告)号：US20060140870A1
公开(公告)日：2006-06-29
申请号：US11023138
申请日：2004-12-23
IPC分类号： A61K49/14
CPC分类号： A61K49/085 , A61K49/128 , A61K49/146
摘要： A method for measuring tumor response to a cancer therapy is provided. The method comprises the steps of injecting a polymeric contrast agent in a subject; obtaining a series of magnetic resonance image signals of the contrast agent in the tumor for up to about 60 minutes; and determining a slope of the magnetic resonance image signal as a function of time.
摘要翻译： 提供了一种测量癌症治疗的肿瘤反应的方法。 该方法包括在受试者中注射聚合造影剂的步骤; 获得肿瘤中造影剂的一系列磁共振图像信号长达约60分钟; 以及确定作为时间的函数的磁共振图像信号的斜率。
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公开(公告)号：US20060140869A1
公开(公告)日：2006-06-29
申请号：US11022984
申请日：2004-12-23
IPC分类号： A61K49/14
CPC分类号： A61K49/085 , A61K49/146
摘要： A contrast agent comprising a polypeptide is provided. The polypeptide contains lysine residues and optionally, one or more types of amino acid residues selected from the group consisting of glutamic acid residues and aspartic acid residues, wherein the lysine residues are substituted with a group derived from a steric hindrance molecule; and an image producing entity is present in a range between about 100 units and about 2000 units. Methods for administering the aforementioned contrast agent are also provided.
摘要翻译： 提供了包含多肽的造影剂。 多肽含有赖氨酸残基和任选的一种或多种选自谷氨酸残基和天冬氨酸残基的氨基酸残基，其中赖氨酸残基被衍生自空间位阻分子的基团取代; 并且图像产生实体存在于大约100单位和大约2000单位之间的范围内。 还提供了施用前述造影剂的方法。
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公开(公告)号：US20070148094A1
公开(公告)日：2007-06-28
申请号：US11317945
申请日：2005-12-22
申请人： Egidijus Uzgiris , Stephen Lomnes , Anup Sood , Kathleen Bove
发明人： Egidijus Uzgiris , Stephen Lomnes , Anup Sood , Kathleen Bove
IPC分类号： A61K49/10
CPC分类号： A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/085 , A61K49/146
摘要： Provided herein are image-enhancing agents that are useful for managing disease by imaging disease tissue using magnetic resonance imaging techniques, optical imaging techniques, and a combination of magnetic resonance imaging techniques and optical imaging techniques. Also provided are methods of imaging disease tissue and managing disease using the image-enhancing agents.
摘要翻译： 本文提供的图像增强剂可用于通过使用磁共振成像技术，光学成像技术以及磁共振成像技术和光学成像技术的组合对疾病组织进行成像来治疗疾病。 还提供了使用图像增强剂对疾病组织进行成像和管理疾病的方法。
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5.发明申请Contrast agent for combined modality imaging and methods and systems thereof 审中-公开组合形态成像的对比剂及其方法和系统公开(公告)号：US20050255044A1
公开(公告)日：2005-11-17
申请号：US10846062
申请日：2004-05-14
CPC分类号： A61B5/0059 , A61K41/0028 , A61K49/0089
摘要： In accordance with embodiments of the present technique, a combined modality imaging system includes a first imaging device of a first modality and a second imaging device of a second modality that is different from the first modality. The first and the second imaging devices are both adapted to interact with a contrast agent adapted to be received in a subject. The contrast agent includes an deformable particle that has a geometry that varies in response to an emission from the first imaging device. The deformable particle also includes a fluorescent component adapted to emit electromagnetic radiation that is detectable by the second imaging device and a quenching component separated from the fluorescent component at a distance based on the geometry and that which is adapted to absorb a portion of the electromagnetic radiation from the fluorescent component.
摘要翻译： 根据本技术的实施例，组合模态成像系统包括第一模态的第一成像装置和与第一模态不同的第二模态的第二成像装置。 第一和第二成像装置都适于与适于被接收在受试者中的造影剂相互作用。 造影剂包括可变形颗粒，其具有响应于来自第一成像装置的发射而变化的几何形状。 可变形颗粒还包括适于发射可被第二成像装置检测的电磁辐射的荧光组件，以及基于该几何形状在一定距离处从荧光组件分离的淬火组分，以及适于吸收电磁辐射的一部分 从荧光成分。
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公开(公告)号：US20050271585A1
公开(公告)日：2005-12-08
申请号：US10861879
申请日：2004-06-07
申请人： Egidijus Uzgiris , Mohan Amaratunga
发明人： Egidijus Uzgiris , Mohan Amaratunga
CPC分类号： A61K49/0002 , A61K51/065
摘要： A polymer is conjugated to a plurality of molecules having at least a functionality and further comprises an active agent, such as a diagnostic agent or a therapeutic agent. The diagnostic agent is capable of generating a signal detectable by a medical imaging technique. The conjugated polymer has an extended conformation and provides enhanced contrast of images of diseased tissues or enhanced delivery of therapeutic agents to these tissues.
摘要翻译： 聚合物与至少具有官能团的多个分子缀合，并且还包含活性剂，例如诊断剂或治疗剂。 诊断剂能够产生可由医学成像技术检测的信号。 共轭聚合物具有延伸的构象，并且提供患病组织的图像的增强的对比度或增强了对这些组织的治疗剂的递送。
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公开(公告)号：US20050036947A1
公开(公告)日：2005-02-17
申请号：US10638888
申请日：2003-08-12
申请人： Egidijus Uzgiris , Mohan Amaratunga
发明人： Egidijus Uzgiris , Mohan Amaratunga
CPC分类号： A61K49/085 , A61K49/0056 , A61K49/14 , A61K49/146
摘要： A target-specific image-enhancing agent for medical imaging comprises an extended poly(amino acid), wherein at least 90 percent of the amino acid residues are conjugated to signal-generating moieties attached to signal-controlling moieties via bonds that are cleavable by a physiological substance produced by the target. The image-enhancing agent becomes activated when the bonds is cleaved by the physiological substance. The image-enhancing agent is used in detecting and/or diagnosing a disease that is characterized by an overproduction of the substance.
摘要翻译： 用于医学成像的靶特异性图像增强剂包括延伸的聚（氨基酸），其中至少90％的氨基酸残基通过可以被一个或多个氨基酸可切割的键经由键连接到与信号控制部分连接的信号产生部分上 目标产生的生理物质。 当键被生理物质切割时，图像增强剂变得活化。 图像增强剂用于检测和/或诊断以物质过量产生为特征的疾病。
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