公开(公告)号：US20130183299A1

公开(公告)日：2013-07-18

申请号：US13800575

申请日：2013-03-13

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Daniel John O'Shannessy

IPC: C07K16/28

CPC classification number: G01N33/82 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2800/52 ,  G01N2800/56

Abstract: Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing cancers, such as breast cancer, thyroid cancer, colorectal cancer, endometrial cancer, fallopian tube cancer, ovarian cancer, or lung cancer, using the described antibodies, and antigen-binding fragments thereof. The methods involve determining the amount of folate receptor alpha in a sample derived from a subject and comparing this level with the level of folate receptor alpha in a control sample or reference sample.

Abstract translation: 本文描述的是对叶酸受体α，相关多核苷酸，表达载体和表达所述抗体的细胞特异性的抗体及其抗原结合片段。 还提供了使用所述抗体及其抗原结合片段和相关试剂盒的方法。 本文还提供了使用所述抗体及其抗原结合片段来诊断癌症如乳腺癌，甲状腺癌，结肠直肠癌，子宫内膜癌，输卵管癌，卵巢癌或肺癌的方法。 该方法涉及确定来自受试者的样品中叶酸受体α的量，并将该水平与对照样品或参照样品中叶酸受体α的水平进行比较。

公开(公告)号：US10822410B2

公开(公告)日：2020-11-03

申请号：US15821296

申请日：2017-11-22

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Daniel John O'Shannessy ,  Elizabeth B. Somers

IPC: A61K39/395 ,  C07K16/28 ,  G01N33/82 ,  A61P35/00 ,  G01N33/574

Abstract: Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits to detect folate receptor alpha. Provided herein are also methods for diagnosing folate receptor alpha-expressing cancers using the described antibodies, and antigen-binding fragments thereof. The methods involve determining the amount of folate receptor alpha in a sample derived from a subject and comparing this level with the level of folate receptor alpha in a control sample or reference sample.

公开(公告)号：US09599621B2

公开(公告)日：2017-03-21

申请号：US14451044

申请日：2014-08-04

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Daniel John O'Shannessy

IPC: G01N33/574 ,  C07K16/28 ,  G01N33/82

CPC classification number: G01N33/82 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2800/52 ,  G01N2800/56

Abstract: Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing cancers, such as breast cancer, thyroid cancer, colorectal cancer, endometrial cancer, fallopian tube cancer, ovarian cancer, or lung cancer, using the described antibodies, and antigen-binding fragments thereof. The methods involve determining the amount of folate receptor alpha in a sample derived from a subject and comparing this level with the level of folate receptor alpha in a control sample or reference sample.

公开(公告)号：US08834877B2

公开(公告)日：2014-09-16

申请号：US13800575

申请日：2013-03-13

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Daniel John O'Shannessy

IPC: C07K16/28 ,  G01N33/574 ,  G01N33/82

CPC classification number: G01N33/82 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2800/52 ,  G01N2800/56

Abstract: Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing cancers, such as breast cancer, thyroid cancer, colorectal cancer, endometrial cancer, fallopian tube cancer, ovarian cancer, or lung cancer, using the described antibodies, and antigen-binding fragments thereof. The methods involve determining the amount of folate receptor alpha in a sample derived from a subject and comparing this level with the level of folate receptor alpha in a control sample or reference sample.

Abstract translation: 本文描述的是对叶酸受体α，相关多核苷酸，表达载体和表达所述抗体的细胞特异性的抗体及其抗原结合片段。 还提供了使用所述抗体及其抗原结合片段和相关试剂盒的方法。 本文还提供了使用所述抗体及其抗原结合片段诊断癌症如乳腺癌，甲状腺癌，结肠直肠癌，子宫内膜癌，输卵管癌，卵巢癌或肺癌的方法。 该方法涉及确定来自受试者的样品中叶酸受体α的量，并将该水平与对照样品或参照样品中叶酸受体α的水平进行比较。

公开(公告)号：US10101343B2

公开(公告)日：2018-10-16

申请号：US15434326

申请日：2017-02-16

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Daniel John O'Shannessy

IPC: G01N33/82 ,  C07K16/28 ,  G01N33/574

Abstract: Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing cancers, such as breast cancer, thyroid cancer, colorectal cancer, endometrial cancer, fallopian tube cancer, ovarian cancer, or lung cancer, using the described antibodies, and antigen-binding fragments thereof. The methods involve determining the amount of folate receptor alpha in a sample derived from a subject and comparing this level with the level of folate receptor alpha in a control sample or reference sample.

公开(公告)号：US10662251B2

公开(公告)日：2020-05-26

申请号：US15684611

申请日：2017-08-23

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Daniel John O'Shannessy

IPC: C07K16/30 ,  G01N33/53 ,  G01N33/68 ,  A61K39/00 ,  G01N33/574 ,  C07K16/28

Abstract: Described herein are antibodies, and antigen-binding fragments thereof, that are specific for tumor endothelial marker 1 (TEM-1), related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing TEM-1-expressing cancers (such as melanoma, sarcoma, bladder cancer or colon cancer) using the described antibodies, and antigen-binding fragments thereof. The methods involve determining the amount of TEM-1 in a biological sample derived from a subject and comparing this level with the level of TEM-1 in a known standard or reference sample.

公开(公告)号：US20170168078A1

公开(公告)日：2017-06-15

申请号：US15434326

申请日：2017-02-16

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Daniel John O'Shannessy

IPC: G01N33/82 ,  C07K16/28

CPC classification number: G01N33/82 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2800/52 ,  G01N2800/56

Abstract: Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing cancers, such as breast cancer, thyroid cancer, colorectal cancer, endometrial cancer, fallopian tube cancer, ovarian cancer, or lung cancer, using the described antibodies, and antigen-binding fragments thereof. The methods involve determining the amount of folate receptor alpha in a sample derived from a subject and comparing this level with the level of folate receptor alpha in a control sample or reference sample.

公开(公告)号：US20140341897A1

公开(公告)日：2014-11-20

申请号：US14451044

申请日：2014-08-04

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Daniel John O'Shannessy

IPC: G01N33/574

CPC classification number: G01N33/82 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2800/52 ,  G01N2800/56

Abstract: Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing cancers, such as breast cancer, thyroid cancer, colorectal cancer, endometrial cancer, fallopian tube cancer, ovarian cancer, or lung cancer, using the described antibodies, and antigen-binding fragments thereof. The methods involve determining the amount of folate receptor alpha in a sample derived from a subject and comparing this level with the level of folate receptor alpha in a control sample or reference sample.

Abstract translation: 本文描述的是对叶酸受体α，相关多核苷酸，表达载体和表达所述抗体的细胞特异性的抗体及其抗原结合片段。 还提供了使用所述抗体及其抗原结合片段和相关试剂盒的方法。 本文还提供了使用所述抗体及其抗原结合片段诊断癌症如乳腺癌，甲状腺癌，结肠直肠癌，子宫内膜癌，输卵管癌，卵巢癌或肺癌的方法。 该方法涉及确定来自受试者的样品中叶酸受体α的量，并将该水平与对照样品或参照样品中叶酸受体α的水平进行比较。