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公开(公告)号：US09527921B2
公开(公告)日：2016-12-27
申请号：US15098869
申请日：2016-04-14
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Yoshimasa Sakamoto , Yusuke Adachi , Junji Matsui , Yu Kato , Yoichi Ozawa , Takanori Abe , Ken Ito , Yuya Nakazawa , Sho Tachino , Katsuhisa Suzuki , Kishan Agarwala , Kana Hoshino , Masahiko Katayama
IPC: A61K39/395 , C07K16/32 , A61K33/24 , A61K31/47 , A61K31/337 , C07K16/28 , C07K16/30 , C07K14/705 , C07K14/71 , A61K39/00
CPC classification number: C07K16/32 , A61K31/337 , A61K31/47 , A61K33/24 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K16/3023 , C07K16/303 , C07K2317/20 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/21 , C07K2319/42 , C12N9/14 , C12Y301/03001 , A61K2300/00
Abstract: The present invention provides an anti-human Notch4 antibody or a Notch4 binding fragment thereof that may have neutralizing activity against human Notch4, as well as a pharmaceutical composition comprising the same as the active ingredient. The present inventors obtained a mouse anti-human Notch4 antibody that has high neutralizing activity and binding affinity towards human Notch4 and determined the complementarity determining region (CDR) sequence of the mouse anti-human Notch4 antibody. This enabled the production of a humanized antibody comprising the variable region of heavy and light chains as well as the CDR sequence of the mouse anti-human Notch4 antibody.
Abstract translation: 本发明提供了可能对人Notch4具有中和活性的抗人Notch4抗体或Notch4结合片段，以及包含与活性成分相同的药物组合物。 本发明人获得了对人Notch4具有高中和活性和结合亲和力的小鼠抗人Notch4抗体，并确定了小鼠抗人Notch4抗体的互补决定区（CDR）序列。 这使得能够生产包含重链和轻链的可变区以及小鼠抗人Notch4抗体的CDR序列的人源化抗体。
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公开(公告)号：US10358485B2
公开(公告)日：2019-07-23
申请号：US16217360
申请日：2018-12-12
Applicant: Eisai R&D Management Co., Ltd. , UCL Business PLC
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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公开(公告)号：US20160347858A1
公开(公告)日：2016-12-01
申请号：US15098869
申请日：2016-04-14
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Yoshimasa Sakamoto , Yusuke Adachi , Junji Matsui , Yu Kato , Yoichi Ozawa , Takanori Abe , Ken Ito , Yuya Nakazawa , Sho Tachino , Katsuhisa Suzuki , Kishan Agarwala , Kana Hoshino
IPC: C07K16/32 , A61K31/337 , A61K31/47 , A61K39/395 , A61K33/24
CPC classification number: C07K16/32 , A61K31/337 , A61K31/47 , A61K33/24 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K16/3023 , C07K16/303 , C07K2317/20 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/21 , C07K2319/42 , C12N9/14 , C12Y301/03001 , A61K2300/00
Abstract: The present invention provides an anti-human Notch4 antibody or a Notch4 binding fragment thereof that may have neutralizing activity against human Notch4, as well as a pharmaceutical composition comprising the same as the active ingredient. The present inventors obtained a mouse anti-human Notch4 antibody that has high neutralizing activity and binding affinity towards human Notch4 and determined the complementarity determining region (CDR) sequence of said mouse anti-human Notch4 antibody. This enabled the production of a humanized antibody comprising the variable region of heavy and light chains as well as the CDR sequence of said mouse anti-human Notch4 antibody.
Abstract translation: 本发明提供了可能对人Notch4具有中和活性的抗人Notch4抗体或Notch4结合片段，以及包含与活性成分相同的药物组合物。 本发明人获得了对人Notch4具有高中和活性和结合亲和力的小鼠抗人Notch4抗体，并确定了所述小鼠抗人Notch4抗体的互补决定区（CDR）序列。 这使得能够产生包含重链和轻链的可变区以及所述小鼠抗人Notch4抗体的CDR序列的人源化抗体。
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公开(公告)号：US11578120B2
公开(公告)日：2023-02-14
申请号：US17030655
申请日：2020-09-24
Applicant: Eisai R&D Management Co., Ltd. , UCL Business LTD
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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公开(公告)号：US20210024622A1
公开(公告)日：2021-01-28
申请号：US17030655
申请日：2020-09-24
Applicant: Eisai R&D Management Co., Ltd. , UCL Business LTD
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US20170096493A1
公开(公告)日：2017-04-06
申请号：US15382821
申请日：2016-12-19
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Yoshimasa Sakamoto , Yusuke Adachi , Junji Matsui , Yu Kato , Yoichi Ozawa , Takanori Abe , Ken Ito , Yuya Nakazawa , Sho Tachino , Katsuhisa Suzuki , Kishan Agarwala , Kana Hoshino , Masahiko Katayama
IPC: C07K16/32 , A61K31/337 , A61K31/47 , A61K39/395 , A61K33/24
CPC classification number: C07K16/32 , A61K31/337 , A61K31/47 , A61K33/24 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K16/3023 , C07K16/303 , C07K2317/20 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/21 , C07K2319/42 , C12N9/14 , C12Y301/03001 , A61K2300/00
Abstract: The present invention provides an anti-human Notch4 antibody or a Notch4 binding fragment thereof that may have neutralizing activity against human Notch4, as well as a pharmaceutical composition comprising the same as the active ingredient. The present inventors obtained a mouse anti-human Notch4 antibody that has high neutralizing activity and binding affinity towards human Notch4 and determined the complementarity determining region (CDR) sequence of said mouse anti-human Notch4 antibody. This enabled the production of a humanized antibody comprising the variable region of heavy and light chains as well as the CDR sequence of said mouse anti-human Notch4 antibody.
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公开(公告)号：US20240034777A1
公开(公告)日：2024-02-01
申请号：US18149905
申请日：2023-01-04
Applicant: Eisai R&D Management Co., Ltd , UCL Business LTD
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
CPC classification number: C07K16/18 , C07K14/4711 , C12N15/85 , A61P25/28 , C12N15/62 , A61K39/3955 , C07K2317/24 , C12N2015/8518 , C07K2317/56 , C07K2317/34 , C07K2317/76 , C07K2317/565
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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公开(公告)号：US10829547B2
公开(公告)日：2020-11-10
申请号：US16161586
申请日：2018-10-16
Applicant: Eisai R&D Management Co., Ltd. , UCL Business LTD
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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公开(公告)号：US20190112365A1
公开(公告)日：2019-04-18
申请号：US16217360
申请日：2018-12-12
Applicant: Eisai R&D Management Co., Ltd. , UCL Business PLC
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
CPC classification number: C07K16/18 , A61K39/3955 , A61K2039/505 , A61P25/28 , C07K14/4711 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/62 , C12N15/85 , C12N2015/8518
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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公开(公告)号：US20190112364A1
公开(公告)日：2019-04-18
申请号：US16161586
申请日：2018-10-16
Applicant: Eisai R&D Management Co., Ltd. , UCL Business PLC
Inventor： Malcolm Ian Roberts , James Martin Staddon , Hettihewage Alfred Rohan De Silva , Jared Spidel , Hirofumi Aoyagi , Shigeru Akasofu , Yutaka Hashizume , Kishan Agarwala
Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
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