公开(公告)号：US20180057499A1

公开(公告)日：2018-03-01

申请号：US15689481

申请日：2017-08-29

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Richard Clark ,  Tetsuya Kawahara ,  Daisuke Iida ,  Shinsuke Hirota ,  Yasuaki Kamada ,  Toshiyuki Ohfusa ,  Naoki Yoneda ,  Fumiyoshi Matsuura ,  So Yasui

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61P17/06 ,  A61P29/00

Abstract: The compounds represented by formulas (I) to (XVIII) or pharmaceutically acceptable salts thereof.

公开(公告)号：US10227349B2

公开(公告)日：2019-03-12

申请号：US15689481

申请日：2017-08-29

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Richard Clark ,  Tetsuya Kawahara ,  Daisuke Iida ,  Shinsuke Hirota ,  Yasuaki Kamada ,  Toshiyuki Ohfusa ,  Naoki Yoneda ,  Fumiyoshi Matsuura ,  So Yasui

IPC: C07D487/04 ,  A61K31/519 ,  A61P17/06 ,  A61P29/00

Abstract: The disclosure provides pyrazolo[1,5-a]pyrimidine compounds, and pharmaceutically acceptable salts thereof, having protease-activated receptor 2 (PAR2) inhibitory action, pharmaceutical compositions containing the same, and methods of treatment using the same.