公开(公告)号：US20250051322A1

公开(公告)日：2025-02-13

申请号：US18722917

申请日：2023-01-12

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Ikuo Kushida ,  Yoko Ito ,  So Yasui ,  Takashi Fukuyama ,  Nobuaki Sato ,  Taro Asaba

IPC: C07D451/02 ,  A61K31/506

Abstract: Crystals of compounds represented by formula (I) having potential as drug substances for pharmaceuticals, as well as salts of compounds represented by formula (I) and their crystals.

公开(公告)号：US20180057499A1

公开(公告)日：2018-03-01

申请号：US15689481

申请日：2017-08-29

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Richard Clark ,  Tetsuya Kawahara ,  Daisuke Iida ,  Shinsuke Hirota ,  Yasuaki Kamada ,  Toshiyuki Ohfusa ,  Naoki Yoneda ,  Fumiyoshi Matsuura ,  So Yasui

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61P17/06 ,  A61P29/00

Abstract: The compounds represented by formulas (I) to (XVIII) or pharmaceutically acceptable salts thereof.

公开(公告)号：US11691990B2

公开(公告)日：2023-07-04

申请号：US17058406

申请日：2019-08-14

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Jun Niijima ,  Hirofumi Kuroda ,  So Yasui ,  Yoko Ito ,  Ikuo Kushida

IPC: C07D519/00 ,  A61P35/00 ,  C07F9/6587 ,  C07H21/00 ,  A61K31/7084

CPC classification number: C07D519/00 ,  C07B2200/13

Abstract: The present invention provides crystals of (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-Difluoro-34,39-bis(sulfanyl)-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34λ5,39λ5-diphosphaoctacyclo[28.6.4.13,36.128,31.04,8.07,12.019,24.023,27]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene-34,39-dione (Compound (I)) ammonium salts, Compound (I) sodium salts, or Compound (I), possessing a potential to be used as drug substance in pharmaceuticals.

公开(公告)号：US10227349B2

公开(公告)日：2019-03-12

申请号：US15689481

申请日：2017-08-29

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Richard Clark ,  Tetsuya Kawahara ,  Daisuke Iida ,  Shinsuke Hirota ,  Yasuaki Kamada ,  Toshiyuki Ohfusa ,  Naoki Yoneda ,  Fumiyoshi Matsuura ,  So Yasui

IPC: C07D487/04 ,  A61K31/519 ,  A61P17/06 ,  A61P29/00

Abstract: The disclosure provides pyrazolo[1,5-a]pyrimidine compounds, and pharmaceutically acceptable salts thereof, having protease-activated receptor 2 (PAR2) inhibitory action, pharmaceutical compositions containing the same, and methods of treatment using the same.