公开(公告)号：US08440685B1

公开(公告)日：2013-05-14

申请号：US12657052

申请日：2010-01-12

申请人： Elaine A. DeLack

发明人： Elaine A. DeLack

IPC分类号： A01N43/42 ,  A01N43/38 ,  A61K31/44 ,  A61K31/40 ,  C07D498/00 ,  C07D513/00 ,  C07D515/00

CPC分类号： A61K31/475 ,  A61K9/0014 ,  A61K9/7015 ,  A61K31/40 ,  A61K31/44 ,  A61K31/522 ,  C07D471/14 ,  A61K2300/00

摘要： A method for treatment of the symptoms of neurologic dysfunctions, including major depression, an autism spectrum disorder (ASD), and schizophrenia. The patient is administered an amount of a compound that increases the catalytic activity of MAO-A. The effective compound is preferably reserpine, administered in a dosage of less than about 0.03 mg per day. The reserpine may be administered topically or transdermally at a dosage in the range from about 0.002 mg per day to about 0.02 mg per day.

摘要翻译： 一种治疗神经功能障碍症状的方法，包括重度抑郁症，自闭症谱系障碍（ASD）和精神分裂症。 给予患者一定量的增加MAO-A的催化活性的化合物。 有效化合物优选为利血平，以小于约0.03mg /天的剂量施用。 利血平可以局部或透皮给药，剂量范围为每天约0.002mg至约0.02mg。

公开(公告)号：US08314136B1

公开(公告)日：2012-11-20

申请号：US12660257

申请日：2010-02-23

申请人： Elaine A. DeLack

发明人： Elaine A. DeLack

IPC分类号： A01N43/50 ,  A61K31/415

CPC分类号： A61K31/4164 ,  A61K9/0014

摘要： A method for treating Alzheimer's Disease (AD) or Autism Spectrum Disorder (ASD) by administering at least one alky ester of imidazolecarboxylc acid, preferably methyl 4-imidazolecarboxylate. It is hypothesized that the treatment counters AD/ASD by maintaining the intracellular/extracellular osmolyte gradient in the central nervous system (CNS) within a substantially normal range. The methyl 4-imidazolecarboxylate may be administered orally, by inhaler, by injection or by transdermal application. When administered by transdermal application, the dosage range may be from about 0.01 mcg per day to about 3.0 mcg per day, preferably from about 0.1 mcg per day to about 0.3 mcg per day.

摘要翻译： 通过施用至少一种咪唑半羧酸的烷基酯，优选4-咪唑羧酸甲酯来治疗阿尔茨海默病（AD）或自闭症谱系障碍（ASD）的方法。 假设通过将中枢神经系统（CNS）中的细胞内/细胞外渗透液梯度维持在基本正常范围内来治疗AD / ASD。 4-咪唑羧酸甲酯可通过口服，吸入剂，注射剂或透皮给药口服。 当通过透皮施用施用时，剂量范围可以是每天约0.01mcg至约3.0mcg /天，优选约0.1mcg /天至约0.3mcg /天。