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公开(公告)号：US09205132B2
公开(公告)日：2015-12-08
申请号：US13784963
申请日：2013-03-05
CPC分类号： A61K38/2221 , C07K14/64 , A61K2300/00
摘要： The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
摘要翻译： 本公开涉及通过急性干预减少代偿失调的方法，包括患有急性失代偿性心力衰竭的受试者。 特别地，本公开提供了通过施用药学有效量的松弛素治疗急性心脏代偿失调的方法。
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公开(公告)号：US09579363B2
公开(公告)日：2017-02-28
申请号：US14723701
申请日：2015-05-28
CPC分类号： A61K38/2221 , C07K14/64 , A61K2300/00
摘要： The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
摘要翻译： 本公开涉及通过急性干预减少代偿失调的方法，包括患有急性失代偿性心力衰竭的受试者。 特别地，本公开提供了通过施用药学有效量的松弛素治疗急性心脏代偿失调的方法。
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公开(公告)号：US20170151311A1
公开(公告)日：2017-06-01
申请号：US15412447
申请日：2017-01-23
IPC分类号： A61K38/22
CPC分类号： A61K38/2221 , C07K14/64 , A61K2300/00
摘要： The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
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公开(公告)号：US20150320834A1
公开(公告)日：2015-11-12
申请号：US14723701
申请日：2015-05-28
IPC分类号： A61K38/22
CPC分类号： A61K38/2221 , C07K14/64 , A61K2300/00
摘要： The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
摘要翻译： 本公开涉及通过急性干预减少代偿失调的方法，包括患有急性失代偿性心力衰竭的受试者。 特别地，本公开提供了通过施用药学有效量的松弛素治疗急性心脏代偿失调的方法。
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公开(公告)号：US20130210730A1
公开(公告)日：2013-08-15
申请号：US13784963
申请日：2013-03-05
IPC分类号： A61K38/22
CPC分类号： A61K38/2221 , C07K14/64 , A61K2300/00
摘要： The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
摘要翻译： 本公开涉及通过急性干预减少代偿失调的方法，包括患有急性失代偿性心力衰竭的受试者。 特别地，本公开提供了通过施用药学有效量的松弛素治疗急性心脏代偿失调的方法。
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公开(公告)号：US20060052304A1
公开(公告)日：2006-03-09
申请号：US11191824
申请日：2005-07-27
申请人： Dennis Stewart
发明人： Dennis Stewart
CPC分类号： A61K38/1709 , A61K38/2221
摘要： The invention relates to the discovery that relaxin receptors exist in bone and related sutures. As such, bone can be remodeled, repaired, removed or grown. Particularly, the invention pertains to a method for modifying a target bone by administering a relaxin compound which binds to relaxin receptors and by monitoring a change in the target bone. The invention further encompasses methods of modifying the height of a human subject.
摘要翻译： 本发明涉及松弛素受体存在于骨骼和相关缝线中的发现。 因此，骨可以被改造，修复，去除或生长。 特别地，本发明涉及通过施用结合松弛素受体的松弛素化合物和通过监测靶骨的变化来修饰靶骨的方法。 本发明还包括改变人类受试者的身高的方法。
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公开(公告)号：US20050186526A1
公开(公告)日：2005-08-25
申请号：US11015093
申请日：2004-12-16
IPC分类号： A61C7/00 , A61C7/08 , A61C7/12 , A61C19/06 , A61K31/19 , A61K31/485 , A61K31/56 , A61K38/18 , A61K38/19 , A61K38/22 , A61K38/48 , A61K45/06 , A61C3/00
CPC分类号： A61C7/00 , A61C7/08 , A61C7/12 , A61C19/063 , A61K31/19 , A61K31/485 , A61K31/56 , A61K38/1825 , A61K38/1866 , A61K38/2221 , A61K38/4886 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods for accelerating orthodontic tooth movement and for treating relapse. The orthodontic methods comprise applying force to reposition teeth and administering a tissue remodeling and/or an angiogenic substance to the periodontal tissue surrounding the teeth to be moved. The substance may be delivered before, during, or after the teeth are moved, and the substance may be selectively applied only to those teeth undergoing movement at any particular time. The substance may be applied from the dental repositioning appliance or may be applied separately, either locally or systemically. Orthodontic kits are also encompassed by the instant invention.
摘要翻译： 本发明提供加速正畸牙齿运动和治疗复发的方法。 正畸方法包括施加力以重新定位牙齿并且向围绕要移动的牙齿周围的牙周组织施用组织重塑和/或血管生成物质。 该物质可以在牙齿移动之前，期间或之后递送，并且物质可以选择性地仅施加到在任何特定时间经历运动的那些牙齿。 物质可以从牙齿重新定位装置施用，或者可以局部地或全身地分开施用。 本发明也包括正畸试剂盒。
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公开(公告)号：US06508448B1
公开(公告)日：2003-01-21
申请号：US09802566
申请日：2001-03-09
申请人： Dennis Stewart
发明人： Dennis Stewart
IPC分类号： E04G2508
CPC分类号： E04F21/18 , E04F21/1805
摘要： An adjustable drywall support apparatus for holding a gypsum wallboard in place as it is being installed at ceiling level. The adjustable drywall support apparatus includes a support assembly including an elongate tubular member and a shaft member being telescopingly disposed in the elongate tubular member; and also includes a cross member assembly including a tubular main cross member being securely attached to the support assembly and being adapted to engage and support a drywall.
摘要翻译： 一种可调节的墙壁支撑装置，用于在石膏墙板安装在天花板高度时将石膏墙板保持在适当的位置。 可调节的墙壁支撑装置包括支撑组件，其包括细长管状构件和可伸缩地设置在细长管状构件中的轴构件; 并且还包括横向构件组件，其包括牢固地附接到支撑组件并且适于接合和支撑干式墙壁的管状主横梁。
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公开(公告)号：US08574851B2
公开(公告)日：2013-11-05
申请号：US13129597
申请日：2009-11-24
CPC分类号： G01N33/689 , G01N2800/368 , G01N2800/50
摘要： The present disclosure relates to methods for detecting an increased risk of preeclampsia, determining the presence of preeclampsia, reducing the likelihood that preeclampsia will develop and treating preeclampsia. It also provides methods of measuring relaxin levels in a biological sample of a pregnant woman.
摘要翻译： 本公开涉及用于检测先兆子痫风险增加的方法，确定先兆子痫的存在，减少先兆子痫发展和治疗先兆子痫的可能性。 它还提供了测量孕妇生物样品中松弛素水平的方法。
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公开(公告)号：US20110281801A1
公开(公告)日：2011-11-17
申请号：US13129597
申请日：2009-11-24
IPC分类号： A61K38/22 , C07K16/26 , A61P9/12 , A61P43/00 , A61P13/12 , A61P9/00 , G01N33/566 , A61P15/00
CPC分类号： G01N33/689 , G01N2800/368 , G01N2800/50
摘要： The present disclosure relates to methods for detecting an increased risk of preeclampsia, determining the presence of preeclampsia, reducing the likelihood that preeclampsia will develop and treating preeclampsia. It also provides methods of measuring relaxin levels in a biological sample of a pregnant woman.
摘要翻译： 本公开涉及用于检测先兆子痫风险增加的方法，确定先兆子痫的存在，减少先兆子痫发展和治疗先兆子痫的可能性。 它还提供了测量孕妇生物样品中松弛素水平的方法。
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