公开(公告)号：US20140121531A1

公开(公告)日：2014-05-01

申请号：US13829794

申请日：2013-03-14

Applicant: Electronics and Telecommunications Research Institute

Inventor： Kibong SONG ,  Yong Ju YUN ,  Kwan Su KIM ,  Yo Han CHOI

IPC: A61B5/16 ,  G01B9/02

CPC classification number: A61B5/0066 ,  A61B5/4011 ,  A61B5/4088

Abstract: Provided are apparatus and method for diagnosing Alzheimer's disease. The diagnosis apparatus may include a rod type image probe obtaining signals on a state of an olfactory epithelium tissue region, the rod type image probe including an end portion configured to be inserted into a nose and be in contact with the olfactory epithelium tissue region, a delivering element, by which the signals may be transmitted from the olfactory epithelium tissue region, the delivering element being connected to other end portion of the rod type image probe, and a signal processing unit converting the signals transmitted from the delivering element into digital signals.

Abstract translation: 提供用于诊断阿尔茨海默氏病的装置和方法。 诊断装置可以包括获取嗅觉上皮组织区域的状态的信号的杆型图像探针，所述杆型图像探针包括构造成插入到鼻中并与嗅觉上皮细胞组织区域接触的端部， 传送元件，通过该元件可以从嗅觉上皮组织区域传输信号，传送元件连接到杆式图像探测器的另一端部，以及信号处理单元，将从传送元件传输的信号转换为数字信号。

公开(公告)号：US20140057364A1

公开(公告)日：2014-02-27

申请号：US13801925

申请日：2013-03-13

Applicant: Electronics and Telecommunications Research Institute

Inventor： Chang-Beom KIM ,  Kibong SONG ,  Kwan Su KIM

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N33/54326 ,  G01N33/582 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: Provided is a method of diagnosing Alzheimer's disease. The method of diagnosing Alzheimer's disease includes preparing magnetic particles having primary capture antibodies specifically bonded with beta-amyloid adsorbed thereon, introducing saliva containing beta-amyloid into the magnetic particles to bond the beta-amyloid contained in the saliva with the primary capture antibodies, bonding secondary capture antibodies labeled with fluorescent substances to the magnetic particles bonded with the beta-amyloid to form a complex, disposing the complex in a channel region of an photoelectric conversion device in which photoelectric current is changed according to an amount of incident light, and measuring photoelectric current changed by light excited from the complex to quantify a concentration of the beta-amyloid contained in the saliva.

Abstract translation: 提供了一种诊断阿尔茨海默病的方法。 诊断阿尔茨海默病的方法包括制备具有与其上吸附的β-淀粉样蛋白特异性结合的初级捕获抗体的磁性颗粒，将含有β-淀粉样蛋白的唾液引入磁性颗粒中以将含有唾液中的β-淀粉样蛋白与初级捕获抗体结合，键合 用荧光物质标记的二次捕获抗体与β-淀粉样蛋白结合的磁性颗粒形成复合物，将该复合物置于光电转换装置的通道区域中，其中光电流根据入射光量而改变，并测量 由络合物激发光的光电流变化，以量化唾液中所含β-淀粉样蛋白的浓度。

公开(公告)号：US20130337466A1

公开(公告)日：2013-12-19

申请号：US13843574

申请日：2013-03-15

Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE

Inventor： Chang-Beom KIM ,  Kibong SONG ,  Kwan Su KIM

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N33/54326 ,  G01N33/54373

Abstract: Provided is a method for diagnosing Alzheimer/s disease using a decomposed biomaterial. The method includes: preparing magnetic particles on which primary capture antibodies specifically bound to beta-amyloid are adsorbed; decomposing a biomaterial including beta-amyloid; binding the beta-amyloid to the primary capture antibodies; binding secondary capture antibodies labeled with a fluorescent material to the magnetic particles bound to the beta-amyloid to form a complex; disposing the complex in a channel region of a photo field effect transistor in which a photocurrent is changed according to the amount of incident light; and measuring the photocurrent changed by light excited from the complex to quantify the concentration of the beta-amyloid existing in the biomaterial.

Abstract translation: 提供了使用分解生物材料诊断阿尔茨海默病的方法。 该方法包括：制备其上吸附了特异性结合β-淀粉样蛋白的初级捕获抗体的磁性颗粒; 分解包括β-淀粉样蛋白在内的生物材料; 将β-淀粉样蛋白与初级捕获抗体结合; 用荧光材料标记的结合二次捕获抗体结合到β-淀粉样蛋白上形成复合物的磁性颗粒; 将复合物设置在光电流根据入射光量变化的光电场效应晶体管的沟道区域中; 并测量由络合物激发的光改变的光电流，以量化存在于生物材料中的β-淀粉样蛋白的浓度。