公开(公告)号：US20230392144A1

公开(公告)日：2023-12-07

申请号：US18328650

申请日：2023-06-02

Applicant: Element Biosciences, Inc.

Inventor： Andrew PRICE ,  Junhua ZHAO ,  Semyon KRUGLYAK ,  Kelly BLEASE ,  Hua YU ,  Andrew ALTOMARE ,  Ryan KELLEY ,  Juan MORENO

IPC: C12N15/10 ,  C12Q1/6834

CPC classification number: C12N15/1093 ,  C12Q1/6834

Abstract: The present disclosure provides compositions comprising reagents employed in a nucleic acid library preparation workflow for removing deaminated bases, and methods for using the reagents. The compositions and methods described herein reduce base call errors, such as C:G to T:A transitions, in nucleic acid sequencing workflows.