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公开(公告)号：US20090054457A1
公开(公告)日：2009-02-26
申请号：US12259085
申请日：2008-10-27
IPC分类号： A61K31/496 , C07D417/02 , A61K31/454 , A61P3/10 , A61P21/00 , A61P9/00
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US20050197346A1
公开(公告)日：2005-09-08
申请号：US11015915
申请日：2004-12-17
IPC分类号： A61K31/496 , C07D211/58 , C07D277/64 , C07D417/02 , C07D417/12
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US20060229317A1
公开(公告)日：2006-10-12
申请号：US11452479
申请日：2006-06-13
IPC分类号： A61K31/496 , C07D417/14 , C07D413/14
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
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公开(公告)号：US07262198B2
公开(公告)日：2007-08-28
申请号：US11452479
申请日：2006-06-13
申请人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Kenneth Rehder , Jeff Zablocki
发明人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Kenneth Rehder , Jeff Zablocki
IPC分类号： A61K31/496 , C07D277/64
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US07115610B2
公开(公告)日：2006-10-03
申请号：US11015915
申请日：2004-12-17
IPC分类号： A61K31/496 , C07D417/12
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US07452889B2
公开(公告)日：2008-11-18
申请号：US11845720
申请日：2007-08-27
申请人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Kenneth Rehder , Jeff Zablocki
发明人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Kenneth Rehder , Jeff Zablocki
IPC分类号： A61K31/496 , C07D417/12
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US20080032993A1
公开(公告)日：2008-02-07
申请号：US11845720
申请日：2007-08-27
IPC分类号： A61K31/496 , A61K31/4468 , A61P3/10 , A61P9/00 , C07D277/64 , C07D409/14
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US20110130362A1
公开(公告)日：2011-06-02
申请号：US13016425
申请日：2011-01-28
申请人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
发明人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
IPC分类号： A61K31/522 , A61K31/695 , A61P11/06 , A61P3/10 , A61P35/04 , A61P1/00 , A61P25/00 , A61P25/28 , A61P25/16
CPC分类号： C07D473/06 , A61K31/522 , C07D473/04
摘要： Disclosed are novel compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.
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公开(公告)号：US07939509B2
公开(公告)日：2011-05-10
申请号：US12724255
申请日：2010-03-15
申请人： Arvinder Dhalla , Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Vaibhav Varkhedkar , Jeff Zablocki
发明人： Arvinder Dhalla , Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Vaibhav Varkhedkar , Jeff Zablocki
CPC分类号： A61K31/52 , A61K31/7076
摘要： Disclosed are novel compounds a compound of Formula I that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular dyslipidemia, diabetes, decreased insulin sensitivity, Polycystic Ovarian Syndrome, Stein-Leventhal syndrome, and obesity.
摘要翻译： 公开了作为部分和全部A1腺苷受体激动剂的新颖化合物，其可用于治疗各种疾病状态，特别是血脂异常，糖尿病，胰岛素敏感性降低，多囊卵巢综合征，Stein-Leventhal综合征和肥胖症。
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公开(公告)号：US20100222300A1
公开(公告)日：2010-09-02
申请号：US12776642
申请日：2010-05-10
申请人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
发明人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
IPC分类号： A61K31/695 , A61P35/00 , A61P3/10 , A61P11/06 , A61P9/00 , A61P1/12 , A61P25/00 , A61P25/28 , A61P25/16 , A61K31/52 , A61K31/522
CPC分类号： C07D473/06 , A61K31/522 , C07D473/04
摘要： Disclosed are novel compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.
摘要翻译： 公开了作为A2B腺苷受体拮抗剂的新型化合物，其可用于治疗各种疾病状态，包括哮喘和腹泻。
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