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公开(公告)号：US07115610B2
公开(公告)日：2006-10-03
申请号：US11015915
申请日：2004-12-17
IPC分类号： A61K31/496 , C07D417/12
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US20080032993A1
公开(公告)日：2008-02-07
申请号：US11845720
申请日：2007-08-27
IPC分类号： A61K31/496 , A61K31/4468 , A61P3/10 , A61P9/00 , C07D277/64 , C07D409/14
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US07452889B2
公开(公告)日：2008-11-18
申请号：US11845720
申请日：2007-08-27
申请人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Kenneth Rehder , Jeff Zablocki
发明人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Kenneth Rehder , Jeff Zablocki
IPC分类号： A61K31/496 , C07D417/12
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US07262198B2
公开(公告)日：2007-08-28
申请号：US11452479
申请日：2006-06-13
申请人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Kenneth Rehder , Jeff Zablocki
发明人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Kenneth Rehder , Jeff Zablocki
IPC分类号： A61K31/496 , C07D277/64
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US20090054457A1
公开(公告)日：2009-02-26
申请号：US12259085
申请日：2008-10-27
IPC分类号： A61K31/496 , C07D417/02 , A61K31/454 , A61P3/10 , A61P21/00 , A61P9/00
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US20050197346A1
公开(公告)日：2005-09-08
申请号：US11015915
申请日：2004-12-17
IPC分类号： A61K31/496 , C07D211/58 , C07D277/64 , C07D417/02 , C07D417/12
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
摘要翻译： 公开了具有式I结构的新型取代的杂环衍生物：该化合物可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变异）心绞痛，稳定和不稳定型心绞痛， 运动诱发心绞痛，充血性心脏病，糖尿病和心肌梗死。
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公开(公告)号：US20060229317A1
公开(公告)日：2006-10-12
申请号：US11452479
申请日：2006-06-13
IPC分类号： A61K31/496 , C07D417/14 , C07D413/14
CPC分类号： C07D211/58 , C07D277/64 , C07D417/12
摘要： Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
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公开(公告)号：US07655638B2
公开(公告)日：2010-02-02
申请号：US11600523
申请日：2006-11-15
CPC分类号： A61K31/7076 , C07D473/16 , C07H19/16
摘要： Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction.
摘要翻译： 公开了作为部分和全部A1腺苷受体激动剂的新型化合物，其可用于治疗各种疾病状态，特别是心动过速和心房扑动，心绞痛和心肌梗死。
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公开(公告)号：US07304070B2
公开(公告)日：2007-12-04
申请号：US10942582
申请日：2004-09-16
申请人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
发明人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
IPC分类号： C07D473/06 , A61K31/522 , A61P25/28 , A61P11/06 , A61P25/16
CPC分类号： C07D473/00 , C07D473/06 , C07D473/08
摘要： Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, cardiovascular diseases, neurological disorders, and diseases related to undesirable angiogenesis.
摘要翻译： 公开了具有式I或式II结构的新型A 2 B 2 N腺苷受体拮抗剂：
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公开(公告)号：US07026321B2
公开(公告)日：2006-04-11
申请号：US10759555
申请日：2004-01-16
申请人： Robert Jiang , Tim Marquart , Jeff Zablocki , Elfatih Elzein , Venkata Palle , Prabha Ibrahim
发明人： Robert Jiang , Tim Marquart , Jeff Zablocki , Elfatih Elzein , Venkata Palle , Prabha Ibrahim
IPC分类号： A61K31/44
CPC分类号： C07D417/12 , C07D277/64
摘要： Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
摘要翻译： 公开了可用于治疗各种疾病状态，特别是心血管疾病如心房和室性心律失常，间歇性跛行，Prinzmetal（变体）心绞痛，稳定和不稳定型心绞痛，运动诱发的心绞痛，充血性心脏病和心肌的新型杂环衍生物 梗死。 该化合物也可用于治疗糖尿病。
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