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公开(公告)号:US20140255406A1
公开(公告)日:2014-09-11
申请号:US14195885
申请日:2014-03-04
发明人: Barrett Allan , Andrew Lawrence Glasebrook , Jirong Lu , Ying Tang , Derrick Ryan Witcher , Donmienne Doen Mun Leung , Pia Pauliina Yachi , Andrew Charles Vendel
IPC分类号: C07K16/24
CPC分类号: C07K16/244 , A61K2039/505 , C07K16/241 , C07K2317/31 , C07K2317/622 , C07K2317/76
摘要: Bispecific antibodies are provided that specifically bind both Tumor Necrosis Factor alpha (TNFα) and Interleukin-17 (IL-17). The bispecific antibodies of the invention are useful for treating various autoimmune diseases, including Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), and Ankylosing Spondylitis (AS).
摘要翻译: 提供特异性结合肿瘤坏死因子α(TNFα)和白细胞介素-17(IL-17)的双特异性抗体。 本发明的双特异性抗体可用于治疗各种自身免疫疾病,包括类风湿关节炎(RA),银屑病关节炎(PsA)和强直性脊柱炎(AS)。
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公开(公告)号:US09416182B2
公开(公告)日:2016-08-16
申请号:US14195885
申请日:2014-03-04
发明人: Barrett Allan , Andrew Lawrence Glasebrook , Jirong Lu , Ying Tang , Derrick Ryan Witcher , Donmienne Doen Mun Leung , Pia Pauliina Yachi , Andrew Charles Vendel
CPC分类号: C07K16/244 , A61K2039/505 , C07K16/241 , C07K2317/31 , C07K2317/622 , C07K2317/76
摘要: Bispecific antibodies are provided that specifically bind both Tumor Necrosis Factor alpha (TNFα) and Interleukin-17 (IL-17). The bispecific antibodies of the invention are useful for treating various autoimmune diseases, including Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), and Ankylosing Spondylitis (AS).
摘要翻译: 提供特异性结合肿瘤坏死因子α(TNFα)和白细胞介素-17(IL-17)的双特异性抗体。 本发明的双特异性抗体可用于治疗各种自身免疫疾病,包括类风湿关节炎(RA),银屑病关节炎(PsA)和强直性脊柱炎(AS)。
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