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1.发明授权Recombinant &agr;-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof 有权重组α-L-艾杜糖醛酸酶，其制备和纯化方法以及用于治疗由其缺陷引起的疾病的方法公开(公告)号：US06426208B1
公开(公告)日：2002-07-30
申请号：US09439923
申请日：1999-11-12
申请人： Emil D. Kakkis , Becky Tanamachi
发明人： Emil D. Kakkis , Becky Tanamachi
IPC分类号： C12N900
CPC分类号： C12N9/88 , A61K38/47 , A61K48/00 , C12N9/2402 , C12Y302/01014 , C12Y302/01075 , C12Y302/01076 , C12Y402/02004
摘要： The present invention provides a recombinant &agr;-L-iduronidase and biologically active fragments and mutants thereof, methods to produce and purify this enzyme as well as methods to treat certain genetic disorders including- &agr;-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).
摘要翻译： 本发明提供了一种重组α-L-艾杜糖醛酸酶及其生物活性片段和突变体，产生和纯化该酶的方法以及治疗某些遗传病症包括-α-L-艾杜糖醛酸酶缺乏和粘多糖贮积症I（MPS 1）的方法， 。
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公开(公告)号：US07041487B2
公开(公告)日：2006-05-09
申请号：US10206443
申请日：2002-07-25
申请人： Emil D. Kakkis , Becky Tanamachi
发明人： Emil D. Kakkis , Becky Tanamachi
CPC分类号： C12N9/88 , A61K38/47 , A61K48/00 , C12N9/2402 , C12Y302/01014 , C12Y302/01075 , C12Y302/01076 , C12Y402/02004
摘要： The present invention provides a recombinant α-L-iduronidase and biologically active fragments and mutants thereof, methods to produce and purify this enzyme as well as methods to treat certain genetic disorders including-α-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).
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公开(公告)号：US20060286087A1
公开(公告)日：2006-12-21
申请号：US11429422
申请日：2006-05-05
申请人： Emil Kakkis , Becky Tanamachi
发明人： Emil Kakkis , Becky Tanamachi
CPC分类号： C12N9/88 , A61K38/47 , A61K48/00 , C12N9/2402 , C12Y302/01014 , C12Y302/01075 , C12Y302/01076 , C12Y402/02004
摘要： The present invention provides a recombinant α-L-iduronidase and biologically active fragments and mutants thereof, methods to produce and purify this enzyme as well as methods to treat certain genetic disorders including—α-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).
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