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91 条记录 (耗时 0.026 秒)

    Package and method for producing the same
    1.
    发明授权
    Package and method for producing the same 有权

    公开(公告)号：US12090228B2

    公开(公告)日：2024-09-17

    申请号：US16975252

    申请日：2019-02-27

    申请人： SEIKAGAKU CORPORATION

    发明人： Mine Higuchi

    IPC分类号： A61K9/19 ,  A61K38/51

    CPC分类号： A61K9/19 ,  A61K38/51 ,  C12Y402/02004

    摘要： There is provided a package wherein a pharmaceutical composition containing a saccharide-degrading enzyme is contained in a container, whereby reduction in titer caused by a low amount of enzyme is suppressed. A package comprising a pharmaceutical composition and a container, wherein the pharmaceutical composition is a lyophilized preparation containing a saccharide-degrading enzyme as an active ingredient, and the container contains the pharmaceutical composition, the inner surface of the container comprising at least one material selected from the group consisting of fine ceramics, silicone resins and fluorine resins.

    Pharmaceutical composition, package and method for producing the same
    2.
    发明授权
    Pharmaceutical composition, package and method for producing the same 有权

    公开(公告)号：US11648299B2

    公开(公告)日：2023-05-16

    申请号：US16975546

    申请日：2019-02-27

    申请人： SEIKAGAKU CORPORATION

    发明人： Mine Higuchi

    IPC分类号： A61K38/51 ,  A61K9/19

    CPC分类号： A61K38/51 ,  A61K9/19 ,  C12Y402/02004

    摘要： There are provided a pharmaceutical composition containing a lyophilized saccharide-degrading enzyme having excellent titer, and a package containing the pharmaceutical composition. The pharmaceutical composition is a unit dose formulation containing a lyophilized saccharide-degrading enzyme with a titer of not less than 0.3 unit/μg as an active ingredient, and containing the saccharide-degrading enzyme in an amount of not less than 2 μg and not more than 8 μg.

    Pharmacological vitreolysis
    5.
    发明授权
    Pharmacological vitreolysis 有权

    公开(公告)号：US08383105B2

    公开(公告)日：2013-02-26

    申请号：US12951787

    申请日：2010-11-22

    申请人： Steve Pakola ,  Marc De Smet

    发明人： Steve Pakola ,  Marc De Smet

    IPC分类号： A61K38/48 ,  A61K38/43 ,  A61M35/00

    CPC分类号： A61K38/484 ,  A61K45/06 ,  C12Y302/01023 ,  C12Y302/01035 ,  C12Y304/21007 ,  C12Y304/24007 ,  C12Y402/02004 ,  C12Y402/02005 ,  C12Y402/02019 ,  A61K2300/00

    摘要： A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD). TPCDs include, but are not limited to, miniplasmin, microplasmin and derivatives and variants thereof. The methods of the invention can be used to reduce the viscosity of the vitreous, liquefy the vitreous, induce posterior vitreous detachment, reduce hemorrhagic blood from the eye, clear or reduce materials toxic to the eye, clear or reduce intraocular foreign substances from the eye, increase diffusion of a composition administered to an eye, reduce extraretinal neovascularization and any combinations thereof. The method can be used in the absence of, or as an adjunct to, vitrectomy.

    Gene encoding chondroitinase ABC and uses therefor
    6.
    再颁专利
    Gene encoding chondroitinase ABC and uses therefor 有权
    基因编码软骨素酶ABC并用于此

    公开(公告)号：USRE43166E1

    公开(公告)日：2012-02-07

    申请号：US12613119

    申请日：2009-11-05

    申请人： Nobuyuki Sato ,  Masahiko Shimada ,  Hiroshi Oda

    发明人： Nobuyuki Sato ,  Masahiko Shimada ,  Hiroshi Oda

    IPC分类号： C12N15/60 ,  C12N15/63 ,  C12N5/10 ,  C12N1/00 ,  C12N1/21 ,  C12N9/88

    CPC分类号： C12Y402/02004 ,  C12N9/88

    摘要： Nucleic acid sequences coding for the chondroitinase ABC gene and isolated chondroitinase ABE protein produced in a host cell transformed with a nucleic acid vector directing the expression of a nucleotide sequence coding for chondroitinase ABE protein described. Chondroitinase ABC prepared by chemical synthesis also described. Monoclonal and polyclonal antibodies which are specifically reactive with chondroitinase ABC protein are disclosed. The isolated chondroitinase ABC can be used in methods of treating intervertebral disc replacement, promoting neurite regeneration, and detecting galactosaminoglycans.

    摘要翻译： 编码软骨素酶ABC基因的核酸序列和分离的软骨素酶ABE蛋白质在用指导编码软骨素酶ABE蛋白质的核苷酸序列的表达的核酸载体转化的宿主细胞中产生。 通过化学合成制备的软骨素酶ABC也有描述。 公开了与软骨素酶ABC蛋白特异性反应的单克隆和多克隆抗体。 分离的软骨素酶ABC可用于治疗椎间盘置换，促进神经突再生和检测半乳糖胺聚糖的方法。