公开(公告)号：US4829079A

公开(公告)日：1989-05-09

申请号：US947270

申请日：1986-12-29

申请人： Emilio Toja ,  Carlo Gorini ,  Carlo Zirotti ,  Fernando Barzaghi ,  Giulio Galliani

发明人： Emilio Toja ,  Carlo Gorini ,  Carlo Zirotti ,  Fernando Barzaghi ,  Giulio Galliani

IPC分类号： C07D333/00 ,  A61K20060101 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61P25/28 ,  C07D207/26 ,  C07D207/273 ,  C07D207/48 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

CPC分类号： C07D401/12 ,  C07D207/48 ,  C07D405/12 ,  C07D409/12

摘要： Memory enhancing 1-(benzenesulfonyl)-2-oxo-5-alkoxy-pyrrolidines are prepared by alkylation of the corresponding pyrrolidones or pyrrolidone precursors.

摘要翻译： 通过相应的吡咯烷酮或吡咯烷酮前体的烷基化制备记忆增强1-（苯磺酰基）-2-氧代-5-烷氧基 - 吡咯烷。

公开(公告)号：US4885307A

公开(公告)日：1989-12-05

申请号：US205958

申请日：1988-06-13

申请人： Emilio Toja ,  Carlo Gorini ,  Fernando Barzaghi ,  Giulio Galliani

发明人： Emilio Toja ,  Carlo Gorini ,  Fernando Barzaghi ,  Giulio Galliani

IPC分类号： A61K31/40 ,  A61P25/18 ,  C07D207/48

CPC分类号： C07D207/48

摘要： Compounds useful in the treatment of patients suffering from intellectual or nervous asthenias, memory failures, senescence or mental strain of the formula (I) ##STR1## in which R' represents hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms, alkenyl containing from 2 to 8 carbon atoms, acyl containing from 1 to 6 carbon atoms or aralkyl containing from 7 to 15 carbon atoms and R represents aryl containing up to 14 carbon atoms, possibly substituted, or a mono- or polycyclic heterocyclic aromatic radical, possibly substituted; also thereapeutic compositions containing those compounds and method of use.

摘要翻译： 用于治疗患有智力或神经失调，记忆障碍，衰老或精神紧张的患者的化合物（I）其中R'表示氢，直链，支链或环状烷基，其含有至多 8个碳原子，含有2至8个碳原子的链烯基，含1至6个碳原子的酰基或含有7至15个碳原子的芳烷基，R表示可含有至多14个碳原子的芳基，或单环或多环 杂环芳族基团，可能被取代; 还含有这些化合物和使用方法的治疗组合物。

公开(公告)号：US4885306A

公开(公告)日：1989-12-05

申请号：US203740

申请日：1988-06-02

申请人： Emilio Toja ,  Carlo Gorini ,  Fernando Barzaghi ,  Giulio Galliani

发明人： Emilio Toja ,  Carlo Gorini ,  Fernando Barzaghi ,  Giulio Galliani

IPC分类号： A61K31/40 ,  A61P25/28 ,  C07D207/48

CPC分类号： C07D207/48

摘要： Compounds useful in the treatment of patients suffering from intellectual or nervous asthenias, memory failures, senescence or mental strain of the formula (I) ##STR1## in which R' and R.sub.2, being identical or different, represent hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms, alkenyl containing from 2 to 8 carbon atoms, acyl containing from 1 to 6 carbon atoms or aralkyl containing from 7 to 15 carbon atoms, R.sub.1 represents a possibly substituted aryl containing up to 14 carbon atoms, or a possibly substituted mono- or polycyclic heterocyclic aromatic radical; also therapeutic compositions containing those compounds and method of use.

摘要翻译： 用于治疗患有智力或神经失调，记忆障碍，衰老或精神紧张的患者（I）的患者的化合物，其中R 1和R 2相同或不同，代表氢，直链，支链或 含有至多8个碳原子的环状烷基，含有2至8个碳原子的烯基，含有1至6个碳原子的酰基或含有7至15个碳原子的芳烷基，R 1表示可能被取代的含有至多14个碳原子的芳基，或 可能取代的单环或多环杂环芳族基团; 还含有这些化合物和使用方法的治疗组合物。

公开(公告)号：US4990531A

公开(公告)日：1991-02-05

申请号：US315170

申请日：1989-02-24

申请人： Giulio Galliani ,  Fernando Barzaghi ,  Michel Fortin ,  Carlo Gorini ,  Emilio Toja

发明人： Giulio Galliani ,  Fernando Barzaghi ,  Michel Fortin ,  Carlo Gorini ,  Emilio Toja

IPC分类号： C07D207/263 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P25/02 ,  C07D207/27 ,  C07D207/48 ,  C07D401/12

CPC分类号： C07D207/48

摘要： Compounds useful for the treatment of patients suffering from muscle spasms of the formula (I) ##STR1## in which R represents the radical ##STR2## in which R.sub.1, in any position on the phenyl nucleus, represents a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or the radical ##STR3## in which R.sub.2 and R.sub.3, identical or different each represents a hydrogen atom, a linear alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or form together with the nitrogen atom to which they are joined, a heterocyclic radical optionally containing another heteroatom, or NO.sub.2, or OR', R' representing hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms, or aryl containing up to 14 carbon atoms, or an SR.sub.4 or S(O)R.sub.5 radical, R.sub.4 and R.sub.5 representing a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or R represents naphthyl, optionally substituted by an R.sub.1 radical, as defined above; also therapeutic compositions containing the same and method of use.

摘要翻译： 可用于治疗患有式（I）的肌肉痉挛的患者的化合物（I）其中R表示基团“IMAGE”，其中在苯基核上任何位置的R 1表示直链，支链或 含有至多8个碳原子的环烷基，烯基或炔基，或其中R 2和R 3相同或不同各自表示氢原子，直链烷基，烯基或炔基，其含有至多8个碳原子的基团， 或与其连接的氮原子一起形成任选地含有另外的杂原子的杂环基团，或代表氢的NO 2或OR'，R'，含有至多8个碳原子的直链，支链或环状烷基，或含有 至多14个碳原子，或SR4或S（O）R5基团，R4和R5代表含有至多8个碳原子的直链，支链或环状烷基，烯基或炔基，或R代表萘基，任选被R1 如上所述; 还含有相同的治疗组合物和使用方法。

公开(公告)号：US5164514A

公开(公告)日：1992-11-17

申请号：US584108

申请日：1990-09-18

申请人： Giulio Galliani ,  Fernando Barzaghi ,  Michel Fortin ,  Carlo Gorini ,  Emilio Toja

发明人： Giulio Galliani ,  Fernando Barzaghi ,  Michel Fortin ,  Carlo Gorini ,  Emilio Toja

IPC分类号： C07D207/48

CPC分类号： C07D207/48

摘要： Compounds useful for the treatment of patients suffering from muscle spasms of the formula (I) ##STR1## in which R represents the radical ##STR2## in which R.sub.1, in any position on the phenyl nucleus, represents a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or the radical ##STR3## in which R.sub.2 and R.sub.3, identical or different each represents a hydrogen atom, a linear alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or form together with the nitrogen atom to which they are joined, a heterocyclic radical optionally containing another heteroatom, or NO.sub.2, or OR', R' representing hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms, or aryl containing up to 14 carbon atoms, or an SR.sub.4 or S(O)R.sub.5 radical, R.sub.4 and R.sub.5 representing a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or R represents naphthyl, optionally substituted by an R.sub.1 radical, as defined above; also therapeutic compositions containing the same and method of use.

摘要翻译： 可用于治疗患有式（I）的肌肉痉挛的患者的化合物（I）其中R表示基团“IMAGE”，其中在苯基核上任何位置的R 1表示直链，支链或 含有至多8个碳原子的环烷基，烯基或炔基，或其中R 2和R 3相同或不同各自表示氢原子，直链烷基，烯基或炔基，其含有至多8个碳原子的基团， 或与其连接的氮原子一起形成任选地含有另外的杂原子的杂环基团，或代表氢的NO 2或OR'，R'，含有至多8个碳原子的直链，支链或环状烷基，或含有 至多14个碳原子，或SR4或S（O）R5基团，R4和R5代表含有至多8个碳原子的直链，支链或环状烷基，烯基或炔基，或R代表萘基，任选被R1 如上所述; 还含有相同的治疗组合物和使用方法。

公开(公告)号：US5081130A

公开(公告)日：1992-01-14

申请号：US584701

申请日：1990-09-19

申请人： Giulio Galliani ,  Fernando Barzaghi ,  Michel Fortin ,  Carlo Gorini ,  Emilio Toja

发明人： Giulio Galliani ,  Fernando Barzaghi ,  Michel Fortin ,  Carlo Gorini ,  Emilio Toja

IPC分类号： C07D207/263 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P25/02 ,  C07D207/27 ,  C07D207/48 ,  C07D401/12

CPC分类号： C07D207/48

摘要： Compounds useful for the treatment of patients suffering from muscle spasms of the formula (I) ##STR1## in which R represents the radical ##STR2## in which R.sub.1, in any position on the phenyl nucleus, represents a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or the radical ##STR3## in which R.sub.2 and R.sub.3, identical or different each represents a hydrogen atom, a linear alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or form together with the nitogen atom to which they are joined, a heterocyclic radical optionally containing another heteroatom, or NO.sub.2, or OR', R' representing hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms, or aryl containing up to 14 carbon atoms, or an SR.sub.4 or S(O)R.sub.5 radical, R.sub.4 and R.sub.5 representing a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or R represents naphthyl, optionally substituted by an R.sub.1 radical, as defined above; also therapeutic compositions containing the same and method of use.

公开(公告)号：US4882350A

公开(公告)日：1989-11-21

申请号：US211288

申请日：1988-06-24

申请人： Emilio Toja ,  Carlo Gorini ,  Fernando Barzaghi ,  Giulio Galliani

发明人： Emilio Toja ,  Carlo Gorini ,  Fernando Barzaghi ,  Giulio Galliani

IPC分类号： C07D411/06 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/42 ,  A61K31/435 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07D207/26 ,  C07D207/273 ,  C07D409/06 ,  C07D413/06

CPC分类号： C07D207/273

摘要： Compounds useful in the treatment of patients suffering from intellectual or nervous asthenias, memory failures, senescence or metal strain of the formula (I) ##STR1## in which R' represents hydrogen, linear, branched or cyclic alkyl containing up to 12 carbon atoms, alkenyl containing from 2 to 8 carbon atoms, acyl containing from 1 to 6 carbon atoms or aralkyl containing from 7 to 15 carbon atoms and R represents aryl containing up to 14 carbon atoms, possibly substituted, or a mono- or polycyclic heterocyclic aromatic radical possibly substituted, provided that if R is unsubstituted phenyl, R' does not represent methyl or ethyl; also therapeutic compositions containing those compounds and method of use.

摘要翻译： 用于治疗患有智力或神经失调，记忆障碍，衰老或金属应变的患者的化合物（I）其中R'表示氢，直链，支链或环状烷基，其含有至多12个 碳原子，含有2至8个碳原子的烯基，含有1至6个碳原子的酰基或含有7至15个碳原子的芳烷基，R代表含有至多14个碳原子的芳基，可能被取代，或单环或多环杂环 芳基可以被取代，条件是如果R是未取代的苯基，则R'不代表甲基或乙基; 还含有这些化合物和使用方法的治疗组合物。