公开(公告)号：US20220273606A1

公开(公告)日：2022-09-01

申请号：US17744369

申请日：2022-05-13

申请人： Emory University

发明人： Jie Song ,  Shuming Nie ,  Craig Hill

IPC分类号： A61K31/28 ,  A61P35/00 ,  A61K33/243 ,  A61K31/282 ,  C07C229/00 ,  B32B21/02 ,  C09D7/65 ,  C09D5/08 ,  C09D5/02

摘要： The disclosure relates polyoxometalate complexes and uses in the management, treatment, or prevention of cancer. In certain embodiments, the polyoxometalate complexes comprise polydentate oxygen bridging ligands such as those of the following formula: [POM{(OCH2)3CX}2], [M6O13{(OCH2)3CX}2], [V6O13{(OCH2)3CX}2], salts, or derivatives thereof wherein POM is a polyoxometalate, M is a metal, and X is defined herein. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising polyoxometalate complexes disclosed herein.

公开(公告)号：US11331297B2

公开(公告)日：2022-05-17

申请号：US16345578

申请日：2017-10-26

申请人： Emory University

发明人： Jie Song ,  Shuming Nie ,  Craig Hill

IPC分类号： A61K31/28 ,  A61P35/00 ,  A61K33/243 ,  A61K31/282 ,  C07C229/00 ,  B32B21/02 ,  C09D7/65 ,  C09D5/08 ,  C09D5/02

摘要： The disclosure relates polyoxometalate complexes and uses in the management, treatment, or prevention of cancer. In certain embodiments, the polyoxometalate complexes comprise polydentate oxygen bridging ligands such as those of the following formula: [POM{(OCH2)3CX}2], [M6O13{(OCH2)3CX}2], [V6O13 {(OCH2)3CX}2], salts, or derivatives thereof wherein POM is a polyoxometalate, M is a metal, and X is defined herein. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising polyoxometalate complexes disclosed herein.

公开(公告)号：US11174352B2

公开(公告)日：2021-11-16

申请号：US16061327

申请日：2016-12-09

申请人： Emory University

发明人： Craig Hill ,  Kevin Sullivan

IPC分类号： C08G83/00 ,  A62D3/35 ,  A62D3/38 ,  A62D101/02 ,  A62D101/26

摘要： This disclosure relates to polymers and polymer compositions having monomer units of polyoxometalates and monomer units comprising hydroxy-terminated molecules such as branched molecules or dendrimers and uses in degradation, decontamination, and deodorization. In certain embodiments, the hydroxy-terminated branched molecules or dendrimers comprise terminal 1,1-tris(hydroxymethyl)methyl or 1,1,1-tris(hydroxyalkyl)methyl groups. In certain embodiments, the hydroxy-terminated molecule is N,N′,N″-tris[tris(hydroxymethyl) methyl]-1,3,5-benzenetricarboxamide.

公开(公告)号：US20190262302A1

公开(公告)日：2019-08-29

申请号：US16345578

申请日：2017-10-26

申请人： Emory University

发明人： Jie Song ,  Shuming Nie ,  Craig Hill

IPC分类号： A61K31/28 ,  A61P35/00 ,  A61K33/243 ,  A61K31/282

摘要： The disclosure relates polyoxometalate complexes and uses in the management, treatment, or prevention of cancer. In certain embodiments, the polyoxometalate complexes comprise polydentate oxygen bridging ligands such as those of the following formula: [POM{(OCH2)3CX}2], [M6O13{(OCH2)3CX}2], [V6O13{(OCH2)3CX}2], salts, or derivatives thereof wherein POM is a polyoxometalate, M is a metal, and X is defined herein. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising polyoxometalate complexes disclosed herein.

公开(公告)号：US20190040208A1

公开(公告)日：2019-02-07

申请号：US16061327

申请日：2016-12-09

申请人： Emory University

发明人： Craig Hill ,  Kevin Sullivan

IPC分类号： C08G83/00 ,  A62D3/35 ,  A62D3/38

摘要： This disclosure relates to polymers and polymer compositions having monomer units of polyoxometalates and monomer units comprising hydroxy-terminated molecules such as branched molecules or dendrimers and uses in degradation, decontamination, and deodorization. In certain embodiments, the hydroxy-terminated branched molecules or dendrimers comprise terminal 1,1-tris(hydroxymethyl)methyl or 1,1,1-tris(hydroxyalkyl)methyl groups. In certain embodiments, the hydroxy-terminated molecule is N,N′,N″-tris[tris(hydroxymethyl) methyl]-1,3,5 -benzenetricarboxamide.